No. 2 (87) (2016) Problems of biology and medicine

Статьи

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  Functional status of kidney and upper urinary tract in congenital obstructive uropathy in children Comparative evaluation of the results of a comprehensive survey of children with congenital obstruc-tive uropathy revealed that children with congenital hydronephrosis, obstructive and reflux megaureter I de-gree obstruction of the functional state of the kidneys do not suffer. At the II degree obstruction of the func-tional state of the renal parenchyma is not deteriorating significantly, this is confirmed by the lack of trust differences dopplerographic (the IR), rentganplanimetry (RKI and PI) indices with normative data. When III degree of obstruction there is a violation of kidney function on the affected side, this translates into a signifi-cant reduction of the renal parenchym and the increase in rates on US IR, lower PI values at the excretory urograms.

  F Mavlyanov, U Khayitov

  61-64

  103   47

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  К вопросу этиопатогенеза и диагностики преждевеременного разрыва околоплодных вод Premature rupture of amniotic fluid is one of the most problematic issues of modern obstetrics. This pathology occurs in 2.7–17% of cases [1]. However, in preterm birth, its frequency ranges from 30 to 56% of cases [1, 6].

  G Eltazarova, Kh Holmurodov, I Zhumaev

  203-205

  62   32

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  Study and evaluation of endogenous intoxication and activity of antioxidant system of blood in women in the dynamics of worn copper-bearing intrauterine devices With the development of iron deficiency anemia in women with intrauterine marked imbalance in the system of oxidation of glutathione - glutathione peroxidase structure, accompanied by increased activity of glutathione reductase and glutathione. A clear-for regularities between the reduction of glutathione peroxi-dase with a decrease in plasma SH - groups and increase degradation proteins (carbonyl compounds)

  M Khamdamov

  98-100

  63   22

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  Course of prolonged jaundice in newborns and the role of torch infections Aim of given research was included to study the changes of clinic laboratory indices in prolonged hy-perbilirubinaemias occurring in TORCH in infections. 86 patients at age from 1 to 2 months were examined in the neonatological department of RCHMMC. In all cases hyperbilirubinaemia continued over 14 days. The results of our research showed that the patients were determined evident disturbances of biochemical indices: hyperbilirubinaemia, hypoproteinaemia, hypomagnaemia, hypoglycaemia, increase C- reactive pro-tein, increase of hepatic tests. So infectious factor in prolongedhyperbilirubinaemia in neonatal period of children may cause in cases

  M Khazratkulova, A Khamidova

  96-97

  57   24

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  Comparative analysis of efficiency of hormonal therapy in advanced prostate cancer patients The study included 235 patients with advanced prostate cancer (PCa). There was provided compara-tive study of the effectiveness of the treatment methods, based on combination of the biosynthesis of andro-gen suppression (LHRH analogues) and prevent the binding of androgens (anti-androgens) to their receptors in the prostate tissue - hormone "maximal androgen blockade" (MAB). Certain path we select the optimum mode of hormonal therapy, depending on prognostic factors have led to improve treatment outcomes and quality of life of patients with advanced prostate cancer

  M Tillyashaikhov, Sh Yusupov, E Boyko, R Valieva

  92-95

  80   18

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  Clinical and laboratory characteristics of osteoporosis in women with rheumatoid arthritis Overall, 113 female patients with rheumatoid arthritis (RA) had examined. From 16.9 to 48.7% of patient’s analyzes revealed clinical symptoms of osteoporosis (OP). According to the results of questionnaires, 87.6% of patients need to analyze parameters of calcium-phosphorus metabolism. The level of blood calcium was below than 2.2 mmol/l at 65.5% of patients, and the level higher than 2.8 mmol/l revealed at 15.9% of patients respec-tively. It found an increased activity of acid phosphotases (APs), parathyroid hormone (PTH) - markers of bone resorption and decreased alkaline phosphatase activity (ALPs), calcitonin (CT) - bone formation markers. The results of computed tomography (CT) and rentgendensitometry showed that, 40.0% of patients had signs of I de-gree, at 26,7% - II degree and 33,3% - III degree of osteoporosis (OP)

