Aim of the study.To assess the degree of endothelial dysfunction and renal function in experimental ischemic stroke (EIS) in rats on the dynamics of pharmacotherapy.Materials and Methods.The subject of experimental studies were 105 adult mongrel white male rats. The object of the study were the serum and urine of rats. The model of cerebral circulation reproduced by temporary clipping of the left common carotid artery. The controls were 20 intact animals. Results. The results indicate to the development of endothelial dysfunction with EIS with the activation of neoangiogenesis in experimental animals. Pharmacotherapy with suksinasol for 7 days caused reduction of the level of ET-1 with respect to the values of untreated animal group and was still significantly higher than control group of rats in 2.5 times. At the same time, the level of VEGf A (vascular endothelial growth factor A) significantly decreased respectively to untreated group of rats in 1.65 times (p<0.01), but was still higher than control values in 1.74 times (p<0.01). development of proteinuria, microalbuminuria and creatininuria in rats with EIS apparently was due to the development of hemodynamic changes in the kidney and glomerular basal membrane permeability, and due to the enhanced excretion of toxins and protein degradation products.Conclusion. The endothelial and renal dysfunctions with activation of neoangiogenesis develop on the model of EIS. Pharmacotherapy corrects the identified changes to some extent. Tivortin and choline alfosceratewere more effective, possibly, because of decrease of hemodynamic disturbances and neurotrophic effects.
This article analyzes the role of political parties in the formation of state bodies (legislative and executive branches), the positive features of a multi-party system, the place of political parties and elections in the formation of civil society, reforms in the electoral system, the electoral function of political parties, and the place of the electoral platform
The article discusses controversial issues and difficulties of the methods of examination of the cardiovascular system in the study of propaedeutics of internal diseases by students based on the retrospective analysis of academic history cases. Physical examination methods – questioning, inspection, palpation, percussion, auscultation, have not yet lost their significance when making a diagnosis and require special attention when teaching medical students.
This article focuses on translation practice that helps students acquire, develop, and strengthen their knowledge and skills in a foreign language. Translation integrated into the practice of language learning along with generally accepted learning activities such as reading, listening, writing and vocabulary development can be described as a “pedagogical tool” as its purpose is language learning. Translation activity forces students to communicate in two directions: from a foreign language and into it. During translation, students are encouraged to notice differences in structure and vocabulary, strengthen grammatical skills, shape their own way of thinking, and correct common mistakes that might otherwise go unnoticed. Students can get the most out of their learning if they are encouraged to use their translation skills correctly. Translation is a good tool for learning a foreign language.
Питание человека – одна из наиболее важных задач.Оно имеет принципиальное отличие от всех остальных загадок природы. Питание является важнейшей физиологической потребностью организма. Для построения и непрерывного обновления клеток и тканей, для восполнения энергетических затрат организма необходимо питание. С давних времен люди понимали огромное значение питания, они считали еду источником здоровья и силы, а также бодрости. С учетом условий жизни, труда и быта правильное питание обеспечивает постоянство внутренней среды организма человека, деятельность различных органов и систем и, таким образом, является непременным условием хорошего здоровья, гармоничного развития, высокой работоспособности.