All articles - Infectious Diseases
Number of articles: 657
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Clinical and laboratory characteristics of pneumococcual meningitis in the samarkand regionIn this article, the clinical and laboratory aspects of the course of pneumococcal meningitis (PM) in the Samarkand region over the past 10 years have been studied. Studies have shown that pneumococcal meningitis most often affects children under one year old (30%); in the clinical picture of the same intensity, general in-fectious, cerebral and meningeal symptoms are detected. The main percentage of cases of the disease is associ-ated with the primary lesion (70.3%). A high percentage of mortality and the formation of complications. Re-sidual effects are presented: asthenoneurotic syndrome (71%), sensorineural hearing loss (9%), cardiopathy (6%), arthritis (6%), hydrocephalus (5.5%), ataxic syndrome (2%), lesion of the cranial nerve (3.7%). The im-munochromatographic test for the presence of pneumococcal soluble antigen in the cerebrospinal fluid (Binax NOW - Streptococcus pneumoniae Test) used in our studies is a more rapid method for diagnosing pneumococ-cal meningitis.
Journal problems of biology and medicine -
The new coronavirus disease COVID-19 has spread rapidly around the world. In December 2019, the new coronavirus was first reported in Wuhan. Hubei province. China. In the following months, widespread transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the 2019 coronavirus disease (COVID-19), has been reported across all inhabited continents. In Uzbekistan, the first recorded case on March 6, 2020. Currently, at the time of this writing. 65,765 COVID-19 cases with a positive test and 2,289 deaths have been reported in Uzbekistan. Although awareness of the disease continues, information on pregnancy remains limited. -
The article presents a clinical case ot a severe course of covid infection in an elderly patient with comorbid pathology. The analysis of the causes of death and risk factors for severe and complicated course in this case corresponded to its classic components - age over 65 years, arterial hypertension, coronary heart disease, diabetes mellitus. metabolic syndrome and obesity. The role and lesions of the kidneys were discussed, the patient had proteinuria, hematuria as independent predictors of the critical course of the disease. Renal failure is common in patients with COVID-19 and can be the cause of multiple organ failure of lethal outcome. -
We examined 52 patients under the age of one year who Were hospitalized in the children’s Department 1 of SamMI in Samarkand in 2018 - 2019; 19 of them were under the age of 6 months; 29 boys and 23 girls. Staphylococci were isolated in 43 children, the control group consisted of 9 patients in whom staphylococci were not detected. A total of 215 strains of staphylococci were isolated from children's feces. And sensitivity to antibiotics (penicillin, streptomycin, gentamicin, levomycetin, tetracycline, cephalosporins, and erythromycin) was studied. Staphylococci are quite often and in large quantities sown from the feces of children with dyspeptic disorders. Staphylococci are characterized by the presence of pathogenicity enzymes and toxigenic properties. Dedicated staphylococci were sensitive to gentamycin and Cefotaxime. -
Study of systemic inflammation markers in the aspect of hiv - encephalopathy Development in childrenIn this article, the authors presented the results of clinical-neurological and immunological examination of 260 children with HIV - encephalopathy of various severity. All children included in the study studied the activity of HIV replication in mononuclears and other indicators that are candidates for the role of a predictive marker of the course of VCE. The analysis of the relationship between these indicators and the severity of VCE was also studied. The study evaluated the activity of 11-6, IL-10, TNF-alpha, C-reactive protein, СЗ, C4 complement components and the predictor significance of various parameters of systemic inflammation in the aspect of the development of symptomatic HIVE.
Doctor's Herald -
In most cases, sepsis is caused by gram-positive flora. However, in patients without hematogenous dissemination, gram-negative microorganisms were microbiologically confirmed. Diagnosis of sepsis is a very difficult question. About 30% of sepsis cases remain without bacteriological confirmation. About 40-45% of sepsis cases are caused by staphylococci. However. 80% of cases of surgical infection is combined with an anaerobic infection. Surgical treatment of sepsis is considered to be the most relevant. Especially sepsis due to inflammatory diseases of soft tissues, treatment should begin with an urgent surgical intervention. -
Modern epidemiological aspects of acute intestinal infections in the samarkand regionThe article discusses the results of the epidemiological analysis of the incidence of acute intestinal infec-tions registered in the Samarkand region in the period from 2012 to 2016. Based on the results of a survey of parents of children hospitalized in the Samarkand Oblast Infectious Disease Hospital for diarrhea, an analysis is made of the pathways and factors of infection, as well as the conditions that contributed to the development of the disease. The insufficient awareness of mothers about the rational feeding of children, the primary measures that parents should take when diarrhea syndrome occurs in young children (in particular, the signifi- cance and methodology of oral rehydration) has been identified
Journal problems of biology and medicine -
Clinical and epidemiological characteristics of women patients with gonorrhoea in samarkand regionThe data of 3 years period of clinical epidemiological studies of 120 female patients with gonorrhea living in Samarkand Region have been presented in the article. The features of epidemiology, clinical pictures of 38 patients with recent acute gonorrhea. 20 patients with torpid. 19 patients with sub acute and 25 patients with chronic gonorrhea have been shown at the contemporary level. The highest morbidity for gonorrhea is observed among the persons dealing with paid sexual service (29.41%) and unemployed women (53.92%). Gonorrhea is more often observed in 18-30 years ago group, that makes 79.41%. In descending recent acute gonorrhea urethra is involved into the process in more than 3d of women, i.c. in 76.47% of cases, cervical canal-100%, vulva-5.88% and vagina -2.94%. Ascending gonorrhea was observed in 13.16% of patients. In torpid, sub acute and chronic forms of the disease descending gonorrhea occurred in 59.37% of cases, ascending in 40.63%.