  L Tashinova, K Abdushukurova, M Mardonova, E Toirov

  89-91

  83   20

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  Clinical characteristics of gout, combined with metabolic syndrome In 49 patients (mean age - 50.6 ± 1.6 years, duration of disease - 9.4 ± 1.7 years) male gout were investigated anthropometric data, lipid profile, depending on the extent of the clinical and laboratory parameters. It has been es-tablished that the basic 3 clinical factors of the metabolic syndrome - obesity, hypertension, diabetes mellitus occurs in 49.3% of patients with gout. Dislipedemiya, hypercholesterolemia and increase in low density lipoprotein and very low density detected in 60,0-67,3% cases. In patients with urolithiasis frequency, severity of the violation rate of lower limb function, the number of affected joints, the number of subcutaneous tophi, arthritis incidence in the last year, the duration of the latest exacerbation and severity of gout own index higher than that of patients without meia-bolicheskogo syndrome. The degree of hyperuricemia and duration of the disease have a direct correlation with the degree of increase of total lipids and cholesterol in the blood serum

  I Sultonov, E Toirov, N Ishankulova

  86-88

  112   28

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  Causes of formation of groups frequently ill children associated with maternal medical history The article presents the history data somatic maternal health and obstetric history weighed 146 fre-quently ill children (FIC) and 50 DDL. Revealed that anemia in mothers FIC was registered in 88.3% (146 - 129) cases. Similar results were obtained in studies of anemia in mothers DDL. Among the chronic diseases occupies a special place chronic tonsillitis (65.7%) and chronic pyelonephritis (33.5%), which is much less than recorded (respectively 12% and 8%) in the DDL mothers. It should be noted that chronic foci of infec-tion have a depressing effect on the immunological status of mothers and create preconditions for the devel-opment intrauterine infection (IUI) fruit. There is no doubt that a child born with IUI may be frequently ill

  X Sirojiddinova, M Abdullayeva

  83-85

  93   22

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  Clinical character of patients with transient ischemic attacks We studied the clinical character of patients with transient ischemic attack. Present results of a study of 107 patients with TIA. All patients underwent clinical and neurological examination, ECG, EEG and Doppler ultrasound. TIA in young age based on medical history and neurological data and depends on the pool of defect. Most informative methods in patients with TIA proved Doppler ultrasound which reveals vascular disorder in almost all patients studied

  Sh Ruzieva, M Mamurova, S Khakimova, A Jurabekova

  79-82

  112   25

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  Parameters endogenous intoxication and heart rate variability mother threatening preterm labor infectious genesis The article examines the prognostic value of heart rate variability parameters and endogenous intoxi-cation in threatening preterm labor. Significant differences in heart rate variability parameters of endogenous intoxication and the relationship between these parameters to evaluate the course of pregnancy. The most informative for this purpose are such as IN, PAPR, as well as the ratio of MDA/catalase, MSM 254 , MSM

  G Rabbimova

  75-78

  146   29

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  The frequency and for chronic pain in patients with parkinson's disease We studied the incidence and course of chronic pain in patients with Parkinson's disease (PD). The study included 130 patients. All evaluated on a scale Hyun-Yar, on the Unified Parkinson's Disease Rating Scaleу (UPDRS) and visual analog scale (VAS). All patients had wound diary pain scores. In patients with Parkinson's disease showed a reduction in vibration sensitivity. Chronic pain is observed in 52% of patients with Parkinson's disease at the same time at the early stage 36% of patients in the late stage 64% of patients

  Sh Ollanova, Sh Eshimova, M Mamurova, A Jurabekova, N Abdullayeva

  71-74

  165   30

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  To the features manifestation and treatment of mild craniocerebral trauma Present research includes data of complex investigation and treatment of 60 patients with mild cranio-cerebral trauma. 30 patients of them recieved the traditional treatment as well as nootropic drugs (1 st - group), the rest 30 patients underwent traditional treatment (2 nd - group). All patients underwent complex clinical and instru- mental investigation, which included X-ray, electroencefalographical, ophtholmological, computed tomography and magnetic-resonance imaging investigations. Applying nootropic drugs on mild craniocerebral trauma contrib-uted to the reduction of common brain symptoms and focal symptoms

  N Norkulov, A Chodiev, N Ravshanov, S Norkulov

  68-70

  76   24

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  Especially genital prolapse in women of reproductive age and the choice of effective methods of contraception for them The article describes the factors leading to the development of prolapse of genitals, are described in detail peculiarities of genital prolapse women of reproductive age, the recommendation of his choice of the most effective methods of contraception for women with genital prolapse

