The aim of the study is to development of an algorithm for managing pregnancy and childbirth by studying the functional state of the mother-placenta-fetus system in pregnant women who have undergone COVID-19 in different trimesters of pregnancy.
The object of the study was 105 pregnant women who, were treated at the Samarkand Regional Perinatal Center and a specialized maternity center for pregnant women with COVID-19
Тhe scientific novelty of the research consists of the followings: for the first time in pregnant women infected with COVID-19, a relationship was established between the course of pregnancy, childbirth, the postpartum period and the development of complications depending on the trimester and severity of the disease; a direct correlation has been established between the state of the vessels of the mother-placenta-fetus system (resistance and pulsation indices, Endothelin-1 indicators), disorders in the hemostasis system (D-dimer, platelet aggregation) and the clinical course of the disease in pregnant women who underwent COVID-19; it has been established for the first time that the developed scale for assessing risk factors for non-developing pregnancy in women infected with COVID-19 (age, BMI, obstetric history, gestation period, hemostasis system status, endothelial function and severity of the disease) can serve as a prognostic marker of the degree of risk of pregnancy complications; it was proved for the first time that the choice of effective therapy for restoring hemodynamics in the mother-placenta-fetus system, in women who underwent COVID-19 at different stages of pregnancy, leads to a decrease in the number of thrombophilic complications.
Implementation of the research results. The results of the scientific research were introduced into the practical activities of the Samarkand Regional Perinatal Center by Order No. 128/1 of 01.09.2022 and the Samarkand City Maternity Complex No. 1 by order No. 58/1 of 03.10.2022. In pregnant women who underwent COVID-19 at different periods of pregnancy, changes in the mother-placenta-fetus system were determined using simple and effective research methods, such as ultrasound and Dopplerography, and this saved 53,000 soums; obstetricians and gynecologists, as well as neonatologists and therapists, are needed to diagnose signs of complications in the echocartin, that is, it has been proven that there is no need for other highly qualified specialists for this, due to the lack of need to train new personnel, state budget funds have been saved. With early detection of disorders in the hemostasis system in pregnant women with COVID-19: the period of stay of patients in the hospital was reduced from 10.5 days to 7.5 days and the number of hospital bed days was reduced; due to the reduction of the period of stay in the hospital for several days, the number of necessary drugs was reduced (on average, drugs are used for 1 day in the amount of 130,000 soums). Examination of pregnant women infected with viral diseases using simple and effective research methods such as ultrasound and Dopplerography served to save 85,000 soums: in the early stages up to 16 (10-11 weeks. - fetometry), 19-21, 32-34, 38-40 weeks of pregnancy; due to the absence of the need to use other research methods, it was possible to reduce costs by 23.5%; early detection of changes in the hemostasis system and endothelial dysfunction using fast, budgetary and effective research methods, contributed to the prevention of possible pregnancy complications, as well as the absence of the need to use long-term and expensive research methods, and this saved 106 000 soums: the coagulogram was checked in 105 (100%) patients, time was saved and efficiency was increased; endothelin-1 was also determined in 105 (100%) patients, efficiency was increased by 78.6%.
Improving the functionality of blood circulation in the uteroplacental and fetal-placental systems, a comprehensive analysis of possible complications during pregnancy and childbirth in women who have had viral infections, improving diagnostic, preventive and prognostic measures for managing pregnancy and childbirth contributed to the birth of live, full-term and healthy newborns in women who experienced COVID-19 during pregnancy, as well as a decrease in maternal mortality and perinatal mortality, 43% of women underwent rehabilitation in the postpartum period, 23.8% of women who underwent severe COVID-19 improved their quality of life.
To introduce scientific novelty on the topic “The impact of COVID-19 on the state of hemodynamics in the mother-placenta-fetus system in pregnant women”, a letter was sent to the Ministry of Health from Samarkand State Medical University on November 9, 2022 under No. 4295 (Conclusion of the Ministry of Health No. 8 n-z / 679 of December 15, 2022).
The structure and volume of the dissertation. The content of the dissertation consists of an introduction, five chapters, conclusion, list of used references. The volume of the dissertation consists of 113 pages.
We conducted a retrospective study of 75 cases of pregnancy and childbirth in women with obesity, which were divided into 2 groups: group 1 - 45 pregnant women with obesity and group 2 - 30 pregnant women with overweight. The control group consisted of 16 healthy pregnant women with normal weight growth rates. The effect of overweight and obesity in women on the course and outcome of pregnancy and childbirth was studied. In obese pregnant women, the risk of developing hypertensive conditions increases 3.5 times. Gestational hypertension was detected in 15.5%, and preeclampsia in 26.6% of obese pregnant women. Gestational pyelonephritis was detected in 20% of group 1 and in 10% of pregnant women in group 2. In women of the 1st group, in 22% of cases, the pregnancy was terminated before 12 weeks. Physiological childbirth in patients of group 1 occurred in 68.5% of cases, and in group 2, it was 80%. The study of anthropometric data of newborns showed that 28.5% had an increased body weight, and 25.7% of newborns had indicators of a large fetus.
