All articles - Respiratory System
Number of articles: 472
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Role of azonotherapy in the treatment of exudative sinusitisThe search for new conservative approaches in the treatment of exudative sinusitis is one of the urgent problems of modern rhinology. One of the existing methods of treating exudative sinusitis is at present a ra-tional combination of general measures of influence on the body with local treatment. In this regard, we pro-pose the use of medical ozone in the treatment of exudative haymarites as an independent agent and in combi-nation with ampicillin. A comparative analysis of the efficacy level of ampicillin in combination with O3 shows the advantages of this technique and its mechanism. The results of treatment of 100 patients are suggested. All patients underwent puncture, catheterization of VPC with subsequent washing and administration of drugs. Despite this, in patients 1 - group 15% of patients, 2 - group 6.66% of patients, 3 - group of 40% of patients had a short-term effect with subsequent relapse of the disease.
Journal problems of biology and medicine -
The study of the features of the copd flow on the arterial hypertensionAccording to WHO about 250 million people worldwide suffer from chronic obstructive pulmonary dis-ease (COPD) which has the second highest prevalence of non-communicable diseases according to global sta-tistics. The prevalence of COPD according to WHO is 9.3 per l thousand population among men and 7.3 per 1 thousand population of women older than 40 years. The incidence of COPD is increasing progressively and it is only cause of death with increasing number of reported cases. WHO predicts COPD will become the third most common cause of death after stroke and myocardial infarction in 2030. The most common comorbidities in COPD is hypertension (28%) which is caused by common risk factors. COPD combination with hyperten-sion increases the risk of hospitalization and mortality compared with patients with COPD without comorbidi-ty. In connection with the above stated study of respiratory function and functional changes in the heart in pa-tients with COPD combined with hypertension is very important
Journal problems of biology and medicine -
Chronic viral hepatitis and tuberculosis are widespread as monoinfections. They are caused by the action of biological, socio-economic risk factors. In this article, we present materials on the epidemiological and clinical course of chronic viral hepatitis C and tuberculosis as a combination of infections, indicating an increase in the incidence, involvement in the epidemic process mainly of people of working age, and high mortality. -
Prognosis of specific spondylitis in patients with pulmonary tuberculosisThe developed prognostic matrix for a comprehensive assessment of the risk of spondylitis development allows a quantitative assessment of the likelihood of spondylitis in patients with pulmonary tuberculosis in var- ious combinations of risk factors.
Journal problems of biology and medicine -
Syndrome of endogenous intoxication in children and its influence on the clinical currency of chronic rinosinusiti on the background of the chronic bronchitisThe development is due to the use of large doses of antibiotics, as this causes the death of a large number of pathogens and abundant entry into the blood of endotoxins, in which the severe condition of the body is ag- gravated by a sharp violation of hemodynamics, circulation and perfusion of tissues. In the pathogenesis of shock, the leading place is occupied by the violation of micro- and macrocirculation
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Complex echographic diagnostics of heart lesions in children with pneumoniaThis work will be based on the results of a comprehensive standard survey of 80 children. Various mani- festations of the pathology of the cardiovascular system, as well as changes in the data of laboratory and func- tional research methods in children of the main group with pneumonia, were accompanied by pronounced gen- eral clinical and local symptoms, which were stopped as the inflammatory process subsided. It should be noted that the functional changes were electrographically expressed in children mainly in the form of sinus tachycar- dia. Complex echographic diagnosis of heart lesions in pneumonia in children is a promising non-invasive method of research, which makes it possible to obtain information about the state of the heart in patients with pneumonia
Journal problems of biology and medicine -
Algorithm of early detection, prediction of cardiac-vascular complications in children of early age acute pneumoniaDue to the developed criteria to determine the likelihood of myocarditis in infants with pneumonia, made possible the formation of high-risk groups for adverse outcome of pneumonia. This will increase the likelihood of the development of myocarditis in children and the effectiveness of the therapy, to reduce the incidence of morbidity of acute pneumonia and significantly reduce the number of complications, and thus mortality rate
Journal problems of biology and medicine -
Efficiency of fargals use in complex treatment of hiv-infected children with acute purified synusitisThe effectiveness of local treatment in inflammatory processes can be significantly improved through the use of scientifically grounded multi-component compositions, taking into account the etiology, pathogenesis, and the difference in the course of the process, where each component directly affects one or another inflammatory factor. Such a drug is FarGALS. Under our supervision were 62 HIV-infected children aged 6 to 16 years who were treated in the children's ENT clinic for acute purulent sinusitis. The use of FarGALS solution in complex treatment and rehabilitation of ENT-organs in HIV-infected children improves the hygienic index by 43%, reduces, up to complete reduction, inflammatory phenomena, enhances the nonspecific protective functions of the mucous membranes of the ENT organs and it is a pronounced positive effect on mucociliary transport of the mucous membrane of the nasal cavity and sinuses.
