In the introductory part of the article the author characterizes relations on securities market. In the basic part of the article professional participants of Securities Market and legal regulation of their activity are considered. In the conclusion the author comes to opinion, that it is necessary to develop the operating national legislation,
concerning state regulation of securities market and relations concerning its participants.
Our results confirm the hypothesis that the presence of an unfavorable genotypic variant of the IL4 gene can lead to a violation of the synthesis (expression) of anti-inflammatory cytokines-interleukins, a decrease in the body's resistance to infectious diseases, and an increase in the risk of developing CPRS. In addition, these data emphasize the prognostic significance of the C/C genotype of the IL4 gene polymorphism in the development of CPRS. The relative risk of developing CPRS in carriers of these genotypes is more than 3 times higher than in carriers of other genotypic variants of IL4 gene polymorphism.
A review of retrospective data on the clinical cases of patients observed at the clinic of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology (RCCMCO&R) of the Ministry of Health of the Republic of Uzbekistan was conducted. During the examination, the clinical case of a patient from practice with atypical localization of the affected areas was isolated and described. The patient was diagnosed with a B-cell variant of lymphoma (B-LBL) with damage to the bone marrow and skeleton bones. High risk. The duration of verification of the diagnosis of BLBL was 5 months, as a result, the patient received inadequate therapy, and the disease progressed, which ultimately negatively affected the outcome of his treatment. Tumor lesion of the skeletal system was a characteristic feature in B-LBL (11.1%), while in the T-cell variant of lymphoma (TLBL), it did not occur. Despite this, this indicator was not reliable in this clinical case.
The article deals with the issues of improving the efficiency of banks with overdue debts. The most effective methods of reducing the risk of problem loans, eliminating their occurrence factors and improving the loan portfolio are identified. The analysis of existing problem loans in the loan portfolio was also carried out and gave practical suggestions for their elimination.
Подростковый возраст считается неблагополучным в отношении туберкулеза, что связано с физиологическими, психологическими и социальными особенностями подростков. Сопутствующие заболевания - фактор, снижающий резистентность иммунной системы и реализующий риск развития туберкулезной инфекции.
Stroke has remained the most important medical and social problem for many years. According to the WHO, of the number of stroke survivors, only half remain functional. Cognitive impairments of varying severity occur in a significant number of patients with acute cerebrovascular accident, and slow down the process of functional recovery, increase the risk of recurrent stroke and death. In the recovery period of a stroke, both regression and a significant increase in cognitive deficit are possible. The prevalence of im -paired cognitive functions in the population associated with vascular diseases of the brain has a significant impact on the state of so - ciety as a whole and is one of the most pressing medical and social problems that cause impaired adaptation in the professional, social and domestic spheres.
Повышенный риск инфекции полости рта, особенно кандидоза. Боль при глотании, ограничения в диете, повышенная потребность организма в белке и поражение желудочно-кишечного тракта ведут к нарушению питания и, как следствие, к задержке развития, анемии и медленному заживлению ран. Выявляемые отдаленные осложнения в виде анкилоглоссии, микростомии, облитерации преддверия рта, скученности зубов и глубокого прикуса, связаны с прогрессирующим рубцеванием мягких тканей СОПР.
The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
This article examines and describes the number of issues related to modern treatment of translation competence and properly studies its main components. The article makes the analysis of translation competence components, their correlation and influence on the profession. The competences will enable to improve the quality of translators training and to increase the level of the education provided.