All articles - Research and experimental medicine
Number of articles: 299
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Evaluation of the effectiveness of physiotherapeutic treatment at the craniocervicalgiaComplication of the pathogenesis of cranioccrvicalgia and clinical polymorphism of the complex of symptoms reveals the need for a systematic approach to restoring healing procedures. The effectiveness of physiotherapy treatment in patients aged 18-35 years with craniocervicalgia was evaluated. Pathogenetic orientation and high efficiency of complex physiotherapeutic treatment were determined.
Doctor's Herald -
First experience of unilateral spinal anesthesia in patients of senior and senior age at operations in the bottom section of the abdominal caveA comparative clinical evaluation of two types of neuraxial blockade: symmetrical unilateral spinal anesthesia and spinal anesthesia during operations on the ground floor of the abdominal cavity in elder-ly patients. After obtaining informed consent were included 30 patients (17 men and 13zhenschin), which are divided into two groups of 15 people, depending on the variant carried out neuraxial blockade. Comparative evaluation of clinical neuraxial blockade was carried out on the basis of the definition of motor and sensory block. Unilateral spinal anesthesia with hyperbaric bupivacaine is an effective method of anesthesia-sided sur-gical interventions on the ground floor of the abdominal cavity and adequate postoperative analgesia positive
Journal problems of biology and medicine -
The complex model of filter for extracorporeal removal systems consists of derived cotton cellulose and polypropylene. This new model of filter has good barrier possibility (binding of the particles of the absorbent) and additional detoxicant properties. This additional characteristics of the complex model of filter (CMF) includes reduction of the level in blood plasma some of toxic substations such as bilirubin - on 22% (p<0,05); the average molecules of the plasma - on 25,4% (p<0,05); the factor of the necrosis to tumors alpha - on 18,5% (p<0,05) from basic level before filtration. There were no reliable changes of the glucose, total protein, albumin, electrolytes concentrations in plasma after filtering through CMF. Premises and basis for realization of the additional detoxification characteristic of the CMF include its biological compatibility and high soiption possibility of derived cellulose. Polypropylene can perfects the barrier properties of CMF. The combination of derived cellulose with polypropylene in complex model of filter -CMF can be offered for the further tests as filter for extracorporeal removal systems. -
Results of study of the causes of nutrition of food in children of 1 year of lifeTo conduct a successful consultation, it is necessary to involve nurses for a pre-medical examination, which will increase the doctor's time for talking with the patient. In turn, the training of nurses attending healthy children at home, nutrition of healthy and sick children, will help improve the knowledge of mothers
Journal problems of biology and medicine -
For the purpose of early diagnosis of sepsis, the index of spontaneous agglomeration of leukocytes and the index of nuclear segmentation of neutrophils were studied in babies. It was found that in young children with sepsis these indices allow differentiating local infection from the septic process, on the one hand, and on the other hand, using the neutrophil nuclear segmentation index and the spontaneous agglomeration index of leukocytes in babies makes it possible to determine the effectiveness treatment and diagnose the progression of the pathological process. -
Results of expremental study on evalution of the mutagenic activity of genetically modified productsThe aim of the study was the evaluation of mutagenic activity of the genetically modified product (soy-bean flour №24) at experiments. As the result, it was found that the dysfunctional to become embryos in fe-males among the experimental groups of rats were 1) the mortality rate of fertilized females of laboratory ani-mals. In group 1 (control male/control female) and group 2 (control male/ experimental female) mortality of fertilized females was about 66.0%, and in in group 3 (experimental male/control female) was about 100%, in the 4 group (experimental male/ experimental female) - 66,7%.
Journal problems of biology and medicine -
Disadvantages and ways of improvement in diagnostics and surgical treatment of the diabetic foot syndromePatients with diabetes mellitus, often, there are changes in the vessels in the form of calcification of the middle shell of arteries and arterioles (arteriolosclerosis of Menkeberg, mediacalcinosis). The determination of the x-ray stage of calcification of the arteries, gives additional information on the state of the vessels of the foot. Destructive changes in blood vessels, soft tissues and bones, conducted surgical interventions are naturally related. The study of these patterns is possible with a timely, critical study of anamnestic, diagnostic data and therapeutic measures. In this regard, to date remain relevant issues related to the development of differentiated treatment, taking into account all possible diagnostic data and improving surgical methods for treating the diabetic foot syndrome.
Doctor's Herald -
Uterine malformations are congenital changes in the female genital organs, from underdevelopment to non—fusion of the Muller ducts with the formation of septa. According to some authors, abnormalities of uterine development occur in 25% of patients with disorders in the reproductive system. -
Comparative characteristics and diagnostic value of the taxonomic characteristics of pathogens of infectious inflammatory diseases of humansThe aim was a comparative study of the variability of some taxonomic characters sown E.coli from sick women urinary tract infections. It was found that E.coli strains isolated from different habitats of the body healthy and sick women with varying frequency detected taxonomic characteristics, which are associated with the adhesiveness of the pathogen. The strains exhibit variability mainly by fermentation of mannitol, sucrose, arabinose, glucose, sodium citrate, hemolytic activity.
