The aim of the study is to development of an algorithm for managing pregnancy and childbirth by studying the functional state of the mother-placenta-fetus system in pregnant women who have undergone COVID-19 in different trimesters of pregnancy.
The object of the study was 105 pregnant women who, were treated at the Samarkand Regional Perinatal Center and a specialized maternity center for pregnant women with COVID-19
Тhe scientific novelty of the research consists of the followings: for the first time in pregnant women infected with COVID-19, a relationship was established between the course of pregnancy, childbirth, the postpartum period and the development of complications depending on the trimester and severity of the disease; a direct correlation has been established between the state of the vessels of the mother-placenta-fetus system (resistance and pulsation indices, Endothelin-1 indicators), disorders in the hemostasis system (D-dimer, platelet aggregation) and the clinical course of the disease in pregnant women who underwent COVID-19; it has been established for the first time that the developed scale for assessing risk factors for non-developing pregnancy in women infected with COVID-19 (age, BMI, obstetric history, gestation period, hemostasis system status, endothelial function and severity of the disease) can serve as a prognostic marker of the degree of risk of pregnancy complications; it was proved for the first time that the choice of effective therapy for restoring hemodynamics in the mother-placenta-fetus system, in women who underwent COVID-19 at different stages of pregnancy, leads to a decrease in the number of thrombophilic complications.
Implementation of the research results. The results of the scientific research were introduced into the practical activities of the Samarkand Regional Perinatal Center by Order No. 128/1 of 01.09.2022 and the Samarkand City Maternity Complex No. 1 by order No. 58/1 of 03.10.2022. In pregnant women who underwent COVID-19 at different periods of pregnancy, changes in the mother-placenta-fetus system were determined using simple and effective research methods, such as ultrasound and Dopplerography, and this saved 53,000 soums; obstetricians and gynecologists, as well as neonatologists and therapists, are needed to diagnose signs of complications in the echocartin, that is, it has been proven that there is no need for other highly qualified specialists for this, due to the lack of need to train new personnel, state budget funds have been saved. With early detection of disorders in the hemostasis system in pregnant women with COVID-19: the period of stay of patients in the hospital was reduced from 10.5 days to 7.5 days and the number of hospital bed days was reduced; due to the reduction of the period of stay in the hospital for several days, the number of necessary drugs was reduced (on average, drugs are used for 1 day in the amount of 130,000 soums). Examination of pregnant women infected with viral diseases using simple and effective research methods such as ultrasound and Dopplerography served to save 85,000 soums: in the early stages up to 16 (10-11 weeks. - fetometry), 19-21, 32-34, 38-40 weeks of pregnancy; due to the absence of the need to use other research methods, it was possible to reduce costs by 23.5%; early detection of changes in the hemostasis system and endothelial dysfunction using fast, budgetary and effective research methods, contributed to the prevention of possible pregnancy complications, as well as the absence of the need to use long-term and expensive research methods, and this saved 106 000 soums: the coagulogram was checked in 105 (100%) patients, time was saved and efficiency was increased; endothelin-1 was also determined in 105 (100%) patients, efficiency was increased by 78.6%.
Improving the functionality of blood circulation in the uteroplacental and fetal-placental systems, a comprehensive analysis of possible complications during pregnancy and childbirth in women who have had viral infections, improving diagnostic, preventive and prognostic measures for managing pregnancy and childbirth contributed to the birth of live, full-term and healthy newborns in women who experienced COVID-19 during pregnancy, as well as a decrease in maternal mortality and perinatal mortality, 43% of women underwent rehabilitation in the postpartum period, 23.8% of women who underwent severe COVID-19 improved their quality of life.
To introduce scientific novelty on the topic “The impact of COVID-19 on the state of hemodynamics in the mother-placenta-fetus system in pregnant women”, a letter was sent to the Ministry of Health from Samarkand State Medical University on November 9, 2022 under No. 4295 (Conclusion of the Ministry of Health No. 8 n-z / 679 of December 15, 2022).
The structure and volume of the dissertation. The content of the dissertation consists of an introduction, five chapters, conclusion, list of used references. The volume of the dissertation consists of 113 pages.
