The article is devoted to the demographic problems of Japan. According to estimates of the future population by the National Institute for Demography and Social Security every five years, based on the results of the census, the total population of Japan, reaching a peak of 128 million in 2010, began to decline, and it is estimated that in 2040 it will amount to 107 million 280 thousand people a year. According to the calculations of the Ministry of Land, Infrastructure, Transport and Tourism, in 2050 the population will decrease to 97 million people, falling below the level of one hundred million. The decline in population poses a threat to the development of society from various points of view, even if you do not run so far ahead. Due to the decrease in the working-age population (from 15 to 64 years), hidden growth opportunities disappear, and GDP decreases. It becomes difficult to maintain a social security system, and in particular a pension system. There are fears of declining living standards. The author considers such specific trends in the demographic development of Japan as the rapid aging of the population, the drop in the birth rate, as well as the impact of these processes on the quantitative and qualitative characteristics of the workforce and possible ways to replenish it. In the analysis of the problems considered in the article, it is concluded that the demographic crisis faced by Japan will certainly have a noticeable negative impact on economic development, but it is likely that the country's ruling circles will be able to mobilize the nation and mitigate the effects of demographic shifts.
The presence of problems associated with demographic processes in Uzbekistan creates certain problems in the employment of labor resources. At this stage, it should be noted that the demographic situation is a complex socioeconomic process that characterizes the dynamics of the country's population, population overproduction, changes in the family structure, population migration, national and social composition of the population and changes in it. Important conditions for the formation of rational employment of the population are carried out on the basis of the following criteria: free choice of work and place of residence, the abolition of various administrative restrictions on the mobility of the population, the provision of a guarantee of employment with strict observance of labor laws. Abstaining from forced labor means that every person has a free choice - to work in social production or not. In this case, it is assumed that the legal implementation of labor activity will undoubtedly allow employees to be hired through the labor market and compete among themselves for their best conditions. According to the criteria presented, it is not enough for employees to be officially free. In order for hired labor to be effective, economic conditions and social guarantees are necessary. These include the fact that the minimum wage required for an average per capita working day is established by law, and the abolition of income restrictions for workers is the main one. One of the main demographic sources for the formation of rational employment of the able-bodied population is the expansion of its economically active part. The employment of the economically active population reflects its movement in the unity of interrelated economic and socio-demographic processes
The aim of the study was clinical and functional assessment of the effectiveness of the drug "Lutein Ophthalmo" in treatment of age-related macular degeneration . We observed 40 patients (80 eyes ) aged from 55 till 80 years , with the age- related macular degeneration , which were divided into 2 groups. The first group (control ) - 20 people (40 eyes) who received conventional therapy . The second group ( basic) - 20 people ( 40 eyes ) who received conventional treatment in addition to the preparation of 500 mg "Lutein Ophthalmo" leap x 2 times daily for 30 days. During the spent treatment in the basic group of patients visual acuity improvement, reduction relative scotomas and with preservation of a condition of a retina of stable effect is noted indicators. All of this allows us to recommend "Lutein Ophthalmo" in treatment age-related macular degeneration
Бугунги кунда мавзули карта ва планларни яратиш, уларни қайта ишлаш, маълумотлар базаларини шакллантириш, интегрaциялаш ҳамда визуаллаштириш каби ишлар ГАТ технологиясининг асосий мақсадли вазифаларидан бири деб қабул қилинди. Электрон демографик карталарини тузишда маълумотларини тўплаш, уларга мувофиқ маълумотлар базасини шакллантириш ишлари ArcGis, MapInfo, Panorama, GeoDraw, GeoGraph, Atlas Gis, Win Gis, ArcInfo ва бошқа дастурлар асосида олиб борилмоқда. Ушбу мақолада электрон карталарини тузишда маълумотлар тўплаш ва унда замонавий методлардан фойдаланиш, фазовий маълумотларни ГАТларда интегрatsiялаш ҳамда ижтимоий-иқтисодий карталарни тузиш ишлари юзасидан фикр-мулоҳазалар келтирилган.
Topicality and demand of the subject of dissertation. Researches of human population genomic variety and scenarios of its genetic pool formation arc one of perspective directions of modem genetics. Prompt progress in this field has allowed defining the basic routes of continents settlement. However the information about Central Asian (CA) populations even on «classical» genetic markers has accidental, fragmentary character, and requires additional large-scale investigations. Besides, according to historical, archeological, paleontological and some anthropogenetic studies, given region was playing certain role in ancient moving of modem human ancestors throughout Eurasian continent. Therefore it is extremely important to summarize and perform complex assessment of new and collected data on Central Asian populations as practically there arc no multivariate analyses studies of given region as a complex population system.