Doctor's Herald -
A new, highly effective complex method of treatment of patients with torpid, subacute gonorrhea in women has been developed in the presented in the presented article. It includes administration of i'm ccfriaxon, 1g, 2 times daily for 3 days with simultaneous combination of oral azitromycin, 0.25 g 2 times daily with the course dosage of 3 g and intravaginal suppositories, consisting of 2.0 g of cacao oil. 25mg of chimopsin, 0.02 g of gentamycin. As a result of therapy rapid control of inflammatory processes, 100% of recovery and sufficient decrease of postgonorrheal residual inflammatory phenomena (7.7% against 53.8% in the group of comparison)took place. -
Chronic viral hepatitis and tuberculosis are widespread as monoinfections. They are caused by the action of biological, socio-economic risk factors. In this article, we present materials on the epidemiological and clinical course of chronic viral hepatitis C and tuberculosis as a combination of infections, indicating an increase in the incidence, involvement in the epidemic process mainly of people of working age, and high mortality. -
Viral hepatitis and pregnancy remain one of the actual problems in obstetrics. In pregnant women, viral hepatitis is more severe than non-pregnant, and represents a serious danger to the mother and fetus. Pregnant women with this disease are considered to be at high risk, since gestation in this contingent of women is accompanied by a high incidence of complications (both from the mother and from the fetus) -
Results of the comparative analysis of landscape of summarized formats in patients with osteomielitis of different ageThe aim was to give a comparative description of the landscape of pathogens sown in patients of differ-ent ages with osteomyelitis. It was found that the leading microorganisms in children as monoculture were S. aureus and P. aeruginosa, and in adults this sequence was somewhat different: S. aureus, S.epidermidis, E. coli, P. aeruginosa. In children, S. aureus and S. epidermidis were the leading associations, and in adults E. coli and P. aeruginosa. Identified 7 differences related to sowing pathogens depending on age and microbio-logical prognostic criteria are important for the formation and prognosis of the disease
Journal problems of biology and medicine -
Analysis of epidemiological aspects on brucellosis of nurabad district of samarkand regionThe problem of brucellosis remains relevant in the Healthcare system in Uzbekistan. The reason for this is not a reduction in the incidence of brucellosis in some regions in the Republic of Uzbekistan. In the Nurabad district of the Samarkad region, there is a relatively large number of cases of brucellosis, which gave us the impetus to do this work. An in-depth analysis of the epidemiological aspects of brucellosis in patients recovered from 2015-2017 in the district hospital of the Nurabad district of the Samarkand region was carried out. In the Nurabad region, the incidence of brucellosis is mainly observed in people engaged in cattle breeding. It should also be noted that specific preventive maintenance is lame in the Nurabad district. This, in turn, increases the indicator of the number of patients with brucellosis in relation to other diseases
Journal problems of biology and medicine -
Clinical-epidemiological characteristics of mumps infection in children and adolescents in samarkand regionThe article presents clinic-epidemiological estimates of 263 patients with mumps infection for 2014 - 2016. Analysis of the data obtained showed, along with an increase in the incidence, a significant shift in the older age group (13-18 years), an increase in combined and severe forms of illness in adolescents and young men, and a shift in the seasonality of mumps in the hot season (May-July), In comparison with the literature data
Journal problems of biology and medicine -
Eulminant gangrene of genital organs (Fournier's disease, necrotizing fasciitis, fulminant gangrene of the scrotum, etc.) - acute necrotizing infection affecting the subcutaneous fatty tissue of the external genital organs and the perianal region of men; much less affects the genitals of women. The authors note the importance of an integrated approach to the treatment of Fournier's gangrene, which includes antibacterial, detoxication therapy, correction of disorders of homeostasis and metabolism, disturbances in functioning of organs and systems. Surgical treatment should be carried out without delay, in compliance with the principles of "aggressive surgery", i.e. should be as radical as possible with excision of subcutaneous fat. drainage of fascial spaces. -
Medical and social assisting to hiv-infected patients who use psychoactive substance with mental disordersRecently, the number one problem has been the progressive growth of HIV-infected drug addicts. [6]. Patients with HIV infection are a socially vulnerable group. The lack of a specialty, permanent work and work experience significantly reduce their income, limit the social security of sick leave, disability benefits, hinder health insurance and drug provision [1]. Considering that the infection caused by HIV introduces a number of psycho-traumatic factors into the lives of those infected: disruption or termination of interpersonal and social relationships, changes in relationships in the family and in sexual life, it can be assumed that HIV-infected patients have such psycho-emotions. -nal reactions, such as: apathy, feeling of helplessness, self-doubt, depression, depression, resentment, a tendency to tearfulness [7].