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Most of the deaths in botulism are due to acute respiratory insufficiency (ODN) before the resuscitation stage. By the severity of the main process the patients were distributed as follows: the patients with severe forms were 7 (23%), medium heavy - 13 (42%) and light-11 (35%). The duration of stay of patients in the hospital amounted to 12,93 ± 0,62 ward-days. The patient is observed in outpatient conditions for 2-3 months after discharge from the stator, if they have acute respirator)' diseases, the patients arc hospitalized because their lung survival is not fully restored. -
The aim of the work was to assess the state of the immune system of children with out-of-hospital pneumonia, comparative analysis of the main parameters of the immune system show ed that the inclusion of an immunocorrec-tor for bronchomunal according to the scheme contributes to a more positive clinical and immunological dynamics, correcting the broken links of immunity. -
Orthodontic state of dental anomalies in children with chronic tonsillitis and bronchitisSocio-mcdical retrospective studies, clinical and dental examinations were conducted among children aged 7-15 years with chronic tonsillitis and chronic bronchitis. During the examinations, children's pathology, somatic pathology and dental anomalies (tooth anatomy and dental anomaly) were assessed using a number of modern measurements, such as frequency, severity and anamalia. An attempt was made to justify the importance of somatic diseases in the development and formation of dental anomalies in comparison with the control group and morphological norms.
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Recurrent bronchitis is a special nosological unit that requires a careful approach on the part of pediatricians, since it is a risk factor for the subsequent development of a number of chronic respiratory diseases. The disease occupies one of the leading places among respiratory diseases, the frequency of which in the structure of bronchopulmonary diseases, according to different authors, ranges from 5 to 40% [5, 14, 16]. -
To assessing the severity of radiographic changes in the neonate with respiratory distress syndromeX-ray examination of 100 newborns was carried out, 50 of them were newborns and 50 were premature infants with grade I and II prematurity. Newborn children born with syndrome of respiratory disorders (SRD) require special attention from the first days of illness and professionally competent medical tactics. At X-ray examination of premature newborns with pneumonia, the predominance of SDR characteristic features was observed. Refinement of the degree of severity of the SDR of the newborn with pneumonia allows the most ac-curate and objective assessment of the severity of the sick child. The results of X-ray studies of pneumonia in newborns allow us to conclude that they need to be carried out in the neonatal period. The X-ray method for assessing the degree of severity of SDS in pneumonia of newborn infants, especially premature infants, and with intrauterine growth retardation syndrome is convenient for its non-invasiveness, minimal radiation expo-sure to the subject, a wide range of indicators and information rich in morphology, which contributes to the timely correction of complex treatment, especially at the risk of SDR, reducing the development of posthypoxic complications of the adaptation period.
