The purpose of the study was to determine and evaluate the features of morphological changes in the liver parenchyma of 5-month-old white outbred rats under the influence of anti inflammatory drugs under conditions of polypharmacy.
The object of study for experimental studies was taken 250 white male rats weighing 200-250 g.
The scientific novelty of the research is as follows: polypharmacy of anti-inflammatory drugs negatively affects all parameters of liver structures. Under the influence of polypharmacy, there is a decrease in the absolute mass of the liver, volume and morphological parameters of the liver parenchyma. The decrease in morphometric parameters depends on the number of drugs in polypharmacy; under conditions of polypharmacy, the state of the hepatic capillaries and internal bile ducts, as well as biological membranes, was studied, as a result of which the structural structure of the liver, the development of destruction of the hepatic tissue were studied, and the morphofunctional foundations of this condition were shown.
Implementation of the research results. Based on the obtained scientific results, the morphofunctional characteristics of the liver of rats in the norm and under the influence of polypharmacy were determined:
Approved methodological recommendations: "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Conclusion No. 8n-r / 265 dated 14.03.2022 of the Ministry of Health of the Republic of Uzbekistan) and "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Uzbekistan, Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z 180 of 2022), electronic program No. DGU 1038 "Program for studying the comparative characteristics of morphological changes caused by polypharmacy in the liver."
The scientific results obtained in the study of morphological and functional properties and morphometric changes in the structure of the liver under the influence of polypharmacy have been introduced into the practice of the Samarkand branch of the Republican Specialized Oncological and Radiological Scientific and Practical Medical Center of the Samarkand City Medical Association (Order of the Ministry of Health of the Republic of Uzbekistan dated March 14, 2022, 8n-r / 265-No. and conclusion No. 8 n-z 180 of 2022). The implementation of the obtained research data allows developing methods for early diagnosis, treatment and prediction of organopathology by morphological parameters, improving the quality of life and reducing the number of complications.
The structure and scope of the dissertation. The structure of the dissertation consists of an introduction, three chapters, a conclusion and a list of references. The volume of the dissertation was 103 pages.
Topicality and demand of the subject of dissertation. Researches of human population genomic variety and scenarios of its genetic pool formation arc one of perspective directions of modem genetics. Prompt progress in this field has allowed defining the basic routes of continents settlement. However the information about Central Asian (CA) populations even on «classical» genetic markers has accidental, fragmentary character, and requires additional large-scale investigations. Besides, according to historical, archeological, paleontological and some anthropogenetic studies, given region was playing certain role in ancient moving of modem human ancestors throughout Eurasian continent. Therefore it is extremely important to summarize and perform complex assessment of new and collected data on Central Asian populations as practically there arc no multivariate analyses studies of given region as a complex population system.
In studies of human population genetic structure arc usually used various approaches allowing understanding concept of populations subdivision and character of genetic relationships between them. Among these techniques the prominent place belongs to approaches based on an assessment of genetic distances between populations with their subsequent analysis by multivariate statistics methods. For even more compelling picture of the relationships between the populations on tree diagram we composed «the genetic landscape» of area, where the description of population genetic structure is presented by equally spaced figures consistently consolidating populations according to their genetic distances from each other and thus creating a genetic landscape. This approach is not only a tool for elementary population boundary detection, but also can be effectively used for identification of borders and sizes of population as naturalistic unit.
Multigcnctic landscape is a collection of different genetic systems which arc specific to the region and ethnic groups, which have their geographical areas, their geographical, historical and cultural boundaries. Gene flows arc run through these conventional boundaries, but they arc less intense than in the limits of area. These limits arc ambiguous and fluid, but it is real. You can identify them by studying, for example, the structure of marriage migration. Therefore anthropogenesis of different populations will inevitably differ from each other. Ethnogenetic composition tends to change over time, from generation to generation, and hence there is a need to understand the structure of the genepool, not only at a given time, but also in the study of genetic processes that form and reform the gcncpooL In this regard, the studying of multigcnctic landscapes is in close contact with the demographics, medical and genetic ecology, anthropology, ethnology, archeology and history of the peoples, that is, with a range of areas, not only natural, but also the humanities knowleges.
Study of genomic diversity is important not only to address questions of origin and genetic history of different ethnic groups, but is also the basis for molecular epidemiology of hereditary and multifactor diseases. Each region is characterized by a specific set of common genetically determined diseases. To understand the causes of the prevalence of disease in different regions, and to develop approaches to their early DNA diagnosis and effective prevention, initially it is necessary to conduct population-based studies, which determine the development of the disease.
