Topicality and demand of the subject of dissertation. Researches of human population genomic variety and scenarios of its genetic pool formation arc one of perspective directions of modem genetics. Prompt progress in this field has allowed defining the basic routes of continents settlement. However the information about Central Asian (CA) populations even on «classical» genetic markers has accidental, fragmentary character, and requires additional large-scale investigations. Besides, according to historical, archeological, paleontological and some anthropogenetic studies, given region was playing certain role in ancient moving of modem human ancestors throughout Eurasian continent. Therefore it is extremely important to summarize and perform complex assessment of new and collected data on Central Asian populations as practically there arc no multivariate analyses studies of given region as a complex population system.
In studies of human population genetic structure arc usually used various approaches allowing understanding concept of populations subdivision and character of genetic relationships between them. Among these techniques the prominent place belongs to approaches based on an assessment of genetic distances between populations with their subsequent analysis by multivariate statistics methods. For even more compelling picture of the relationships between the populations on tree diagram we composed «the genetic landscape» of area, where the description of population genetic structure is presented by equally spaced figures consistently consolidating populations according to their genetic distances from each other and thus creating a genetic landscape. This approach is not only a tool for elementary population boundary detection, but also can be effectively used for identification of borders and sizes of population as naturalistic unit.
Multigcnctic landscape is a collection of different genetic systems which arc specific to the region and ethnic groups, which have their geographical areas, their geographical, historical and cultural boundaries. Gene flows arc run through these conventional boundaries, but they arc less intense than in the limits of area. These limits arc ambiguous and fluid, but it is real. You can identify them by studying, for example, the structure of marriage migration. Therefore anthropogenesis of different populations will inevitably differ from each other. Ethnogenetic composition tends to change over time, from generation to generation, and hence there is a need to understand the structure of the genepool, not only at a given time, but also in the study of genetic processes that form and reform the gcncpooL In this regard, the studying of multigcnctic landscapes is in close contact with the demographics, medical and genetic ecology, anthropology, ethnology, archeology and history of the peoples, that is, with a range of areas, not only natural, but also the humanities knowleges.
Study of genomic diversity is important not only to address questions of origin and genetic history of different ethnic groups, but is also the basis for molecular epidemiology of hereditary and multifactor diseases. Each region is characterized by a specific set of common genetically determined diseases. To understand the causes of the prevalence of disease in different regions, and to develop approaches to their early DNA diagnosis and effective prevention, initially it is necessary to conduct population-based studies, which determine the development of the disease.
Purpose of research is to implement a comprehensive description of the structure of indigenous Central Asian populations genetic pool, examine demographic, phylogenetic and evolutionary features of Central Asian populations through the analysis of genetic variety of mtDNA, Y-chromosomal (NRY), autosomal, X-chromosomal microsatcllites and immunogcnetic variants of Helicobacter pylori (H.pylori) and hepatitis В virus (HB V).
To achieve this goal the following tasks of research is solved:
specification of immunogcnetic variants of H.pylori and HBV, allocated at the patients in Central Asian region, with the subsequent comparative phylogenetic analysis of H.pylori and HBV regional versions with those in other regions of the world;
examination of genetic variety and degree of genetic differentiation of Central Asian populations according to classical population-genetic objects -polymorphisms of mtDNA, Y-chromosomal, autosomal and X- chromosomal STRs;
assessment of the Western and East-Eurasian lines of population inheritance contribution to Central Asian populations’ genetic pool at regional, ethnic, sub-cthnic levels and in a level of elementary populations;
reviewing of character of regional populations relationships by genetic variety of mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers in view of ethnographic, social and linguistic data;
evaluation of sex-specific genetic structure and the social organization according to polymorphisms of mtDNA, autosomal, X-chromosomal, Y-chromosomal markers in the region;
determination of ancient ways of migrations and scripts of formation of Central Asian populations according to mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers and immunogcnetic variants of H.pylori and HBV',
evaluation of ethnogenetic position of studied Central Asian populations in the system of genetic pools of Eurasia and the world in general through comparative analysis of all studied population-genetic parameters.