Journal problems of biology and medicine -
According to the World Health Organization, there are about 12 million leishmaniasis patients, about 2 million people get this disease every year. An analysis of the situation on skin leishmaniasis, as well as an assessment of the possible impact of climate change on vector carriers, is carried out by mathematical modeling using climate predictors. Modeling the spread of cutaneous leishmaniasis allows to obtain a number of data for possible approximation of the disease in the future. -
Informativity of magnetic-resonance tomography in diagnosis of tuberculosis spondilites and its complications89 magnetic resonance tomograms, which were performed by 72 patients with TS, were analyzed. A spe-cific process was localized in the cervical spine in two patients, in the thoracic and thoracolumbar - in 38, in the lumbar and lumbosacral in 32 patients. Isolated lesions of one or two vertebrae were observed in four cas-es, contact destruction in 48, a combination of contact and isolated destruction at 15. Combination of MRI and X-ray methods broadens the notion of morphological changes in the spine, the stage of the tuberculous process, allows one to study the patterns of development And the dynamics of TC, the effectiveness of conservative and operative treatment
Journal problems of biology and medicine -
The incidence of cutaneous leishmaniasis in the Republic of Uzbekistan in recent years has not tended to decline, and the use of drugs recommended by WHO remains unavailable in the pharmacy network for the public, which leads to the search and use of new alternative therapies. The article presents a new complex method for the treatment of cutaneous leishmaniasis, developed at the Scientific Research Institute of Medical Parasitology named after L.M. Isayev. -
Epidemiological features of epilepsy according to the age and gender in rural districts of samarkand regionPurpose: carry out analysis of the morbidity frequency of epilepsy and its prevalence according to the age and gender in rural districts of Samarkand region. Materials and methods: objects of research has served the territory of four rural districts of Samarkand region, which determined the incidence and prevalence of epi-lepsy. Results: Analysis of the morbidity of epilepsy in this population showed that the annual rate of total mor-bidity was higher than the indices of the previous years, designed on the basis of anamnesis. Conclusions: analysis of the prevalence of epilepsy according to the age showed a gradual increase of infestation of epilepsy in the middle age groups, with a peak in the group of 44-60 years and a gradual reduction from the sixth dec-ade
Journal problems of biology and medicine -
Comparative characteristics of the occurrence of myocardial infarction With age, gender, professional supplies and seasonality of the yearRecently, the growth of myocardial infarction has increased among diseases ot the cardiovascular system. Mortality in myocardial infarction has doubled. From this point of view, it was of great interest to study in the conditions of Samarkand the connection of the disease with sex, age, professional affiliation and seasonality of the year. It was found that the disease among men aged 40-69 years is common, and people engaged in physical labor arc less likely to get sick. By the seasons it is established that in the winter admission to the hospital increases. Overall mortality was 21.2%. Of these, 64.4% among men and 35.6% among women. These data serve a significant role in preventing the disease.
Doctor's Herald -
Results and features treatment the diaphyseal fractures of both forearm bones in childrenTreatment of children with fractures of bones of a forearm is an urgent and complex problem. The analy-sis of treatment of the closed fractures of bones of a forearm at 118 patients is made. The patient has applied conservative treatment (a one-stage manual repozition and an immobilization with plaster steak) and expedi-tious treatment (an open repozition, an intramedullary osteosynthesis and an immobilization with plaster steak) methods. Renewal of working capacity has happened in 71,4% of cases. It has become possible thanks to a combination of terms of treatment to the rehabilitation period, and also use improved a method of expeditious treatment. The correct comparison of bone fracture, their reliable fixing, early adequate functional loading is the main principles of treatment of fractures of forearm. Studying results of clinical application of a way a one-stage manual repozition and an intramedullary osteosynthesis of fractures of bones of a forearm at children is given in article. Studied and improved ways treatment provides increase in rigidity of fixing of bone fragments, prevents deformation, promotes to successful result.
Journal problems of biology and medicine -
Efficiency of medical and non-educational of prophylactic development Measures for non-infectious diseases in children from risk groupThe problem of chronic non-communicable diseases is now attracting widespread attention due to the threatening trends in the incidence of morbidity, disability, and mortality from these diseases, both in childhood and in adulthood. This article reveals questions on maintaining a healthy lifestyle, recommendations on non-drug therapy of non-communicable diseases, including physiotherapy methods.