Journal problems of biology and medicine -
Status fibrinolytic activity of exudate in patients with chronic purulent maxillary sinusitis in a comprehensive treatment using thiotriazolineThe peculiareties of the tiotriasolinum influence on the exudate fibrinolytic activity of maxillary sinuses with local and general application in a multimodality therapy of patients with chronic purulent maxillary sinus-itis have been studied. A standard couse of treatment without tiotriasolinum application (control group) has been carried out in 20 patients with chronic purulent maxillary sinuses and in 43 patients the treatment has been combined with a local and general application of tiotriasolinum. It has been established that the total fi-brinolytic activity was significantly reduced in the process of treatment. Tiotriasolinum application probably decreased non-enzymatic fibrinolysis in total exudate fibrinolytic activity of maxillary sinuses and shortened the term of treatment
Journal problems of biology and medicine -
Chronorhythms secretory ig a in patients with chronic purulent maxillary sinusitisIt was found that secretory IgA level in maxillary exudate has significantly day-night periodity. Two points of maximum level were indicated at 6.00 a.m. and 3.00 p.m. At the same time minimum level was found at 10.00 a.m. and 9.00 p.m. The investigation of proteolytic, fibrinolytic activity; activity of oxide-renewing processes are presented complex negative influence on secretory IgA production in cases of chronic purulent maxillary sinusitis in determined hours. Received results will serve one of the criterions at development of chronotherapeutic therapy in chronic purulent maxillary sinusitis treatment
Journal problems of biology and medicine -
Quality of children and adolescents life with pulmonary tuberculosis depend- Ing on existence of the accompanying pathologyWork is devoted to studying of life quality parameters of children and adolescents with tuberculosis. Laboratory and instrumental methods examination of patients do not cover all aspect of tuberculous infection and do not allow valuing the condition of children and adolescents with pulmonary tuberculosis. At analysis of life’s quality there is full possibility to define the influence of the disease on physical, psychological and social aspects of the organism’s functioning. The analysis of quantitative indexes children and adolescents quality of life was conducted depending on accompanying pathology. For research was used the questionnaire of Pediatric Quality of Life Inventory - PedsQL. Questionnaire of PedsQL 4.0. includes 23 questions, incorporated in 4 scales. Every question has 5 variants of answers: "no", "hardly ever", "sometimes", "often" and "almost always", from which it is needed to choose one, most going near a situation.
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Pneumonia in children, despite significant advances in prevention and treatment, still remains one of the most pressing problems in pediatrics. [3,5,16,18]. In recent years, there has been an increase in morbidity in children, and mortality from this disease remains relatively high. In real practice, especially in outpatient settings, early diagnosis and rational therapy of pneumonia in children are serious problems. -
Diagnostic significance of il-8 and il-12 in various forms of interstitial lung diseaseIn patients with ILD, there is a multidirectional change in the production of cytokines, depending on the stage of the disease. The acute period of the disease is accompanied by a marked increase in the cytokine IL-8, and a subacute period of the change in the cytokine IL-12.
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Evaluation of initial vegetative tone in children perennial allergic rhinitis on clinical signs tablesWere studied the state of the initial autonomic tone in children perennial allergic rhinitis. Among 42 patients (68,9 per cent) were persistent, and 19 (31,1 per cent) – intermittent form CT. According to the analysis of clinical signs IWT in 28 (54.9 per cent) of children identified CT status, the prevalence of parasympathicotonia (vagotonia), 28(54,9per cent) - eatonii (balanced state of the ANS alone) – 9 (17,6%) of sympathicotonia. In General, CT is not dependent on clinical course, characterized by increased tension of the parasympathetic mechanisms of the ANS. the results indicate about the relationship between IWT and clinical course CT. You can assume the existence of a similar connection with the treatment CT
Journal problems of biology and medicine -
Hyperventilation as a manifestation of emphysematous-interstitial X-ray symptom in paecilomycosisThe development of generalized emphysema is possible with allergic bronchial asthma of pccilomycotic etiology. The aim of the study was to evaluate the lung hyperventilation radiographically as a manifestation of the emphysematous-interstitial X-ray symptomatic complex in pecilomycosis. Based on the data of long-term observations, we studied the radiographs of 74 patients with bronchial asthma aged 19 to 70 years. The radiological picture and types of emphysema depended on the degree and localization of valvular blockage of the bronchi. In the early period of bronchial asthma, the radiologic picture of the lungs does not differ from the usual background or is manifested by an increase in the transparency of the pulmonary fields, the expansion of the lung area and the impoverishment of the pulmonary pattern. Radiographic changes in the lungs arc observed in patients with a prolonged course of the disease and manifest as an enhancement of the pulmonary pattern due to the interstitial componentwith a mesh-cellular deformation in the middle-lower regions of one or both lungs, the presence of small-focal shadows located along the vessels of the bronchi. When the broncho-pulmonary system is affected by fungi of the genus Paccilomyccs, various forms of emphysema develop, which radiographically manifest in the form of an emphysematous-interstitial X-ray symptomatic complex and are most nonspecific in X-ray diagnostics. Changes indicate different manifestations of symptoms of bronchial obstruction and are combined with a clinic characteristic of obstructive syndrome.