This research is about the development of an important part of Chinese literature -women’s literature in XX century. In the beginning of XX century the number of women writers who wrote fiction works increased rapidly. The uneasy situations of the country such as revolutionary movements in the beginning of XX century, China-Japan war, monopole government of Mao Zedong, persecuting the democratic movements, deporting intelligent people to the “re-educating” camps and other conditions were not able to obstacle the women to enter the literature world. On the contrary, interfering of women in social-politic life of the country got stronger in the second part of the XX century. The various movements of women, journals and newspapers and societies of women were organized. The role of women in social life became more noticeable and women literature developed more. Women writers such as Bin Sin, Lin Shukhua, Lu In, Din Lin, Syao Khun, Shi Pinmey, Dzao Min, Lyui Bichen, Chjan Aylin got an important place in social-politic and moral-cultural life of the country with their works. Many of these women participated actively in literary processes and public events. In this article some of the mentioned women writers’ life and work will be discussed in detail. The women writers mentioned in this article are confessed not only in China, but also in the world’s literature. The problems risen in women’s works, the real events described by them play a significant role in gaining more knowledge about the history of China in the first half of XX century and enriching our imaginations regarding to literature processes.
This article reveals the essence of the concept of "women's literature" and its modern views on the concept. The debut of female art in Uzbek and Chinese literature, the formation of "female literature" in China are also highlighted. The literary environment of the khanates in Uzbek literature and the position of women in them, as well as socio-political events stimulating the creativity of women in Chinese literature.
Coronavirus disease severe acute respiratory syndrome COVID-19 quickly spread throughout the entire dune at the pandemic level in 2019 year. Due to changes in the immune system and respiratory physiology, pregnant women are prone to severe viral pneumonia, which can lead to a number of obstetric complications, in particular, fetoplacental insufficiency. In this regard, the purpose of the study was to investigate the pathological changes of the placenta in pregnant women infected with coronavirus COVID-19.
In this article consecrated and analyzed various aspects of discrimination in sphere of work and occupations and differentiation of legal regulation of work of the women and persons engaged in performance of family duties. In it the author pays special attention to legal bases of prohibition of discrimination in the sphere of work and occupations, and also puts forward her offers to improve the legislation concerning differentiation of legal regulation of work of the women and persons engaged in performance of family duties
The article discusses the development of female creativity in the Saudi literature and provides an overview of the works of the most famous Saudi women writers nowadays. The central place in the works of Saudi writers takes the problem of the “women’s issues”, which is common for general Arabic literature as a whole at the stage of its formation, but which has its own peculiarities in Saudi literature, related to the preservation of the predominant role of men in matters of family and marriage.
This article discusses the reforms carried out in China in the last quarter of the twentieth century, population growth, strong economic growth, and other factors that have made China one of the leading countries in the world and has a say in world politics. Naturally, all this has a serious impact on culture, spirituality, art and literature. A
generation of writers of the 1970s entered the world of literature. Also during this period, the
relatively older generation continued their creative activity. With regard to literature in
general, women's literature has undergone great qualitative changes. Now writers have begun to write about false ideals, reforms, class interests, and their impact on the fate of humanity. One of the most famous representatives of women's literature of the 21st century is the talented writer Tiao Ye.
It is observed that the development of the genre in the Turkish narrative of the republican period took place on the basis of folk literature and language, as well as the traditions of world literature. The genre of the story has shrunk in form, socialized in content, and diversified according to the system of images. In the narrators’ ways of artistic interpretation of reality, observation, nationalism, sociality, and philosophy were manifested in a common state. It was a testament to true innovation in Turkish storytelling. This article examines the peculiarities of modern Turkish storytelling of the 1940s, as well as the work of the great writer of the period Orkhan Kamal. It is obvious that the Turkish stories created in the 30s and 40s of the 20th century vividly depicted the pure feelings in the hearts of the helpless people who lived in the dark days of the past, and resolutely renewed the traditions of historical literature. Such updates in the literature of the period are of special importance in the work of Orkhan Kamal. Kamal is one of the great representatives of Turkish literature and is known to the world for a number of stories and novels. In his stories, the image of ordinary workers is of special importance. Orkhan Kamal's stories are full of children's heroes and fragments of their lives. The main part of this type of child images is worker children. The article also analyzes the author's stories, such as "Sleep", "Strange Child", "First Bread" with the participation of children's heroes. Also, the stories of O.Kamal from the life of women are unique. The fate of women who involuntarily go astray, teenage girls looking for ways to escape poverty through song and dance, maids in rich families, young girls deceived by the love trade determine the content of the author's stories on this topic. The article also emphasizes the author’s stories on the subject.