The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
This article contains the results of the introduction, as part of experimental training, of the methodology developed by the author in the process of studying the issue of linguodidactic features of consecutive two-way interpreting. The article describes the prerequisites for the study, the interpretation of the term "translation ”, as well as some psycholinguistic features and characteristics of the mechanisms of consecutive translation activity. The relevance of the study is due to the fact that dramatic changes taking place in various areas of our society have led to the need to improve the quality of professional training of qualified specialists - namely, competent consecutive translators. The purpose of the article is to show the effectiveness of the developed methodology by describing the results of an experimental test of senior (3-4) students of language universities of translation faculties. Particular attention is paid to mathematical analysis and calculation of results. Theoretical methods are used: the study and analysis of pedagogical, psychological psycholinguistic literature, literature on the problems of speech, creative and cognitive activity, literature on the theory and practice of translation, analysis of the content of teaching consecutive interpreting in senior courses of a language university; empirical -observation of the educational process at the faculty of theory and practice of translation; student testing; questioning of teachers and students; conducting a training experiment, systematization and synthesis of experimental data, their interpretation. The research results consist in the fact that the specifics of consecutive two-way interpreting are disclosed to some extent, the mechanisms of memory operation in the interpretation process are described, the results of using the methodology developed by the author for teaching consecutive interpreting in conditions that are close to real by using it in teaching senior students (3-4) in language universities are presented. The author's view on teaching consecutive interpreting will be of interest to specialists both in the field of translation studies and in the field of methodology.
This monograph contains the results of the implementation, within the framework of experimental training, of the methodology developed by the author in the process of studying the issue of linguodidactic features of consecutive two-way interpretation. The monograph describes the prerequisites for the study, options for interpreting the term "interpretation", as well as some psycholinguistic features and characteristics of the mechanisms of consecutive interpretation activity. The relevance of the study is due to the fact that the fundamental changes taking place in various areas of our society have led to the need to improve the quality of professional training of qualified specialists - namely, competent consecutive interpreters. The purpose of the monograph is to show the effectiveness of the developed methodology by describing the results of experimental testing of students of senior (3-4) courses at translation faculties of language universities. Particular attention is paid to mathematical analysis and calculation of results. Theoretical methods used are as follows: the study and analysis of pedagogical, psychological psycholinguistic literature, literature on the issues of speech, creative and cognitive activity, literature on the theory and practice of translation, analysis of the content of teaching consecutive translation at the senior courses of a language university; empirical - observation of the educational process at the Faculty of Translation; student testing; questioning of teachers and students; conducting a teaching experiment, systematization and generalization of experimental data, their interpretation. The results of the study are that, to some extent, the specifics of consecutive two-way interpretation are disclosed, the mechanisms of memory work in the process of translation are described, the results of using the method of teaching consecutive interpretation developed by the author in conditions close to real by using it in teaching senior students (3- 4) at language universities. The author's view on teaching consecutive interpretation will be of interest to specialists both in the field of translation studies and in the field of methodology.
In this article, the application of pedagogical research results to the educational process is important and shows the effectiveness of the performed research work. The main goal of experimental work aimed at improving the content and effectiveness of teaching nuclear technology to students of higher educational institutions is that high indicators have been achieved in the formation of knowledge of nuclear technology among students of higher educational institutions. Experimental work was carried out during 2019-2022, and experimental and control groups were selected from among students of Tashkent Medical Academy at Samarkand State Medical University and Bukhara State Medical University.
В детском возрасте ведущей причиной ТМА является гемолитико-уремический синдром (ГУС), ассоциированный со шига токсином (типичный ГУС), атипичный ГУС, обусловленный дисрегуляцией системы комплемента (АГУС), тромботическая тромбоцитопеническая пурпура (ТТП), связанная с дефицитом ADAMTS-13. У ребенка грудного возраста можно встретиться с редкими генетическими причинами ТМА, такими как метилмалоновая ацидемия (ММА) с гипергомоцистеинемией, диацил- глицерол киназа эпсилон (DGK) – ассоциированная нефропатия. Диагностика причины ТМА чрезвычайно важна, т.к. своевременный старт комплемент-блокирующей терапии при АГУС, плазмотерапии при ТТП, метаболической терапии при ММА может спасти жизнь ребенка. Диагноз АГУС является клиническим и может быть установлен при исключении других причин ТМА.
В последнее время бисфосфонатная терапия широко используются в медицинской практике в качестве антирезорбтивных агентов благодаря их антиостеоклатическому действию.
The article reveals the role of the higher education system in the national economy. At the same time, a comparative analysis of traditional and modern views on the education system is carried out. A complex of factors affecting the quality of education was identified. The level of coverage of the higher education system in Uzbekistan and the existing imbalances in it were determined. The scientific conclusions and practical recommendations for improving the system of higher education are given.
Higher education institutions have a special importance in the society, because they are considered as the main foundation for the future generation of the society, and they can lead the society to progress or lead it to decline. That is why higher education institutions have a double responsibility to the people, the generation and the society. And this, in turn, should be aimed at justice, accountability, transparency, accountability and growth in the management of higher education institutions. And this is the principles of corporate governance.
This article is devoted to the study of the problems associated with the peculiarities of interaction between government, business organizations and social institutions in the management of higher education field. Recommendations to improve the mechanisms of public-private partnerships in higher education, present a proposal for the management of higher education, taking into account the level of competition in the market of educational services in the region.
This article discusses the problems of the impact of globalization on the development of higher education, as well as the development of the processes of integrating national education systems into a single global educational space, the growing trends of internationalization and competition in the field of higher education, and scientifically analyzes the fact that global integration and unification cover all areas of public life. Such fundamental changes are scientifically and practically based on the fact that competition in the field of goods and services is turning into competition in the field of cooperation and quality education. Also in this article, a comparative analysis of various levels of paradigmatic approaches to assessing the quality of higher education is carried out. In this regard, specific characteristics of the global, macro-regional, national, local levels of education quality assessment are substantiated, each of which contributes to the formation of a general system for assessing the quality of higher education, scientifically and practically substantiated.
Ushbu maqolada maktabgacha yoshdagi bolalar bilan asosiy harakatlarni tashkil qilish boyicha ma‘lumotlar keltirilgan.
In this article, the features of neurodynamic processes in students studying at the higher educational institution in situational sports, using the tapping test and the modified tapping test, identifying coordination abilities and indicators of asymmetry of “right-handed-left-handed” movements.