Scientific novelty of dissertational research consists in the following:
for the first time was performed a study of genetic pool structure of 26 Central Asian populations from 6 ethnic groups as complete population systems using a wide range of genetic objects;
for the first time was made an assessment of informativeness of each type of genetic subjects. For the first time was received detailed characteristic of genetic pool structure of indigenous Central Asian population on the basis of variability lines of the spectrum of genetical objects;
for the first time was defined the ratio of Westem-and the East-Eurasian lines in a genepool of Central Asian population and were made an assessments of genetic variety level and genetic differentiation degree of regional populations as a whole;
for the first time phylogenetic analysis of major haplogroups of investigated genetic subjects was conducted;
for the first time the position of Central Asian population in population genetic pool system of surrounding regions and Eurasia in the whole was studied;
for the first time the evolutionary-adaptable mechanisms, necessary in the forecast of formations of multigenic pathologies in region were studied at 6 ethnoses of Central Asian.
CONCLUSION
1. H.pylori from Central Asian territory is similar to Western Europe isolates, and shaped by two ancestral populations genotype Ancestral Europe 1 (dominant) and Ancestral Europe2 and for AE1-genotype Central Asian region probably is the source. H.pylori from the territory of Central Asia form a separate cluster group: close relationship of Tadjik, Uzbek strains and Iranian isolates from the north of Iran is established. Kirghiz isolates were found to be closer to populations from territory of Siberia.
2. High diversity of HBV genotypes in Central Asia was found -4 genotypes (A, C, D, and G). Phylogenetic analysis of Central Asian genotype HBV-with options for other regions of the world showed a close relationship between the dominant genotype D (0,78), the D1-subtype with variants of the virus in Europe, the Middle East and Africa.
3. The rates of genetic affinity for STR-NRY in Kazakhs, Turkmens, Karakalpaks Turtkul at the level of the same lineage were high: 0,58 (p<0,001); 0,34 (p<0,01) and 0,77 (p<0,001), respectively. The coefficients of relationship at the level of clan for Kazakhs, Turkmens, Uzbeks and Karakalpaks from Kungrad and Turtkul were lower: 0,30 (r<0,01); 0,21 (p<0,001) and 0,40 (r<0,001); 0,07 (p<0,05) and 0,09 (p<0,05), respectively. At the level of the tribe, the indicators were negative for all Turkic populations: -0,02 (r<0,05);-0,04 (r<0,001);-0,07 (p<0,01); -0,0011 (r<0,1) and -0,10 (r<0,01), respectively.
4. The analysis of mtDNA HVS-1 showed that total rate of differentiation level for all populations was low: FST=0,013; p<0,0001. Level of diversity between groups was 0,6% (p<0,001) of the total variability. Parameter of genetic differences between Turkic and Indo-Iranian populations made 0,55% (p<0,0283) of the total genetic variability. The rate of genetic differentiation on a sub-ethnic level was significantly expressed in Indo-Iranian group (FST=0,0197;r<0,001) than among the Turkic-speaking (0,3%; p=0,10). In all populations, in general, wasn‟t detected the correlation between genetic and geographic distances at the global level on mtDNA HVS-1: r=0,00682; p=0,502.
5. Analysis of STR-NRY showed that the level of the genetic differentiation between ethnic groups was 5,6% (p<0,02); general differentiation between populations made RST=0,186 (p<0,001). Combined analysis, taking into account the language and way of life of Turkic and Indo Iranian populations, showed the general differences between the two groups – 9,1% Value of genetic differentiation when comparing the ethnos-ethnos was slightly lower than the level within ethnos: 5,6% among ethnic groups, 18,6%, and 13,7%-between populations within the ethnic group.
6. Analysis of heterozygosity (H) and the average number of pairwise differences (p) of mtDNA, were high in nomadic populations (av.H=0,99; av.p=5,29) and farmer populations (av.H=0,99; av.p=5,32). Heterozygosity (H) on Y- chromosome was lower in nomadic groups than in the agrarian – 0,86 and 0,99,respectively (p<0,01). Nomadic populations exhibit a higher level of population differentiation (RST) in comparison with farmers - 0,19 and 0,06, respectively (p<0,01). Indicators of population growth (r) were lower in nomadic populations compared with farmers - 1,004 and 1,008, respectively (p=0,056).