Purpose of research is to implement a comprehensive description of the structure of indigenous Central Asian populations genetic pool, examine demographic, phylogenetic and evolutionary features of Central Asian populations through the analysis of genetic variety of mtDNA, Y-chromosomal (NRY), autosomal, X-chromosomal microsatcllites and immunogcnetic variants of Helicobacter pylori (H.pylori) and hepatitis В virus (HB V).
To achieve this goal the following tasks of research is solved:
specification of immunogcnetic variants of H.pylori and HBV, allocated at the patients in Central Asian region, with the subsequent comparative phylogenetic analysis of H.pylori and HBV regional versions with those in other regions of the world;
examination of genetic variety and degree of genetic differentiation of Central Asian populations according to classical population-genetic objects -polymorphisms of mtDNA, Y-chromosomal, autosomal and X- chromosomal STRs;
assessment of the Western and East-Eurasian lines of population inheritance contribution to Central Asian populations’ genetic pool at regional, ethnic, sub-cthnic levels and in a level of elementary populations;
reviewing of character of regional populations relationships by genetic variety of mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers in view of ethnographic, social and linguistic data;
evaluation of sex-specific genetic structure and the social organization according to polymorphisms of mtDNA, autosomal, X-chromosomal, Y-chromosomal markers in the region;
determination of ancient ways of migrations and scripts of formation of Central Asian populations according to mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers and immunogcnetic variants of H.pylori and HBV',
evaluation of ethnogenetic position of studied Central Asian populations in the system of genetic pools of Eurasia and the world in general through comparative analysis of all studied population-genetic parameters.
Scientific novelty of dissertational research consists in the following:
for the first time was performed a study of genetic pool structure of 26 Central Asian populations from 6 ethnic groups as complete population systems using a wide range of genetic objects;
for the first time was made an assessment of informativeness of each type of genetic subjects. For the first time was received detailed characteristic of genetic pool structure of indigenous Central Asian population on the basis of variability lines of the spectrum of genetical objects;
for the first time was defined the ratio of Westem-and the East-Eurasian lines in a genepool of Central Asian population and were made an assessments of genetic variety level and genetic differentiation degree of regional populations as a whole;
for the first time phylogenetic analysis of major haplogroups of investigated genetic subjects was conducted;
for the first time the position of Central Asian population in population genetic pool system of surrounding regions and Eurasia in the whole was studied;
for the first time the evolutionary-adaptable mechanisms, necessary in the forecast of formations of multigenic pathologies in region were studied at 6 ethnoses of Central Asian.
CONCLUSION
1. H.pylori from Central Asian territory is similar to Western Europe isolates, and shaped by two ancestral populations genotype Ancestral Europe 1 (dominant) and Ancestral Europe2 and for AE1-genotype Central Asian region probably is the source. H.pylori from the territory of Central Asia form a separate cluster group: close relationship of Tadjik, Uzbek strains and Iranian isolates from the north of Iran is established. Kirghiz isolates were found to be closer to populations from territory of Siberia.
2. High diversity of HBV genotypes in Central Asia was found -4 genotypes (A, C, D, and G). Phylogenetic analysis of Central Asian genotype HBV-with options for other regions of the world showed a close relationship between the dominant genotype D (0,78), the D1-subtype with variants of the virus in Europe, the Middle East and Africa.
3. The rates of genetic affinity for STR-NRY in Kazakhs, Turkmens, Karakalpaks Turtkul at the level of the same lineage were high: 0,58 (p<0,001); 0,34 (p<0,01) and 0,77 (p<0,001), respectively. The coefficients of relationship at the level of clan for Kazakhs, Turkmens, Uzbeks and Karakalpaks from Kungrad and Turtkul were lower: 0,30 (r<0,01); 0,21 (p<0,001) and 0,40 (r<0,001); 0,07 (p<0,05) and 0,09 (p<0,05), respectively. At the level of the tribe, the indicators were negative for all Turkic populations: -0,02 (r<0,05);-0,04 (r<0,001);-0,07 (p<0,01); -0,0011 (r<0,1) and -0,10 (r<0,01), respectively.
4. The analysis of mtDNA HVS-1 showed that total rate of differentiation level for all populations was low: FST=0,013; p<0,0001. Level of diversity between groups was 0,6% (p<0,001) of the total variability. Parameter of genetic differences between Turkic and Indo-Iranian populations made 0,55% (p<0,0283) of the total genetic variability. The rate of genetic differentiation on a sub-ethnic level was significantly expressed in Indo-Iranian group (FST=0,0197;r<0,001) than among the Turkic-speaking (0,3%; p=0,10). In all populations, in general, wasn‟t detected the correlation between genetic and geographic distances at the global level on mtDNA HVS-1: r=0,00682; p=0,502.