In studies of human population genetic structure arc usually used various approaches allowing understanding concept of populations subdivision and character of genetic relationships between them. Among these techniques the prominent place belongs to approaches based on an assessment of genetic distances between populations with their subsequent analysis by multivariate statistics methods. For even more compelling picture of the relationships between the populations on tree diagram we composed «the genetic landscape» of area, where the description of population genetic structure is presented by equally spaced figures consistently consolidating populations according to their genetic distances from each other and thus creating a genetic landscape. This approach is not only a tool for elementary population boundary detection, but also can be effectively used for identification of borders and sizes of population as naturalistic unit.
Multigcnctic landscape is a collection of different genetic systems which arc specific to the region and ethnic groups, which have their geographical areas, their geographical, historical and cultural boundaries. Gene flows arc run through these conventional boundaries, but they arc less intense than in the limits of area. These limits arc ambiguous and fluid, but it is real. You can identify them by studying, for example, the structure of marriage migration. Therefore anthropogenesis of different populations will inevitably differ from each other. Ethnogenetic composition tends to change over time, from generation to generation, and hence there is a need to understand the structure of the genepool, not only at a given time, but also in the study of genetic processes that form and reform the gcncpooL In this regard, the studying of multigcnctic landscapes is in close contact with the demographics, medical and genetic ecology, anthropology, ethnology, archeology and history of the peoples, that is, with a range of areas, not only natural, but also the humanities knowleges.
Study of genomic diversity is important not only to address questions of origin and genetic history of different ethnic groups, but is also the basis for molecular epidemiology of hereditary and multifactor diseases. Each region is characterized by a specific set of common genetically determined diseases. To understand the causes of the prevalence of disease in different regions, and to develop approaches to their early DNA diagnosis and effective prevention, initially it is necessary to conduct population-based studies, which determine the development of the disease.
Purpose of research is to implement a comprehensive description of the structure of indigenous Central Asian populations genetic pool, examine demographic, phylogenetic and evolutionary features of Central Asian populations through the analysis of genetic variety of mtDNA, Y-chromosomal (NRY), autosomal, X-chromosomal microsatcllites and immunogcnetic variants of Helicobacter pylori (H.pylori) and hepatitis В virus (HB V).
To achieve this goal the following tasks of research is solved:
specification of immunogcnetic variants of H.pylori and HBV, allocated at the patients in Central Asian region, with the subsequent comparative phylogenetic analysis of H.pylori and HBV regional versions with those in other regions of the world;
examination of genetic variety and degree of genetic differentiation of Central Asian populations according to classical population-genetic objects -polymorphisms of mtDNA, Y-chromosomal, autosomal and X- chromosomal STRs;
assessment of the Western and East-Eurasian lines of population inheritance contribution to Central Asian populations’ genetic pool at regional, ethnic, sub-cthnic levels and in a level of elementary populations;
reviewing of character of regional populations relationships by genetic variety of mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers in view of ethnographic, social and linguistic data;
evaluation of sex-specific genetic structure and the social organization according to polymorphisms of mtDNA, autosomal, X-chromosomal, Y-chromosomal markers in the region;
determination of ancient ways of migrations and scripts of formation of Central Asian populations according to mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers and immunogcnetic variants of H.pylori and HBV',
evaluation of ethnogenetic position of studied Central Asian populations in the system of genetic pools of Eurasia and the world in general through comparative analysis of all studied population-genetic parameters.
Scientific novelty of dissertational research consists in the following:
for the first time was performed a study of genetic pool structure of 26 Central Asian populations from 6 ethnic groups as complete population systems using a wide range of genetic objects;
for the first time was made an assessment of informativeness of each type of genetic subjects. For the first time was received detailed characteristic of genetic pool structure of indigenous Central Asian population on the basis of variability lines of the spectrum of genetical objects;
for the first time was defined the ratio of Westem-and the East-Eurasian lines in a genepool of Central Asian population and were made an assessments of genetic variety level and genetic differentiation degree of regional populations as a whole;
for the first time phylogenetic analysis of major haplogroups of investigated genetic subjects was conducted;
for the first time the position of Central Asian population in population genetic pool system of surrounding regions and Eurasia in the whole was studied;
for the first time the evolutionary-adaptable mechanisms, necessary in the forecast of formations of multigenic pathologies in region were studied at 6 ethnoses of Central Asian.