7. The level of genetic differentiation in all ethnic groups was higher on the Y chromosome in comparison with mtDNA. The farming populations showed no significant difference in the genetic differentiation FST (Y)=0,069 and FST (mtDNA)=0,034, while among patrilineal nomadic population the level of genetic diversity was higher in the male line of inheritance - FST(Y)=0,177 and FST (mtDNA)=0,010. Genetic diversity of population structure in patrilineal nomads on autosomal and X-linked markers were: FST (A)=0,008 (0,006-0,010) and FST (X)=0,011 (0,001-0,004) (H0: FST(A)=FST(X); H1: FST(A)>FST(X); p=0,02). In bilinear farmer populations the differences of autosomal and X-chromosomal markers were insignificant: FST (A)=0,014 (0,012-0,016) and FST (X)=0,013 (0,008-0,018 at p=0,36).
8. Analysis of mtDNA indicated that the age of expansion on the territory of Eurasia (τw) declined significantly from East to West (r=0,72; p<0,001). The age of expansion had a pronounced tendency to decrease from 30 thousand years in China to 17 thousand years in Western Europe. Age of expansion in Central Asia amounted to 26 thousand years. Results of expansion analysis on NRY also show a decrease in genetic diversity from the East to the West of Eurasia (r=0,49; p<0,001). In Central Asia this age was 16 thousand yrs. According STRs-NRYBatwing analysis of the minimal age of Uzbek population origin was 1232,71 yrs old (Ne=14088 (6765-23942); α=0,0108 (0,0065-0,0155)).
9. The apportionment of multilocus genetic variations among ethnic and linguistic groups of Central Asian populations showed that more than 98% of all variations were within the population (p<0,0001). Evaluation of the ethnic and linguistic affiliations in the observed variations showed reliable conformity - FST=0,007; p<0,0001 and FST=0,011; p<0,0001, respectively. We didn‟t find evidence of geographical isolation within each of the Turkic and Indo Iranian groups of populations (p=0,363 and p=0,772, respectively).
10. Analysis of multilocus allelic diversity (AR) and heterozygosity (He) showed differences among the Central Asian and other populations in allelic variety (χ2 =105,29; d.f.=25; p<0,0001) and heterozygosity (χ2=67,98; d.f.=25; p<0,0001). Population differentiation at multilocus analysis at populations of Central Asia is more pronounced than in the other regions of Eurasia: in European and Middle Eastern groups pairwise estimation of FST ranged from 0,011 to 0,015 and -0,008-0,021, respectively; in East-Asian groups from -0,011 to 0,046; and finally, in Central Asia these rates ranged from -0,004 to 0,056. Heterozygosity was significantly higher in the group of the Indo-Iranian populations than among Turkic-speaking (He=0,818 and He=0,787, respectively; Z=-4, 55; p<0,0001). According to multilocus analysis all 26 Central Asian populations slightly but significantly differed (FST=0,015; CI99%=0,011-0,018; p<0,01).
In this article, the author analyzes the work of the Buddhist monk Xuanzang, who visited the Central Asian region in the early Middle Ages, "Da Tan siyuy tzu" and other sources on the history of Central Asia, which are not equivalent with this source. This article addresses one of the most serious issues in early medieval Central Asian history. It is known that the travellers of Buddhist monks who visited the Central Asian region in the early Middle Ages, the information contained in them, are not yet available in Arabic-Persian sources and cover a relatively dark period, and the article fills this gap. Among them, Xuanzang's "Da Tan siyu tzu" stands out. Therefore, this article serves as additional material to the work published so far.
The article provides information on the density, specific gravity and porosity of irrigated light serozem soils in the Central region – Syrdarya and Samarkand oasis and the Southern region – Surkhandarya valley. The «pile heel» formed in the subsoil of these soils - the compacted layer every 3-4 years, at the end of the growing season – once in the autumn to carry out deep loosening, to improve not only the general physical, water-physical and physicomechanical properties of the soil, rather, it has a more positive effect on plant growth and development.
В данной статье предусматриваетсяпроисхождение и распространение каракульских овец в республике Каракалпакии. А также характеристика климату и растительного покрову этого региона. Дается заключения в процесс породообразования, многовековым селекционным работам создателей породы – народов Средней Азии. Сделаны выводы о происхождения каракульских овец и распространения каракалпакского сура в регионах Каракалпакии.