5. Analysis of STR-NRY showed that the level of the genetic differentiation between ethnic groups was 5,6% (p<0,02); general differentiation between populations made RST=0,186 (p<0,001). Combined analysis, taking into account the language and way of life of Turkic and Indo Iranian populations, showed the general differences between the two groups – 9,1% Value of genetic differentiation when comparing the ethnos-ethnos was slightly lower than the level within ethnos: 5,6% among ethnic groups, 18,6%, and 13,7%-between populations within the ethnic group.
6. Analysis of heterozygosity (H) and the average number of pairwise differences (p) of mtDNA, were high in nomadic populations (av.H=0,99; av.p=5,29) and farmer populations (av.H=0,99; av.p=5,32). Heterozygosity (H) on Y- chromosome was lower in nomadic groups than in the agrarian – 0,86 and 0,99,respectively (p<0,01). Nomadic populations exhibit a higher level of population differentiation (RST) in comparison with farmers - 0,19 and 0,06, respectively (p<0,01). Indicators of population growth (r) were lower in nomadic populations compared with farmers - 1,004 and 1,008, respectively (p=0,056).
7. The level of genetic differentiation in all ethnic groups was higher on the Y chromosome in comparison with mtDNA. The farming populations showed no significant difference in the genetic differentiation FST (Y)=0,069 and FST (mtDNA)=0,034, while among patrilineal nomadic population the level of genetic diversity was higher in the male line of inheritance - FST(Y)=0,177 and FST (mtDNA)=0,010. Genetic diversity of population structure in patrilineal nomads on autosomal and X-linked markers were: FST (A)=0,008 (0,006-0,010) and FST (X)=0,011 (0,001-0,004) (H0: FST(A)=FST(X); H1: FST(A)>FST(X); p=0,02). In bilinear farmer populations the differences of autosomal and X-chromosomal markers were insignificant: FST (A)=0,014 (0,012-0,016) and FST (X)=0,013 (0,008-0,018 at p=0,36).
8. Analysis of mtDNA indicated that the age of expansion on the territory of Eurasia (τw) declined significantly from East to West (r=0,72; p<0,001). The age of expansion had a pronounced tendency to decrease from 30 thousand years in China to 17 thousand years in Western Europe. Age of expansion in Central Asia amounted to 26 thousand years. Results of expansion analysis on NRY also show a decrease in genetic diversity from the East to the West of Eurasia (r=0,49; p<0,001). In Central Asia this age was 16 thousand yrs. According STRs-NRYBatwing analysis of the minimal age of Uzbek population origin was 1232,71 yrs old (Ne=14088 (6765-23942); α=0,0108 (0,0065-0,0155)).
9. The apportionment of multilocus genetic variations among ethnic and linguistic groups of Central Asian populations showed that more than 98% of all variations were within the population (p<0,0001). Evaluation of the ethnic and linguistic affiliations in the observed variations showed reliable conformity - FST=0,007; p<0,0001 and FST=0,011; p<0,0001, respectively. We didn‟t find evidence of geographical isolation within each of the Turkic and Indo Iranian groups of populations (p=0,363 and p=0,772, respectively).
10. Analysis of multilocus allelic diversity (AR) and heterozygosity (He) showed differences among the Central Asian and other populations in allelic variety (χ2 =105,29; d.f.=25; p<0,0001) and heterozygosity (χ2=67,98; d.f.=25; p<0,0001). Population differentiation at multilocus analysis at populations of Central Asia is more pronounced than in the other regions of Eurasia: in European and Middle Eastern groups pairwise estimation of FST ranged from 0,011 to 0,015 and -0,008-0,021, respectively; in East-Asian groups from -0,011 to 0,046; and finally, in Central Asia these rates ranged from -0,004 to 0,056. Heterozygosity was significantly higher in the group of the Indo-Iranian populations than among Turkic-speaking (He=0,818 and He=0,787, respectively; Z=-4, 55; p<0,0001). According to multilocus analysis all 26 Central Asian populations slightly but significantly differed (FST=0,015; CI99%=0,011-0,018; p<0,01).