Journal problems of biology and medicine -
Repeated operations in chronic recommending hematogenic osteomyelitisThe results of surgical treatment of patients with chronic recurrent hematogenous osteomyelitis are ana-lyzed. The proposed method of surgical treatment of patients with chronic recurrent hematogenous osteomyeli-tis - longitudinal osteotomy, enlarged sequestralectomy with recanalization of the affected bone, provides the most radical sanation of the osteomyelitis and improves the results of treatment in this severe pathology
Journal problems of biology and medicine -
Perfection of technology of extracorporeal detoxification at the stages of surgical treatment of patients with mechanical jaundiceThe work was based on clinical studies of 72 patients with mechanical jaundice of benign genesis and with various malignant tumors of the hepatopancreatoduodenal zone operated in the surgical department of the 1 - city hospital in Samarkand for the period 2014-2017. In 64 patients, the cause of mechanical jaundice was cholelithiasis and stricture of bile ducts, liver echinococcosis. In 8 patients, mechanical jaundice was caused by pancreatic cancer, a large duodenal papilla, and hepatitis choledoch cancer. All patients underwent surgical interventions to eliminate MF and its complications
Journal problems of biology and medicine -
Study of the immune system of children with laryngeal papillomatosis on the background of antiviral therapyA comparative analysis of the immunological parameters in the dynamics (before and after) of standard therapy and after standard + immunotropic therapy was performed in 252 children with papillomatosis of the larynx at the age of 3 to 9 years who were on the examination and treatment in the surgical department of oto-rhinolaryngology TMA. in the state of immune response in laryngeal papillomatosis, unidirectional changes, most pronounced in children with continuously recurrent form of laryngeal papillomatosis, were revealed. In the dynamics of therapy, there was an improvement in the cellular and humoral immunity, improvement in the clinical state of children, and a decrease in the frequency of relapses.
Journal problems of biology and medicine -
Prognosis of specific spondylitis in patients with pulmonary tuberculosisThe developed prognostic matrix for a comprehensive assessment of the risk of spondylitis development allows a quantitative assessment of the likelihood of spondylitis in patients with pulmonary tuberculosis in var- ious combinations of risk factors.
Journal problems of biology and medicine -
Efficiency of fargals use in complex treatment of hiv-infected children with acute purified synusitisThe effectiveness of local treatment in inflammatory processes can be significantly improved through the use of scientifically grounded multi-component compositions, taking into account the etiology, pathogenesis, and the difference in the course of the process, where each component directly affects one or another inflammatory factor. Such a drug is FarGALS. Under our supervision were 62 HIV-infected children aged 6 to 16 years who were treated in the children's ENT clinic for acute purulent sinusitis. The use of FarGALS solution in complex treatment and rehabilitation of ENT-organs in HIV-infected children improves the hygienic index by 43%, reduces, up to complete reduction, inflammatory phenomena, enhances the nonspecific protective functions of the mucous membranes of the ENT organs and it is a pronounced positive effect on mucociliary transport of the mucous membrane of the nasal cavity and sinuses.
Doctor's Herald -
Clinical and epidemiological features of HIV infection in the Samarkand region are analyzed. A study of the clinical and epidemiological features of HIV-infected, as well as their specific treatment, revealed differences in the group of female and male patients. -
This article deals with the complications of pregnancy in women with genital tract infections along with impact of genital tract infections to the course of pregnancy and its outcomes. -
Cryoglobulinemia - importance in the development of extrahepatic manifestations in patients with viral hepatitis cCurrently, the association of chronic hepatitis C with various extrahepatic manifestations is becoming topical. The systemic generalized nature of the infection makes timely diagnosis and treatment more difficult. In the pathogenesis of extrahepatic manifestations, cryoglobulins arc crucial.
Doctor's Herald -
Results of retrospective and prospective analyses of the reasons of 117 cases of "a subtransami-nasaemia" (ST) of an extrahepatic origin are given in work. The range of the reasons of development of ST was very various. Thus diabetic mellitus, drug intake, dislipoproteinaemia and obesity are dominated. In this "quar-tet" the leading position of the induced ST by drug was taken.