Each region of the Fergana Valley is characterized by its strong management centers, the diversity of natural resources, the general agro-climatic factors, the availability and the potential for the creation of a finished product production system. For this reason, it is advisable to work out prospective directions for the deployment and development of productive forces. At the same time, it is important to fully utilize the capabilities of the main sector in the organized economic system of the region. The future development of productive forces in this area is inseparably linked with agro-industrial production and its sectoral and regional improvement. In addition, the interregional production system, which is based on the continuous growth of food production in the regions, the intensification of intersectoral communications, the expansion of the role of intensive factors, in turn, will increase the demand for complex scientific forecasts. At this stage, the scientific forecasting should reflect the activities of the food market and facilitate the expansion of foreign markets. The region's participation in the world economy opens the way for further stages of social and economic development. At the same time, the emphasis should be on the sustainable improvement of the elastic business structure, adapted to the changing competition inherent to the market economy. The main task of the food market in the Ferghana Valley in the near and long-term perspective is to increase production efficiency and bring the level of material welfare of the population to the world's leading countries on the basis of equalizing social and economic development in the regions. This, in its turn, is a very complex and urgent issue, not only with the radical changes in the economy, but also with a change in the lives of the whole society and, consequently, the acceleration of its development. In this regard, this article elaborates the forecasts of the food market in the Ferghana Valley
for 2020-2030 and its alternative scenarios. The first scenario is based on a retrospective analysis of food production in the Ferghana Valley. In the second scenario, the population's food supply is calculated based on the minimum consumer budget, while the third scenario provides the regions' food supply coefficients and supply estimates. On the basis of the analysis of the forecast parameters of the Ferghana Valley Food Market and its results, scientific-practical conclusions have been developed.
The article discusses interdisciplinary Russian-Central Asian relations with a focus on its economic component. The specifics of the ongoing research, which is the basis for the article, is an attempt to systematically evaluate the key elements of interaction between Russia and Central Asian countries in the areas of politics, security, the economy (including in the energy sector), as well as in the social sphere. Through this lens, the most important factors and stages of relations in the period of 1991-2018 are also identified, and statistics not previously combined in one material are provided. Over the past years, since the declaration of independence of the Central Asian countries, economic relations between the Russian Federation and the regional countries have been characterized by a series of "ups" and "downs". A noticeable activation of Russian business and the overall economic policy of the Russian Federation in Central Asia began to be observed from the beginning of the 2000s. Russia's strategic interests have touched the oil and gas sector, where the vast majority of Russian investments have been represented. In recent years, in the face of continuing Western sanctions, the Central Asian region has become one of the most important, and non-alternative, economic regions for Russia. At present, new trends are beginning to intensify and deepen economic cooperation, including diversification of ties across sectors of the economy, expanding geography and improving the quality of cooperation. Investments from the Central Asian countries themselves in the Russian Federation have played and continue to play an important role in the development of economic relations. Moreover, relations between Russia and Central Asian countries in the labor migration segment have been developing dynamically and on a large scale for many years. In general, the importance of labor migration is high not only for the Russian Federation, but also for the Central Asian countries themselves. It is concluded that in recent years, Russian-Central Asian relations have been characterized by rather high dynamics. There is no doubt that the development of interaction is largely favored by traditionally close bilateral and multilateral ties: due to historical commonality, geographical proximity, socio-cultural and other proximity, the presence of institutional formats, and mutual desire for cooperation.
In this article, the conceptual and doctrinal foundations of the ideas of non-use of force and ensuring peace in the foreign policy of Uzbekistan are investigated in chronological order. The foreign policy of Uzbekistan is, first of all, a course aimed at ensuring vital tasks, primarily for the state and society. Uzbekistan's foreign policy strategy is primarily aimed at ensuring integration into the world community. The deepening of the country's integration into the world community in the current difficult conditions of international relations is an important task facing the foreign policy of Uzbekistan. The conceptual idea of foreign policy and foreign policy of the Republic of Uzbekistan is the indivisibility of security and joint and partnership actions to ensure it. The problem of national and regional security occupies an important place in Uzbekistan's foreign policy. One of the main tasks in the foreign policy of Uzbekistan was the formation of a system of regional security, which is necessary both for the republics of Central Asia and for the vast geographical area bordering the region. Another advanced idea for Uzbekistan's foreign policy is the postulate that the problems of the Central Asian region should be solved without the intervention of external forces and only by the countries of the region. Given all this, the cornerstone of Uzbekistan's foreign policy remains the non-use of force and the threat of force, and the maintenance and observance of peace. The article examines the changes occurring in the foreign policy of Uzbekistan, their regulatory consolidation, guidelines for the short, medium and long-term perspective, and on the basis of this, a number of scientific conclusions and practical recommendations are given.