This article explores the deep philosophical content of the "Persian Letters" by Charles Louis Montesquieu, one of the first representatives of the French Enlightenment, in which the Persian view allows a two-sided approach, which means that the reflection of the realities of the French is uniquely repeated in the Persians.Montesquieu's Persian view of the political system in which a person lives, and vice versa, remote observation of society's attitude towards a person is analyzed through the genre of a parable, decentralized
observation, characteristic view, humorous critical views. The article deals with the problem of cultural barriers as a communicative activity of
representatives of two different cultural associations, emphasizing the importance of cultural factors in the translation process and the translation of cultures, not languages, according to the cultural and ethnographic concept of translation. In the text of the translation, the
specificity of the interaction of language and culture is reflected in the diversity of the “worldview”. One of the main criteria for literary translation is the preservation of the individual style of the author of the work. From the point of view of translation standards, it is natural that the translator has difficulty in understanding a fragment of a literary text. From this point of view, it is difficult to achieve an adequate translation without a reflective understanding of the content of the original in the translation of a philosophical work that differs in style and period of writing. The importance of observing the functional and
methodological norms of the content of the text in order to achieve the adequacy of the stylistic figures used in the work to the target language is investigated.
In the world, attention is drawn to the great importance of the period of early postnatal ontogenesis for the morphofunctional differentiation of organs and systems of the future organism, since a violation of their formation in ontogenesis is a possible reason for the development of various congenital pathologies. Our experimental studies show that by the time of birth in rabbits, the main structural components of the jejunal wall have been formed, however, in their morphometric parameters and morphological picture, they differ significantly from the jejunum of adults. The jejunum of 10 day old rabbits has morphometric and structural differences from the jejunum of newborn rabbits. The total wall thickness increases significantly, mainly due to the mucous and submucosal membranes, the villi and crypts begin to lure in shape
In the introductory part of the article the concept of the legal person of foreign countries is analyzed. In the basic part the questions of definition of nationality of foreign legal person and its value are considered. In the conclusion the author highlights the importance of definition of a nationality of the foreign legal person both at the international level and for the separate countries.
The article deals with one of the rare surgical diseases – gallstone intestinal obstruction. In the etiology play a "large" gallstones and internal biliary-enteric fistulas. The clinic and diagnosis of this pathology may not differ from other types of intestinal obstruction, but the treatment tactics of biliary ileus has several features and requires special surgical tactics.
An adverb is a lexico-grammatical class of unchangeable, as a rule, words denoting a sign of an action, quality or object and acting in the syntactic function of a circumstance or definition, less often of a predicate. The adverb in all languages of the world belongs to the late parts of speech, the formation process of which continues to the present day. At the same time, words belonging to this category still retain their functions in other parts of speech from which they were formed. Another distinctive feature of the adverb is the conceptual heterogeneity of the class of words in comparison with other parts of speech. Based on the above, we can say that there are many definitions of adverbs in Afghan and Iranian studies. Previously, the works of Arab scholars served as the basis for studying the grammar of Dari and the Persian languages; today, Afghan and Iranian philologists admit that there are significant differences between Arabic and their languages, and therefore, in studying the grammar of their language, they try to take into account the grammatical features exclusively Farsi. It should be noted that there is an activity of Iranian philologists in the field of writing scientific articles and books devoted to the interpretation of a particular grammatical issue, the attention of researchers to the structure of syntax has increased. We have analyzed a number of works on the grammar of the Dari and Persian languages, which touch on the question of parts of speech and minor members of a sentence. Below is a brief description of some works on the grammar of the modern Dari and Persian languages, in which the question of our research is most fully considered. In world linguistics, the Dari language is not widely studied, like the Persian language. In Iranian studies, in the scientific description of this language, it is mainly noted that it differs from the modern Persian language. In the Dari language, as well as in the Persian language, the authors consider the adverb from a morphological and syntactic point of view. In the course of our research, we analyzed the works related to the modern Dari language, as well as unique works that are being republished for the second time in Afghanistan
The paper considers interlayer shifts of combined two-layer cylindrical shells made of composite layers differing in thickness and physical and mechanical properties, and also investigates the effect of stress-strain state of such shells on their strength and deformability.
Recent translation studies include the reader, the system, the situation, the viewpoint of the target text and place them in the field of view. Nowadays not only a one-way translation tendency is used but in order to pay attention to the target text the direct translation research offers a new tendency of reexamination of the translation concept by the diversification. Sometimes when reading the target text one can feel insufficient like if something is missing there. For instance, a reader can notice that the target text does not include some important parts or the feelings while reading the original and the target text are different. The difference between the source text and the target text depends on the difference between cultures (countries, languages). Deviation of the translation is to be seen in both directions. The famous translator Anthony Pym (2010) says that the main purpose of any translation is communication. A good translator should not merely follow the source text since it is important for the reader to understand both texts. In other words, Pym shows a new direction to the translator. Intercultural difference can be a good starting point for a new text, a new language conception, new life. Translation must not be just equivalent to the source text. It also cannot ignore the difference between languages. Translation should give the knowledge of mistakes and help to avoid them. Language act during the translation is born through the translator’s prism and includes his knowledge for interpreting. That helps the translator to create a new text. This work devoted to the role of the author and the translator in the creation of a new text through interpretation. The author of this work stresses the translation of the memorial plate of the Navoi Theater into three languages: Uzbek, English, Japanese.