CONCLUSION
1. H.pylori from Central Asian territory is similar to Western Europe isolates, and shaped by two ancestral populations genotype Ancestral Europe 1 (dominant) and Ancestral Europe2 and for AE1-genotype Central Asian region probably is the source. H.pylori from the territory of Central Asia form a separate cluster group: close relationship of Tadjik, Uzbek strains and Iranian isolates from the north of Iran is established. Kirghiz isolates were found to be closer to populations from territory of Siberia.
2. High diversity of HBV genotypes in Central Asia was found -4 genotypes (A, C, D, and G). Phylogenetic analysis of Central Asian genotype HBV-with options for other regions of the world showed a close relationship between the dominant genotype D (0,78), the D1-subtype with variants of the virus in Europe, the Middle East and Africa.
3. The rates of genetic affinity for STR-NRY in Kazakhs, Turkmens, Karakalpaks Turtkul at the level of the same lineage were high: 0,58 (p<0,001); 0,34 (p<0,01) and 0,77 (p<0,001), respectively. The coefficients of relationship at the level of clan for Kazakhs, Turkmens, Uzbeks and Karakalpaks from Kungrad and Turtkul were lower: 0,30 (r<0,01); 0,21 (p<0,001) and 0,40 (r<0,001); 0,07 (p<0,05) and 0,09 (p<0,05), respectively. At the level of the tribe, the indicators were negative for all Turkic populations: -0,02 (r<0,05);-0,04 (r<0,001);-0,07 (p<0,01); -0,0011 (r<0,1) and -0,10 (r<0,01), respectively.
4. The analysis of mtDNA HVS-1 showed that total rate of differentiation level for all populations was low: FST=0,013; p<0,0001. Level of diversity between groups was 0,6% (p<0,001) of the total variability. Parameter of genetic differences between Turkic and Indo-Iranian populations made 0,55% (p<0,0283) of the total genetic variability. The rate of genetic differentiation on a sub-ethnic level was significantly expressed in Indo-Iranian group (FST=0,0197;r<0,001) than among the Turkic-speaking (0,3%; p=0,10). In all populations, in general, wasn‟t detected the correlation between genetic and geographic distances at the global level on mtDNA HVS-1: r=0,00682; p=0,502.
5. Analysis of STR-NRY showed that the level of the genetic differentiation between ethnic groups was 5,6% (p<0,02); general differentiation between populations made RST=0,186 (p<0,001). Combined analysis, taking into account the language and way of life of Turkic and Indo Iranian populations, showed the general differences between the two groups – 9,1% Value of genetic differentiation when comparing the ethnos-ethnos was slightly lower than the level within ethnos: 5,6% among ethnic groups, 18,6%, and 13,7%-between populations within the ethnic group.
6. Analysis of heterozygosity (H) and the average number of pairwise differences (p) of mtDNA, were high in nomadic populations (av.H=0,99; av.p=5,29) and farmer populations (av.H=0,99; av.p=5,32). Heterozygosity (H) on Y- chromosome was lower in nomadic groups than in the agrarian – 0,86 and 0,99,respectively (p<0,01). Nomadic populations exhibit a higher level of population differentiation (RST) in comparison with farmers - 0,19 and 0,06, respectively (p<0,01). Indicators of population growth (r) were lower in nomadic populations compared with farmers - 1,004 and 1,008, respectively (p=0,056).
7. The level of genetic differentiation in all ethnic groups was higher on the Y chromosome in comparison with mtDNA. The farming populations showed no significant difference in the genetic differentiation FST (Y)=0,069 and FST (mtDNA)=0,034, while among patrilineal nomadic population the level of genetic diversity was higher in the male line of inheritance - FST(Y)=0,177 and FST (mtDNA)=0,010. Genetic diversity of population structure in patrilineal nomads on autosomal and X-linked markers were: FST (A)=0,008 (0,006-0,010) and FST (X)=0,011 (0,001-0,004) (H0: FST(A)=FST(X); H1: FST(A)>FST(X); p=0,02). In bilinear farmer populations the differences of autosomal and X-chromosomal markers were insignificant: FST (A)=0,014 (0,012-0,016) and FST (X)=0,013 (0,008-0,018 at p=0,36).
