Stroke has remained the most important medical and social problem for many years. According to the WHO, of the number of stroke survivors, only half remain functional. Cognitive impairments of varying severity occur in a significant number of patients with acute cerebrovascular accident, and slow down the process of functional recovery, increase the risk of recurrent stroke and death. In the recovery period of a stroke, both regression and a significant increase in cognitive deficit are possible. The prevalence of im -paired cognitive functions in the population associated with vascular diseases of the brain has a significant impact on the state of so - ciety as a whole and is one of the most pressing medical and social problems that cause impaired adaptation in the professional, social and domestic spheres.
Бош мия қон-томир касалликлари тиббиётда ва иж тимоий ҳаётда долзарб муаммолардан бири бўлиб келмоқда. Ер юзида ЖССТ берган маълумотга кўра ҳар йили 15 млн.дан ортиқ аҳоли инсульт ташхиси билан рўйҳатга олинади, шуларнинг ярмидан кўпида 1 йил давомида ўлим ҳодисаси кузатилади. Тирик қолганларнинг 80%дан ортиғида ногиронлик келиб чиқади (27,26,19). Дастлабки 1-йилда инсульт ўтказганларнинг 5-25% ида қайта инсульт кузатилади, кейинги 5 йилда эса 20-40% беморларда кузатилади ( 21,8.). Такрорий инсульт натижасида эса 95-100% беморлар ногирон бўлиб қолишади ва уларнинг 65-80% и бегоналар ёрдамига мухтож бўладилар. 70% касалларда эса психик бузилишлар кузатилади (28). РАМН(РТФА) берган маълумотларга кўра ишемик инсульт(ИИ) билан касалланган беморларнинг 84,5% и 55 ёшдан юқори бўлган беморлар, эркаклар орасида бу кўрсаткич 40-55 ёшда 30% ни, аёллар орасида эса 40-60 ёшда 46,2% ни ташкил этади (6). Охирги йилларда инсультнинг бундай ёшариши бу муаммони нг долзарблигини янада оширмоқда.
Нарушения мозгового кровообращения являются чрезвычайно актуальной неврологической проблемой. Пациенты с цереброваскулярной патологией составляют до 20% неврологических больных, при этом 23% из них перенесли ишемический инсульт (ИИ) [1].
Cardiovascular pathology and acute cerebrovascular accident (ACV) are in first and second place, respectively, as the causes of mortality in the structure of general mortality of the population. In this regard, interest in the issues of cerebral blood flow disorders does not weaken all over the world, more and more new aspects of this problem are being considered. CVA is a widespread pathology in the world and according to the WHO “... about 17.5 million people die every year from cerebrovascular diseases in the world, which is 30% of mortality from all diseases ...”. The most severe form of vascular pathology of the brain is a stroke. In European countries, mortality from stroke varies from 63.5 to 273.4 people per 100,000 population per year. About 85-88% of cerebral strokes are ischemic in nature. Ischemic stroke in developed countries ranks first as a cause of permanent disability. Movement disorders of varying severity are the most common and severe consequences of strokes.
Инсульт является чрезвычайно распространенным заболеванием. В Узбекистане заболеваемость мозговым инсультом колеблется от 0,9 до 1,4 на 1000 населения, а в г.Ташкенте 1,5 на 1000 населения. В последние годы происходит увеличение числа лиц, перенесших инсульт, одновременно с этим снижается летальность при этом заболевании. В настоящее время подходы к восстановлению больных после инсульта многообразны и включают восстановление как двигательных расстройств, так и высших психических функций.
Провести анализ литературных источников, посвященных развитию повторных ишемических инсультов у больных, перенесшихCOVID-19.
We analyzed the incidence of various types of stroke and studied the epidemiology of ischemic stroke subtypes using the example of one neurological unit. The most common was the atherothrombotic type of ischemic stroke, the least common being the hemodynamic type. The greatest risk of occurrence of ischemic stroke of various types was in persons with hypertensive disease, tobacco users with excessive body weight, the probability of ischemic stroke is higher in autumn and spring.
This article describes a study of 64 patients with various forms of cerebrovascular pathology. We studied the prognostic aspects of cognitive impairment in the development of ischemic stroke in patients with TIA on the background of chronic ischemia of the brain. Particular importance is given to the prediction and development of stroke. The data of instrumental and non-instrumental research methods in 64 patients were analyzed. Although we analyzed the most important risk factors for the development of ischemic stroke besides previously known factors.
