The aim of the study is to development of an algorithm for managing pregnancy and childbirth by studying the functional state of the mother-placenta-fetus system in pregnant women who have undergone COVID-19 in different trimesters of pregnancy.
The object of the study was 105 pregnant women who, were treated at the Samarkand Regional Perinatal Center and a specialized maternity center for pregnant women with COVID-19
Тhe scientific novelty of the research consists of the followings: for the first time in pregnant women infected with COVID-19, a relationship was established between the course of pregnancy, childbirth, the postpartum period and the development of complications depending on the trimester and severity of the disease; a direct correlation has been established between the state of the vessels of the mother-placenta-fetus system (resistance and pulsation indices, Endothelin-1 indicators), disorders in the hemostasis system (D-dimer, platelet aggregation) and the clinical course of the disease in pregnant women who underwent COVID-19; it has been established for the first time that the developed scale for assessing risk factors for non-developing pregnancy in women infected with COVID-19 (age, BMI, obstetric history, gestation period, hemostasis system status, endothelial function and severity of the disease) can serve as a prognostic marker of the degree of risk of pregnancy complications; it was proved for the first time that the choice of effective therapy for restoring hemodynamics in the mother-placenta-fetus system, in women who underwent COVID-19 at different stages of pregnancy, leads to a decrease in the number of thrombophilic complications.
Implementation of the research results. The results of the scientific research were introduced into the practical activities of the Samarkand Regional Perinatal Center by Order No. 128/1 of 01.09.2022 and the Samarkand City Maternity Complex No. 1 by order No. 58/1 of 03.10.2022. In pregnant women who underwent COVID-19 at different periods of pregnancy, changes in the mother-placenta-fetus system were determined using simple and effective research methods, such as ultrasound and Dopplerography, and this saved 53,000 soums; obstetricians and gynecologists, as well as neonatologists and therapists, are needed to diagnose signs of complications in the echocartin, that is, it has been proven that there is no need for other highly qualified specialists for this, due to the lack of need to train new personnel, state budget funds have been saved. With early detection of disorders in the hemostasis system in pregnant women with COVID-19: the period of stay of patients in the hospital was reduced from 10.5 days to 7.5 days and the number of hospital bed days was reduced; due to the reduction of the period of stay in the hospital for several days, the number of necessary drugs was reduced (on average, drugs are used for 1 day in the amount of 130,000 soums). Examination of pregnant women infected with viral diseases using simple and effective research methods such as ultrasound and Dopplerography served to save 85,000 soums: in the early stages up to 16 (10-11 weeks. - fetometry), 19-21, 32-34, 38-40 weeks of pregnancy; due to the absence of the need to use other research methods, it was possible to reduce costs by 23.5%; early detection of changes in the hemostasis system and endothelial dysfunction using fast, budgetary and effective research methods, contributed to the prevention of possible pregnancy complications, as well as the absence of the need to use long-term and expensive research methods, and this saved 106 000 soums: the coagulogram was checked in 105 (100%) patients, time was saved and efficiency was increased; endothelin-1 was also determined in 105 (100%) patients, efficiency was increased by 78.6%.
Improving the functionality of blood circulation in the uteroplacental and fetal-placental systems, a comprehensive analysis of possible complications during pregnancy and childbirth in women who have had viral infections, improving diagnostic, preventive and prognostic measures for managing pregnancy and childbirth contributed to the birth of live, full-term and healthy newborns in women who experienced COVID-19 during pregnancy, as well as a decrease in maternal mortality and perinatal mortality, 43% of women underwent rehabilitation in the postpartum period, 23.8% of women who underwent severe COVID-19 improved their quality of life.
To introduce scientific novelty on the topic “The impact of COVID-19 on the state of hemodynamics in the mother-placenta-fetus system in pregnant women”, a letter was sent to the Ministry of Health from Samarkand State Medical University on November 9, 2022 under No. 4295 (Conclusion of the Ministry of Health No. 8 n-z / 679 of December 15, 2022).
The structure and volume of the dissertation. The content of the dissertation consists of an introduction, five chapters, conclusion, list of used references. The volume of the dissertation consists of 113 pages.