8. Analysis of mtDNA indicated that the age of expansion on the territory of Eurasia (τw) declined significantly from East to West (r=0,72; p<0,001). The age of expansion had a pronounced tendency to decrease from 30 thousand years in China to 17 thousand years in Western Europe. Age of expansion in Central Asia amounted to 26 thousand years. Results of expansion analysis on NRY also show a decrease in genetic diversity from the East to the West of Eurasia (r=0,49; p<0,001). In Central Asia this age was 16 thousand yrs. According STRs-NRYBatwing analysis of the minimal age of Uzbek population origin was 1232,71 yrs old (Ne=14088 (6765-23942); α=0,0108 (0,0065-0,0155)).
9. The apportionment of multilocus genetic variations among ethnic and linguistic groups of Central Asian populations showed that more than 98% of all variations were within the population (p<0,0001). Evaluation of the ethnic and linguistic affiliations in the observed variations showed reliable conformity - FST=0,007; p<0,0001 and FST=0,011; p<0,0001, respectively. We didn‟t find evidence of geographical isolation within each of the Turkic and Indo Iranian groups of populations (p=0,363 and p=0,772, respectively).
10. Analysis of multilocus allelic diversity (AR) and heterozygosity (He) showed differences among the Central Asian and other populations in allelic variety (χ2 =105,29; d.f.=25; p<0,0001) and heterozygosity (χ2=67,98; d.f.=25; p<0,0001). Population differentiation at multilocus analysis at populations of Central Asia is more pronounced than in the other regions of Eurasia: in European and Middle Eastern groups pairwise estimation of FST ranged from 0,011 to 0,015 and -0,008-0,021, respectively; in East-Asian groups from -0,011 to 0,046; and finally, in Central Asia these rates ranged from -0,004 to 0,056. Heterozygosity was significantly higher in the group of the Indo-Iranian populations than among Turkic-speaking (He=0,818 and He=0,787, respectively; Z=-4, 55; p<0,0001). According to multilocus analysis all 26 Central Asian populations slightly but significantly differed (FST=0,015; CI99%=0,011-0,018; p<0,01).
Жиноят содир этилиб, уни содир этган шахс номаълум бўлса, бу жиноят фош этилмаган жиноят ҳисобланади. Жиноятчиликка қарши кураш олиб борувчи органлар фаолиятининг ташкилий шаклларини такомиллаштириш билан боғлиқ соҳалар ичида очилмаган жиноятлар бўйича ишларни тергов қилиш устидан идоравий процессуал назоратни келтириш мақсадга мувофиқ. Жиноят содир этган шахс номаълум бўлганда, яъни ЖПКнинг 364-моддасининг 1-бандида кўрсатилган асослар бўйича тўхтатилган жиноят ишлари ҳозирги пайтда йилдан-йилга рўйхатга олинган жиноятлар ичида кўпайиб бормоқда. Демак, ҳуқуқни муҳофаза қилувчи органларнинг жиноятларни очилиши билан боғлиқ фаолияти самарадорлиги айнан шу кўрсаткич билан чамбарчас боғлиқ бўлганлиги сабабли, бу ҳолат терговчиларнинг фаолиятида ҳам, айниқса жиноятларни очилишини ташкил этувчи рақамларга ҳам бевосита таъсир кўрсатади, чунки бу рақамлар улар томондан тегишли қарорлар қабул қилишда юзага келади. Таъкидлаш жоизки, терговчи жиноятларни очиш функциясини амалга ошириб, тегишли процессуал ҳаракатларни амалга оширади ва бу ҳаракатлар инсоннинг ҳуқуқ ва эркинликларига тегишли бўлиши мумкин, бу эса дастлабки тергов даврида шахснинг ҳуқуқларини таъминлашда алоҳида эътиборни қаратилишини талаб этади. Ўтган йилларнинг очилмаган жиноятлар очиш фаолияти терговчи ва суриштирувчи органга тегишли бўлиб бунда шахснинг ҳуқуқларига сезиларли дара- жада таъсир кўрсатилади. Маълумки, ички ишлар органлари шахс ҳуқуқлари ва эркинликларини, жамоат тартиби ва фуқаролар хавф- сизлигини ҳимоя қилишнинг ишончли гарови бўлиши лозим.