The article reviewed frequency of types of stroke among the population of Ferghana valley, at once analyzed structure of background diseases, which played the main role in the progression of stroke. An analysis of the case histories of patients hospitalized with a stroke diagnosis at the Andijan branch of the RSCEM from January 2018 to January 2019 was performed. Among 1243 patients, there were 607 men and 636 women, whose average age is 62.45 ± 2.9 years. Ischemic stroke was detected in 56.1% of cases, hemorrhagic in 12.4%, and transient cerebrovascular accident in 31.5%. The main underlying disease for the progression of stroke were arterial hypertension - in 70,4%, cerebral atherosclerosis - in 14,1 and coronary heart disease - in 7,4% of patients.
Systemic lupus erythematosus is a chronic disease with multiple defects of immune regulation. The prevalence of systemic lupus erythematosus varies from 12.5 to 40 per 100000 populations, with predominance among women of reproductive age. Nervous system impairment in systemic lupus erythematosus occurs in 25 to 83% of cases of SLE and is associated with vasculopathy, thrombosis and hemorrhages, and direct damage to brain tissues with antibodies. The article presents a summary of clinical observation
The results of the screening for the study of risk factors for the development of cerebrovascular diseases and stroke are presented. When identifying the degree of risk of development, a special questionnaire was used, which included the Fedin outpatient scale, the Mini COG test, and also took into account cholesterol and blood sugar, blood pressure, body mass index, and auscultation of the carotid artery. A low risk of developing CVD and stroke was found in 45%, medium - in 33%, high - in 22% of the examined
Инсульты одна из важнейших проблем общества, являются основной причиной длительной инвалидизации больных. Ежегодно в мире регистрируются более 15 млн инсультов.
Aim of the study.To assess the degree of endothelial dysfunction and renal function in experimental ischemic stroke (EIS) in rats on the dynamics of pharmacotherapy.Materials and Methods.The subject of experimental studies were 105 adult mongrel white male rats. The object of the study were the serum and urine of rats. The model of cerebral circulation reproduced by temporary clipping of the left common carotid artery. The controls were 20 intact animals. Results. The results indicate to the development of endothelial dysfunction with EIS with the activation of neoangiogenesis in experimental animals. Pharmacotherapy with suksinasol for 7 days caused reduction of the level of ET-1 with respect to the values of untreated animal group and was still significantly higher than control group of rats in 2.5 times. At the same time, the level of VEGf A (vascular endothelial growth factor A) significantly decreased respectively to untreated group of rats in 1.65 times (p<0.01), but was still higher than control values in 1.74 times (p<0.01). development of proteinuria, microalbuminuria and creatininuria in rats with EIS apparently was due to the development of hemodynamic changes in the kidney and glomerular basal membrane permeability, and due to the enhanced excretion of toxins and protein degradation products.Conclusion. The endothelial and renal dysfunctions with activation of neoangiogenesis develop on the model of EIS. Pharmacotherapy corrects the identified changes to some extent. Tivortin and choline alfosceratewere more effective, possibly, because of decrease of hemodynamic disturbances and neurotrophic effects.
Оценка двигательных, когнитивных расстройств у пациентов с ХСМН и оценка их динамики после проведения курса реабилитации.
У шбу лойиха Ўзбекистон Республикаси Президенти нинг “2017-2021 йилларда Ўзбекистон Республикаси ривожланишининг беш устувор йўналишларида ҳаракатлар стратегиясини амалга ошириш Давлат дастури тўғрисида" ги фармони [1,4], "Фан, таълим ва рақамли иқтисодиётни ривожлантириш йили " ва "Рақамли Ўзбекистон – 2030" дастури [2,4]; 2018 йил 30 августдаги ПП-3925 сонли "Аҳолига неврологик ёрдамни ошириш чора-тадбирлари тўғрисида" [3,4] ва шу соҳага оид бошқа меъёрий-ҳуқуқий ҳужжатлар доирасида амалга оширилади.
Выявление ранних признаков и предотвратить риски развития цереброваскулярных заболеваний у лиц старше 40 лет.
At present, the cerebral circulation disorder is caused by various factors. According to the Ministry of Health of the Republic of Uzbekistan, 62876 cases of strokes were registered in Uzbekistan in 2019. 15% acquired lethal outcome, 10-15% returned to their previous state, 55 - 70% became disabled. Stroke is translated from the Latin language as a "stroke" which means an acute cerebral circulation disorder. Regardless of the cause of cerebral circulation disorder, the result is always the same - the death of brain neurons. The most common cause is atherosclerosis on the inner walls of blood vessels that supply the brain. They narrow the blood vessels and make them less flexible. In this case, the probability of clogging the blood vessels with blood clots increases, as a result, the blood vessels cannot supply blood to the brain.