The article deals with the norms of responsibility for breaking the rules of passport system in administrative legislation of the Republic of Uzbekistan. The author elaborated scientifically grounded proposals on perfection of responsibility for breaking the rules of passport system.
In this article, the author, based on an analysis of a number of sources, tried to reveal the features of the education system of the Iranian state, which has its own history of development in the region, its historical stages and features. The author tried to objectively analyze the reforms and modernization work carried out at different periods in the education system of Iran, mainly using foreign sources. The 1979 revolution plays a very important role in the life of the Iranian state. Therefore, the article compares the education system for two periods: pre-revolutionary and post-revolutionary periods. An attempt was made to identify and show the results obtained using various tables. The education system was divided into preschool, secondary, vocational and postgraduate degrees. The reforms carried out at each stage were briefly, but substantively covered. Conclusions were made by analyzing the results of the reforms. The features of the education system in Iran were identified and the prospects for their use in the context of Uzbekistan were examined. With an emphasis on gender processes in the education system, the strengths and weaknesses of the two-tier school system were identified. Efforts were made to explain the post-revolutionary changes in the country, the Islamization of the education system and its impact on the quality of education. In conclusion, the results obtained as a result of the analysis were systematized and sorted. Suggestions were made about what aspects of the Iranian education system can be implemented in practice and in the education system of Uzbekistan. When writing an article, the author sought to develop and substantiate his conclusions using methods such as comparative analysis and the use of statistical data.
Долзарблиги. Бронх-упка тизими мальформацияларининг ягона таснифи, уларнинг номланиши, эрта ташхислаш алгоритмы, операцияга курсатмалар, унинг усули, хажми ва вақти хақидаги фикрлар хозиргача куплаб мунозарага сабаб булмоқда.
Тадқиқот мақсади: бронх-упка тизими малформацияларида операцияга курсатмалар, операция усули ва уларнинг натижаларини тахдил қилиш.
Матсриаллар ва усуллар. Бронх-упка тизими мальформациялари ташхиси билан 14 кунликдан 18 ёшгача булган 116 нафар бемор текширилиб даволанди. Ушбу патологияга биз қуйидаги нозологии атамаларни жамлаштирдик: тугма упка мальформациялари, упка гипоплазиясининг оддий ва кистоз шакллари, дизонтогенетик бронхоэктазия, упка гипоплазиясининг диафрагмал чурра билан кушилиб келиши ва упка лобар эмфиземаси. Шулардан 52 нафари уғил болалар, 64 нафарини қизлар ташкил қилди.
The purpose of the study was to determine and evaluate the features of morphological changes in the liver parenchyma of 5-month-old white outbred rats under the influence of anti inflammatory drugs under conditions of polypharmacy.
The object of study for experimental studies was taken 250 white male rats weighing 200-250 g.
The scientific novelty of the research is as follows: polypharmacy of anti-inflammatory drugs negatively affects all parameters of liver structures. Under the influence of polypharmacy, there is a decrease in the absolute mass of the liver, volume and morphological parameters of the liver parenchyma. The decrease in morphometric parameters depends on the number of drugs in polypharmacy; under conditions of polypharmacy, the state of the hepatic capillaries and internal bile ducts, as well as biological membranes, was studied, as a result of which the structural structure of the liver, the development of destruction of the hepatic tissue were studied, and the morphofunctional foundations of this condition were shown.
Implementation of the research results. Based on the obtained scientific results, the morphofunctional characteristics of the liver of rats in the norm and under the influence of polypharmacy were determined:
Approved methodological recommendations: "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Conclusion No. 8n-r / 265 dated 14.03.2022 of the Ministry of Health of the Republic of Uzbekistan) and "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Uzbekistan, Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z 180 of 2022), electronic program No. DGU 1038 "Program for studying the comparative characteristics of morphological changes caused by polypharmacy in the liver."
The scientific results obtained in the study of morphological and functional properties and morphometric changes in the structure of the liver under the influence of polypharmacy have been introduced into the practice of the Samarkand branch of the Republican Specialized Oncological and Radiological Scientific and Practical Medical Center of the Samarkand City Medical Association (Order of the Ministry of Health of the Republic of Uzbekistan dated March 14, 2022, 8n-r / 265-No. and conclusion No. 8 n-z 180 of 2022). The implementation of the obtained research data allows developing methods for early diagnosis, treatment and prediction of organopathology by morphological parameters, improving the quality of life and reducing the number of complications.