Doctor's Herald -
Hepatic encephalopathy is a common complication of liver dysfunction, including acute liver failure and liver cirrhosis. Hepatic encephalopathy presents as a spectrum of neuropsychiatric symptoms ranging from subtle fluctuating cognitive impairment to coma. It is a significant contributor of morbidity in patients with liver disease. Hepatic encephalopathy is observed in acute liver failure, liver bypass procedures, for example, shunt surgery and transjugular intrahepatic portosystemic shunt, and cirrhosis. These are classified as Type A, В and C hepatic encephalopathy, respectively. Hepatic encephalopathy can also be classified according to whether its presence is overt or covert. The pathogenesis is linked with ammonia and glutamine production, and treatment is based on mechanisms to reduce the formation and/or removal of these compounds. There is no specific diagnostic test for hepatic encephalopathy, and diagnosis is based on clinical suspicion, excluding other causes and use of clinical tests that may support its diagnosis. Many tests arc used in trials and experimentally, but have not yet gained universal acceptance. This review focuses on the definitions, pathogenesis and treatment of hepatic encephalopathy. -
The close relationship of physical health and neuroendocrine status of women, structural and functional usefulness of the uterus, placenta, and fetal development in accordance with the course of gestation cause difficulties in determining the root cause of preterm labor. We can assume that at some point the threat of premature birth in the system of mother-fetus develop processes of a pathophysiological entity which can be judged on the basis of research on the state of the autonomic nervous system of the mother and fetus. Such opportunities are incorporated in the method of functional diagnostics - cardiointervalography (K.I.G). -
Studying of prospective diagnosis at cardiointervalography at threat of premature birthsThe listed functional and laboratory methods of research of hemodynamics of the pregnant woman which are widely used now, state availability of structural changes, to a lesser extent reflecting functional parameters of homeostasis. Before these methods the method of the analysis of variability of cordial rhythm - cardiointervalography, information value and which opportunities allow to explain pathophysiological state from interaction position among themselves of functional elements of vegetative nervous system that is actual and low-studied has advantage. Comparison to clinical and paraclinic indicators the cardiointervalography gives the grounds individually to carry out correction of disturbances with opportunity for prevention of obstetric and perinatal complications.
Doctor's Herald -
Prospective research of pregnant women with the asymptomatic bacteriuria in the i-ii trimesters of pregnancyAt the vast majority of women the traditional asymptomatic uroin fekt ion has been for the first time exposed at the first visit of clinic for women in 52,3%- Occurrence of asymptomatic bacteriuria at 2,5%-11,5% of pregnant women that aggravates development of pathology in mother and the newborn at 20-30 times. Preventive antibacterial therapy of asymptomatic bacteriuria prevents development of pyelonephritis in 70-80% of women.
Doctor's Herald -
Clinical and laboratory characteristic of manifestation of the nephrotic Syndrome at children according to the specialized nephrological departmentThe study included retrospective analysis of medical records of 68 patients aged 1 to 16 years (30 girls and 38 boys) hospitalized in the Nephrology Department of the regional children's multi-profile medical center (NDRChMPMC) with nephrotic syndrome. . The analysis of age features of debut of the nephrotic syndrome (NS) at children is carried out. The most frequent diagnosing of nephrotic syndrome at boys at the age of 2-5 years; identification of "pure" NS more often in children 1 - 3; 7 - 11 years and combination of NS with erythrocyteuria- patients till 1 year and under 11 years old.
Doctor's Herald -
The influence of melatonin on the functional state of the hepatobiliary system with dexamethasone-induced diabetesThe influence of melatonin on the functional state of the hepatobiliary system with dexamethasone-induced diabetes mellitus was studied. The analysis of numerous research studies made it possible to talk about the high prevalence of complications in diabetes as a disease of the liver, the principal organ of metabolic processes in the body. It was established during the experiment that diabetes reduced the intensity of bile, the number of total bilirubin in it, mainly due to its conjugated forms, cholates and cholesterol, which disturbed the relationship between the components of the bile. The injection of melatonin at a dose of 10 mg / kg intraperitoneally during 10 days lead to an increase in the intensity of bile secretion, increase the concentration of bilirubin in it, both general and conjugate fractions, cholates and cholesterol, improved the processes of conjugation, normalized cholate – cholesterol coefficient.
Journal problems of biology and medicine -
Cytomegalovirus infection (CMV) causes an acute interest to physicians of various specialties (infectionists, gynecologists, immunologists, pediatricians, dcrmatovcncrologists, etc.). This interest is due to a variety of clinical forms, manifestations and modes of transmissions of this infection. -
The role of the ultrasound sonography in acute colon obstruction and demonstration of possibility transabdominal sonography in diagnosis several other types of this pathology. Developed methods of ultrasound sonography for the patient with suspicion of intestinal colon obstruction and studied symptoms and possibility differentiation strangulated and obturated colon obstruction. Sensibility, information value and accuracy of ultrasound sonography in 75% cases shows necessity of using this method. -
With the increase in the frequency of cesarean delivery, there is a new problem - the management of pregnancy and delivery in women with a uterine scar. Most recurrent abdominal delivery is made on the assumption that the insolvency of the scar. The paper attempts to evaluate the accuracy of ultrasonography in comparison with intraoperative data consistency scar. It is found that the consistency of rumen confirmed in 83.3% of cases. The failure of the scar before the operation was suspected in 16 (32%) of pregnant women, which was the basis for rc-cacsarcan section, but only confirmed in 9 (56.3%).