Modernism can be regarded as a movement of thought that has emerged in Europe since the midseventeenth century and influenced the entire world. Modernism, which is based on the idea of enlightenment, has become the opposite of the traditional in every field with the Industrial revolution. Modernism, which affects all areas of society, also causes changes in the field of art and literature. Ottoman society, art and literature were not unfamiliar to this trend, which developed especially under the leadership of European thought and art. After the French Revolution, thoughts affecting the whole world raise Europe as a center. All the world's attention and face turns there. The interest of Ottoman society develops in the same direction. But in the first place, the attention of the Ottoman is for military area. Lost wars and lands, the future of the army, which has lost its former glory and power, is in the West. So the first transformation moves begin on the army. After that, change will begin in other social areas. However, it has been discussed for a long time how these developments and changes will be; in which direction they will affect society and art. The modernization of the Ottoman Empire has taken the road with the dream of capturing the west, reaching that level and living like the west. With the publication of the Tanzimat Fermanı (1839), modernization appears to have exceeded an important threshold. The expression of equality of all citizens in the edict has in some sense been the most modernist breakthrough. Therefore, despite the existence of various changes before it, the proclamation of the Tanzimat edict is considered the beginning of modernism.
Мазкур мақолада рақамли иқтисодиёт тушунчаси, рақамли иқтисодиётга хос бўлган технологик ўзгаришлар, хизмат кўрсатиш соҳасини ривожлантириш бўйича олиб рақамлаштириш соҳасидаги ўзгаришлар
масалалари ёритиб берилган, олиб борилган тадқиқот натижасида муаллифлар томонидан амалий тавсиялар илгари сурилган.
Доказано что в подавляющем большинстве случаев патологические процессы в полости рта особенно при вирусных инфекциях, как правило сопровождаются дисбиотическими изменениями в микрофлоре ротовой жидкости, что в свою очередь приводит к нарушению состояния показателя системы иммунитета. Микрофлора полости рта рассматривается как первичная мишень для любого фактора, который прямо или опосредованно влияет на адгезию и колонизационную резистентность резидентной, транзиторной и добавочной микрофлоры. Проблема лечения заболеваний слизистой оболочки полости рта у детей – это одна из актуальных задач практической стоматологии.
Бутун дунё неврология фидерацияси ҳамжамиятининг маълумотига кўра, дунё бўйича ҳар йили 15 млн. одам инсульт касаллигига мубтало бўлади. Инсульт - бу бош мияда ўткир қон айланишининг бузилиши билан кечадиган нейродегенератив касаллик ҳисобланади. Энергетик етишмовчилик ва лактат-ацидоз ривожланиши натижасида нейродегенератив ўзгаришлар келиб чиқади. Қон оқими хажми пасайган сари ишемия ўчоғида ҳужайра апоптози ва некрози ривожланиб, бу жараён ишемик инфаркт деб аталиб, мия тўқимасининг структур қайтмас жараёни ҳисобланади. Аммо мия тўқимаси коллатерал томирлар орқали қон билан таминланади. Бу жараён инфаркт зонасидаги нейронларга иккиламчи таъсир кўрсатиб, патобиокимёвий каскад хосил қилади. Бу мия тўқимасига цитотоксик ва эксайтотоксик тасир кўрсатади. (Европейская Инициативная Группа по проблеме Инсульта Методические рекомендации Авторы: профессор Вернер Хаке (Гейдельберг, Германия), профессор Маркку Касте (Хельсинки, Финляндия), профессор Джулиен Богусславски (Лозанна, Швейцария), профессор Жан-Марк Оргогозо (Бордо, Франция), профессор Том Скайхой Ольсен (Копенгаген, Дания)).
Ушбу тадқиқотда ўзгаришлар тилости сўлак безининг стимуляция қилинмаган сўлакдаги pH даражасида олдин ва кейин ўрганилган пластмассадан ясалган кисман эчиб олинадиган плиталар протез дастур ЭБ босиб чиқариш ва акрил пластмасса учун қатронлар Протез базаси, Sublingual безнинг стимуляция қилинмаган сўлакдаги pH
қийматларини ўрганиш учун тадқиқот ўтказгандан сўнг, полимер қатронларидан тайёрланган кисман эчиб олинадиган протезли беморларда сўлакнинг pH қиймати статистик ва иссиқ-шифо пластмассадан сезиларли
даражада кам.Флоракс ва тез соддалаштирилган
The article investigated the need for a new approach in the methodology of risks insurance, based on state support inconditions of institutional transformations in agriculture. The article provides advantages and peculiarities of the insurance system in managing agricultural risks. The possibilities of their application in agriculture of the Republic of Uzbekistan were investigated and recommendations were developed.