The structure and scope of the dissertation. The structure of the dissertation consists of an introduction, three chapters, a conclusion and a list of references. The volume of the dissertation was 103 pages.
In this article, the author, based on an analysis of a number of sources, tried to reveal the education system of Turkey and Iran, its historical stages of development and features based on a comparative analysis of various sources. The author tried to objectively analyze the reforms and modernization of the education system in Turkey and Iran in the twentieth century, mainly using foreign sources. While the main changes in Turkey were associated with the advent of Mustafa Kemal after the 1920s, the emergence of such a European educational system in the life of the Iranian state was associated with the ascension of the Pahlavi dynasty to the throne in 1925. The article mainly compares two periods: 1920–30 and 1960–70. The reason is that it was during this period that great changes took place in the political, social, economic life and educational process of these two countries. An attempt was made to identify and show the results obtained using comparative tables. It also analyzes the education system, its reforms, the relationship between religion and the state, the alphabet, exact sciences and the implementation of the European educational process. Conclusions were made by analyzing the results of the reforms. The features of the education system in Turkey and Iran were identified and compared. In both countries, efforts were made to explain the changes after the Second World War, the Islamization of the education system and its impact on the quality of education. In conclusion, the results obtained as a result of the analysis were systematized and sorted. When writing an article, the author sought to develop and substantiate his conclusions using methods such as comparative analysis and the use of statistical data.
The following issues are analyzed in this scientific article: the significance and historical role of establishing diplomatic relations between the Republic of Uzbekistan and Japan. The huge role of ratification of the strategic partnership agreement between two countries is also shown. The peculiar specifics of the political system of Japan, including the nature, structure and basic functions of the parliament and the procedure for holding parliamentary elections, the place and role of the emperor’s institution in the political system, as well as the cabinet of ministers, are examined. The article considers the basis of the principle of forming the Cabinet of ministers, its role in the process of reforming the political system of society, the features of the political system, in particular the formation of a multi-party system, the reasons for success as a dominant party - the Liberal Democratic Party of the country, the role of the LDP in the process of modernization of the Japanese political system, the role of the Cabinet of ministersin the political system of society, the activities of the Japanese government led by Sh.Abe in the process of updating political system, the government’s program for the development of the country's economy, as well as the specifics of the practical implementation of this program, the activities of the parliament and the cabinet to amend the Constitution of the country, in particular, on articles 1, 4, 7, 9, 41 of the Constitution. Particular attention is paid to the processes of amending Article 9 of the Constitution, which deals with the issue of legal updating of the status of the Japanese armed forces, and on the basis of these changes will complete the "idea of creating" a normal Japanese army. The cabinet’s aspirations to expand the powers of the government by improving the legal norms of the Constitution, in particular by adding a special chapter 9 to the main law, are also considered. The article also shows the prospects for the development of the political system of Japan, where in particular the main attention is paid to the role and importance of accelerated economic development in the process of improving the political system. In addition, the influence of national values and traditions of Japanese society on the positive development of the political system is examined. At the end of the scientific article, conclusions are drawn about the political and legal conditions that are created by the desire of the Japanese government for the development of the political system.
The aim of the research work is to improve the results of treatment of patients with combined injuries of the pelvis and femur, by developing tactical and technical aspects based on the severity of the injury and the severity of the condition.
The object of the study was 130 patients with injuries of the pelvic and hip bones with concomitant trauma, treated at the Republican Scientific Center for Emergency Medical Aid and its Samarkand branch for the period 2016-2021 years.