In the past, the way of life of Arabs influenced their attitude to creativity. The use of various aphorisms was considered commonplace in Arab life. Since they were eloquent and prone to literature, they could quickly and easily use different proverbs and sayings or express their thoughts through beautiful poems, puzzles or beautiful instructions. The literary atmosphere of the time, the organization of annual conferences and the large number of applicants for participation in these conferences also contributed to this. Due to the large number of applicants, the competition has traditionally been held for twenty days. The development of sayings and proverbs in the history of Arabic literature dates back to the time of jahiliya. During this period, proverbs were used orally. Until the eighth century, there was no written copy, and later from scientific data it became known that the first book on this subject belongs to Mufazzal al-Dabbi. This article gives an overview of the notion of proverbs and sayings, and the differences between them. The central question of the article is the proverbs that are presented from the verses of the Qur'an and the hadiths of the Prophet, as well as some historical events in Arabic life.
In this chapter, the reader gets to know why everything is about computer networks. Computer networks vary in transmission media (wired or wireless), topology, size and scale. They can be classified as enabled or disabled. They can also be divided into local networks, metropolitan networks and global networks. This chapter lists common computer networking applications. A router is a device that connects two or more packet networks or subnets. It performs two main functions: it monitors traffic between these networks by routing data packets to the intended IP addresses, and allows multiple devices to use the same Internet connection
In the introductory part of the article the author gives concept to social segment of information infrastructure and considers it as object of law. In the basic part of the article the author considers possible threats to the safety of activity of social segment of the information infrastructure. In the conclusion the author makes offers on realization of safety of activity of social segment of the information infrastructure.
Purpose of the study: to study the effect of the combination of valsartan and sacubitril on the indices of central hemodynamics in patients with coronary heart disease (CHD) within 2 years after revascularization. Material and research methods. The study included 320 patients with coronary artery disease who underwent coronary revascularization. All patients were divided into 2 groups: patients who received valsartan (group B, 160 people), patients who received ARNI - a combination of valsartan and sacubitrile molecules (group C, 160 people). At baseline and in dynamics after three months, at the end of the first and second years of follow-up after revascularization in patients with coronary artery disease systolic the blood pressure (SBP, mm Hg), diastolic blood pressure (DBP, mm Hg), heart rate in minute, the concentration of brain natriuretic peptide (BNP) in the blood were determined. Also, during echocardiography, the stroke volume of the heart, indexed to the body surface area (SI, ml / m2), the minute index (MI, ml / m2), the mean pressure in the pulmonary artery (PA, mm Hg) were determined. Research results. In the group of patients taking valsartan (group B), the relative dynamics of BNP concentration was -10.69 ± 0.55% by the 3rd month of observation, -21.24 ± 1.03% by the end of the 1st year, and -34, 39 ± 1.64% by the end of the 2nd year of observation. The inclusion of sacubitril in the therapy scheme contributed to a greater positive effect in reducing the BNP concentration: the relative dynamics of the BNP concentration was -10.30 ± 0.52% by the 3rd month of observation, - 21.91 ± 1.00% by the end of the first year of observation, and -39.28 ± 1.67% (p <0.05 significant difference with group B). By the end of the 1st and 2nd years of observation, the use of a combination of valsartan and sacubitril contributed to a more pronounced decrease in blood pressure (p <0.01), a more pronounced dynamics of MI (p <0.05) and a decrease in pressure in РA (significantly lower baseline indicators, p <0.05 and indicator in group B, p <0.01). Conclusion. The present study revealed a positive effect of revascularization and subsequent therapy of coronary artery disease with the inclusion of sacubitrile on the BNP concentration, blood pressure and mean pressure of pulmonary artery.
The tax burden indicator plays an important role in ensuring the economic stability of the country and determines the place of taxes in the economic life of the society. In most countries, in the analysis of the level of the current tax burden, the assessment methodology is widely used by the ratio of state budget revenues to GDP. It represents the tax burden at the macroeconomic level and may differ slightly from its level in some entities.