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Evaluation of the quality of life of patients with diseases of ent-organs on the background of ronhopathyThe aim of the study was to evaluate the results of polysomnography in patients with diseases of the up-per respiratory tract on the background of ronchopathy. We studied 50 patients with ENT diseases who were in the ENT department of the 3rd clinic of the Tashkent Medical Academy in 2015-2017. These patients were di-vided into 2 groups. The first group consisted of 30 patients who had a mild degree of ronchopathy. The second group consisted of 20 patients with a moderately severe degree of ronchopathy. All patients underwent a com-prehensive examination, including polysomnography. The study showed that polysomnography is an effective diagnostic method that allows the distribution of bolt levels by degrees of ronchopathy, snoring intensity, ef-fects on other organs, is also an indication for timely treatment of diseases of the upper respiratory tract for the prevention of obstructive sleep apnea.
Journal problems of biology and medicine -
Practical recommendations on application of the developed biocompatible implant "geprotsel" for the prevention and treatment of disorders of aero - and hemostasis in surgery of the lungsVSU "RPMZ named Akad. V. Vakhidov street" together with NYSAFP Academy of Sciences of Uzbeki-stan developed a new aerial and hemostatic implant "Gabriel" which has passed preclinical testing. The article presents the results of clinical studies of the developed implant. Studies have shown that the use of a biological implant "Geprotsel" has reduced the need for additional single stitching lung tissue to ensure adequate Aero-and hemostasis from 38.2% to 11.4% and multiple strengthening seams from 29.4% to 5.7% (χ2=7,706; Df=2; P=0.021). The introduction of the domestic biological implant into lung surgery allowed to reduce the period to achieve Aero-and hemostasis from 32.8±2.5 to 12.5±1.2 minutes (P<0.001), the total duration of the operation from 135.6±6.1 to 107.2±4.7 minutes (P<0.001), as well as to reduce the duration of pleural drainage from 3.38±0.31 to 2.09±0.06 (P<0.001) and the entire period of hospitalization from 12.1±0.4 to 10.7±0.2 days (P<0.01)
Journal problems of biology and medicine -
The prevalence of recurrence of obstructive bronchitis in childrenThe descriptive-evaluative method of epidemiological research was used in the course of the research, a retrospective analysis of 12869 case histories of children, who were hospitalized in the period from 2015 to 2017 years due to recurrence of obstructive bronchitis was carried out. We obtained data on the frequency of occurrence of children with recurrent obstructive bronchitis. By periods of the year, the incidence of recur-rence of the disease in children is in the form of a “wave-like” curve, the severity of which largely depends on climatic conditions. Recurrence of obstructive bronchitis is more common in children at the aged 6 months to 2 years, and the peak rise in incidence occurs between the 2nd and 8th month of life. Basically 1 episode of bron-chial obstruction was observed.
Journal problems of biology and medicine -
Clinico-functional features of the nose in children with congenitial cleft lip and palateAccording to WHO, the birth rate of children with congenital cleft palate in the world averages 0.5-1.5 per 1000 newborns. Despite the mandatory set of measures taken at an early age, adult patients with congenital cleft palate have severe morphological and functional disorders that grossly impair aesthetics, phonetics, chewing and swallowing functions [8]. Congenital cleft palate is a common multifactorial malformation and occupies a leading place among all congenital malformations of a person. According to experts, congenital pathology of the maxillofacial region ranks 3rd-5th among all congenital malformations in humans and, on average, one child is born with a cleft palate for 600-1000 newborns [5].
Journal problems of biology and medicine -
The role of indicators of cytokins and markers of inflammation In development of complications in acute inflammatory diseases of upper respiratory ways in childrenBased on a survey of 167 children with acute inflammation of the upper respiratory tract, the features of the cytokine status in children with acute inflammatory diseases of the respiratory system were identified, which were expressed in the activation of IL-1, IL-8 and TNF-a, depending on the development of the inflammatory process. The relationship between changes in traditional clinico-laboratory indicators for acute inflammatory diseases of the respiratory system that determine the severity of the disease and changes in levels of markers of inflammation, in particular C-reactive protein, is established.
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