The scientific novelty of the research work is the following: the structure and frequency of combined injuries of the pelvis and femur in the general structure of injuries, in the structure of injuries to the pelvis and femur separately were evaluated. the risk factors for the development of unsatisfactory results of treatment of concomitant injuries of the pelvis and hip, based on traditional clinical and diagnostic standards, have been determined; a direct relationship has been proven in the dynamics of the condition of the victims and the prognosis, taking into account the type and nature of segmental injuries; the device for external fixation for stable functional minimally invasive osteosynthesis has been improved and the possibility of expanding the indications for surgical treatment for combined injuries of the pelvis and hip in the early period of traumatic disease has been proved; the technical advantages of a complete set of an improved rod device for external fixation have been proved, the pelvic and femoral versions of which make it possible to use them for effective stabilization of the pelvis and hip separately during anti-shock measures, and for the final reposition of bone fragments; the direct dependence of treatment results on the proposed tactics of providing trauma care at an early hospital stage, depending on the type, nature, severity of pelvic and hip injuries, and the severity of the condition has been proved.
The introduction of research results. Based on the results of scientific research to improve the surgical aspects of providing assistance to victims with concomitant injuries of the pelvis and femur: based on the results of the development of a device for the treatment of fractures, a patent for an invention was obtained from the Intellectual Property Agency of the Russian Federation "Apparatus for the treatment of combined fractures of the pelvic and hip bones" (patent No. 2749897 dated 06/18/2020). The results obtained made it possible to improve the tactics of surgical treatment of patients, to shorten the period of hospitalization and the period of postoperative rehabilitation, to ensure the possibility of patients with minimal economic costs; on the basis of the results of scientific research on the diagnosis and treatment of concomitant injuries of the pelvic and femur bones, methodological recommendations were approved "Method for the treatment of victims with concomitant injuries of the pelvis and hip, depending on the severity" (Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z / 288 dated August 31, 2021 of the year). The results obtained made it possible to improve the quality of wound diagnosis and rehabilitation of patients with injuries of the pelvic and hip bones in concomitant injury; approved methodological recommendations "Tactics of rendering assistance to victims with combined injuries of the pelvis and hip, taking into account the severity of the condition" (Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z / 288 of August 31, 2020). The results obtained made it possible to improve the tactical and technical aspects in the treatment of injuries to the pelvic and hip bones, based on the severity of the injury and the severity of the patient's condition.
Scientific results have been introduced into the practical activities of healthcare, in particular, the Samarkand branch of the Republican Specialized Scientific and Practical Medical Center of Traumatology and Orthopedics, the Jizzakh Branch of the Republican Scientific Center for Emergency Medical Aid, the Samarkand branch of the Republican Scientific Center for Emergency Medical Aid (certificate of the Ministry of Health No. 08-09 / 18979 dated December 02, 2021). The proposed tactics for the treatment of combined injuries of the pelvis and femur made it possible to reduce the incidence of postoperative complications of excellent and good long-term functional results from 66.1% to 92.6%.
The structure and scope of the dissertation. The dissertation consists of an introduction, five chapters, conclusions, practical recommendations, a list of referencesand applications. The volume of the text material of the work is 111 pages.
Мамлакатимиз иқтисодиётининг тараққиётида муҳим бўғинлардан бири ҳисобланган транспорт тизими истиқлол йилларида мисли кўрилмаган бунёдкорлик ишлари билан жадал ривожланиб келмоқда. Узбекистон Республикаси Президента Шавкат Мирзиёев 2017 йил 14 январда Вазирлар Маҳкамасининг 2016 йил якунлари ҳамда 2017 йилнинг устувор вазифаларига бағишланган кенгайтирилган йиғилишида сўзлаган нутқида “Бугун замон ўзгармоқда, унинг талаби, олдимизга қўяётган вазифалари тобора ортиб бормоқда. Мана шундай мураккаб шароитда “Сен - менга тегма, мен - сенга тегмайман” деган кайфият билан ишлашнинг даври ўтди Халқимизнинг ишончини қозониш, унинг орзу умидларини рўёбга чиқариш учун фақат тинимсиз меҳнат, изланиш ва ташаббус кўрсатиб яшаш керак ’’[Мирзиёев, 2017 йил, 14 январь;] деб таъкидлаб ўтдилар.
The article discusses the issues of centralizing the storage and processing of information at the corporate level at textile enterprises, improving the mechanism of information support of the integrated quality management system and strategic management based on the electronic corporate information database proposed by the author, aimed at creating a unified corporate information environment.