The article examines the problem of centralization and decentralization of the budget. Budget decentralization is interconnected with the processes of geographical decentralization and decentralization of the system of administrative decision-making. Decentralization of the system of making and executing administrative decisions implies a wider delegation of authority to local divisions of the central executive authority. The article also states that the main goal of decentralization is to create a closer relationship between the control system and the population, and this requires strengthening the financial system of local governments. The task of decentralization is to provide the regions and local governments with certain powers in the field of taxation and expenditure of funds, as well as the ability to independently determine the parameters and structure of the budget expenditures. The article substantiates the advantages and disadvantages of budget centralization. Attempts were made to cover all arguments for and against decentralization.
ХХ асрнинг 20-йилларида Ўрта Осиё халқлари ҳаётида содир бўлган сиёсий ўзгаришлар бу ҳудудда мажбуран миллий-ҳудудий чегараланишнинг ўтказилиши, бунинг ҳисобига бир неча миллий республикаларнинг, жумладан, Ўзбекистон ССРнинг ташкил этилиши туб ерли аҳолининг сиёсий, ижтимоий, иқтисодий ҳуқуқларининг чекланишини янада кучайтирди, уларни миллий, маънавий, диний соҳалардаги эркинликларидан мосуво қилиш авж олди. Маҳаллий кадрлар техник қолоқликда, саводсизликда айбланиб, марказдан маҳаллий шарт-шароитни, туб ерли аҳолининг тили, урф-одатларини билмайдиган, тушунмайдиган европалик кадрлар оқимининг кириб келиши ортиб борди.
Developing the idea of the Arab world or region, Egyptian researchers R. Al-Bustani and F. Fargus, analyzing regional processes, starting with the formation of modern states, do not use the term Middle East, but they write about the Arab world, Arab states, North Africa, East Africa , "The Fertile Crescent" as a part of Iraq, Syria, Lebanon, Israel, Palestine, the Arabian Peninsula. Another Egyptian scholar, M. Muallim, notes that the Middle East is a region from Iran in the east to Libya in the west, and from Turkey in the north to the southern borders of the Arabian Peninsula and in Africa to the southern borders of Sudan. Such a Middle East is a political concept, and, in his opinion, it is better to use the term “Asian-African region”, which includes all the specifics of territories, starting with the geographical location at the junction of Europe, Asia, Africa, and ending with energy resources. Some scientists compare the excesses of the “Arab spring” and its consequences with such powerful historical disasters as the collapse of the Ottoman Empire and the emergence of national Arab entities after the First World War. In the current situation, the diplomacy of Uzbekistan should assist in resolving conflicts and positive political and economic transformation of the Middle East and have a solid analytical foundation. The article pursues a study of the situation in the Middle East in the light of the changes in regimes and changes in the geopolitical configuration of the region. The article also analyzes the features of the formation and implementation of the foreign policy of the Islamic Republic of Iran (IRI) in the Middle East (Iraq, Turkey, the Syrian-Lebanese-Palestinian zone, Egypt, the Persian Gulf countries, Yemen) in the context of the transformation of forms and methods of implementing Washington’s strategy on “systemic containment” Iran. Particular attention is paid to identifying the potential of Iran as one of the leaders in the Middle East region. Therefore, the article widely discusses the main directions of the foreign policy of the countries of the Middle East and gives us assessments of the Middle East situation.
Вступлением человечества в новую стадию развития цивилизации, которое обострило проблемы его выживания. Это связано с рядом глобальных проблем, порожденных современностью или унаследованных от прошлого. По своему характеру глобальные проблемы современности различны: от угрозы ядерной войны, экологической катастрофы и до различных эпидемии. От растущего раскола мира на «богатые» и «бедные» страны до перспективы истощения традиционных и необходимости поиска новых источников энергии.