  N Nasimova

  65-67

  83   28

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  Status of neurological status in newborns undergoing asphyxia The purpose of work consisted in assessment of the neurologic status of the newborns who were born in condition of asphyxia varying severity.48 newborns aged from 0 till 28 days which were born in a condi-tion of asphyxia of varying severity were examined. It is revealed that the characteristic clinical and neuro-logical symptoms has dependence on the severity of asphyxia of newborns, and also is followed by charac-teristic changes on a neurosonography, pathological changes increases in process in severity asphyxia ofnewborn children

  M Abdullayeva, I Shukhratzoda

  8-10

  147   29

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  Electroencephalography epilepsy in different age groups Study elektroenctphalographical parameter in epilepsyin different age groups. Examination of 168 pa-tient with epilepsy, is included a group of children early young age a group of adults and adolesance age. The analysis EEG in children is shown in 76% of bioelectrical activity of the cerebrum does not correspond to the age rate. In the elderly age have place partial epileptic stroke for confurmation of epilepsy age playsan im-portant trole

  N Kudratova, L Khamrayeva, N Abdullayeva, A Jurabekova

  56-60

  209   45

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  Neuroimeging and neurophisiologikal studies in children with tics We studied in neuroimaging and neurophysiologic studies in children with tics. Examined more than 180 children aged 7-12 years. Children performed clinical and neurological examination, EEG psychological testing, brain MRT. As a result, the survey revealed that children with tics are characterized by lower values of power of alpha rhythm in the occipital compared with healthy children. Significant hemispheric asym- metry of the spectral power of alpha rhythm is not mentioned

  A Kayumova, L Khamrayeva, N Dzhumaeva, A Jurabekova

  53-55

  131   37

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  Charakteristic clinical manifestations of hypoxic ischemic injury in newborns with acute The work includes the study of the clinical manifestations of hypoxic- ischemic injury in newborns with acute. All children conducted clinical and neurological examination, neurosonography, radiography thymus. Children with cerebral ischemia prevailed hypertension - hydrocephalic syndrome and movement disorders. Adverse symptoms were considered to change the brain parenchyma. The presence of an enlarged thymus gland indicates the combined CNS and the immune system during hypoxia

  N Dzhumaeva, L Khamrayeva, A Kayumova, S Khakimova, A Jurabekova

  49-52

  123   20

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  Medical and surgical activities carried out in simultaneous pathology in women The research is based on analysis of results of surgical treatment of 200 patients with different con-comitant diseases of the abdominal cavity, which was carried out a simultaneous surgery. Comparative study of two statistically comparable groups of patients who performed simultaneous and single operation, clinical and laboratory studies have shown that the body of the patient is a significant shift of, namely, the simulta-neous interventions. With professionalism and experiences of operators, as well as highly skilled anesthetic and resuscitation provide simultaneous operations in gynecology and surgery through the classic and com-bined approaches can take its rightful place in the offices of the practice, as in compliance with the above conditions do not pose a great danger to patients and positively they perceive

  F Ganiev

  44-48

  82   23

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  The role of ray diagnosis in rheumatoid lungs The analysis of ray diagnosis in rheumatoid lungs. The radiographs(with the help of KXO-50, Toshi-ba, Japan) of patients’ thorax organsaged from 25 to 70 with RA, and CT (Sonratow, Silmens) of 2 mm sec-tion in chest among 10 patients with general disease have been done. In radiographs of R Apatients’ thorax organs the following radiographic changes have been identified: Among 75% patients with general disease increasing the size of lungs and deformation with focal shadows, among 14% patients pneumonia focus (pic-ture 1) and of them 11% pleurodiaphragmatic scar have been found. Conventional radiograph and CT check-ups of thorax organs are considered as a main method of ray diagnosis. However, incomplete acuteness of early diagnosis of radiographic method and low level of identifying pathological process weakens the diag-nostic importance of this method. Because of this, radiographs of RA patients’ thorax organs cannot identify the changes of lungs. Therefore, radiography and CT methods are not contradictory, but complete each other in identifying morphological changes

  Ya Ahmedov, G Mardieva, G Aitimova

  41-43

  128   29

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  Study of portional kidney function in yound children with nephropathy exchange genesos 121 children with pneumonia on dismetabolic nephroparthy background were investigated, and 20 children with pneumonia without urinary syndrome. It were performed following methods of kidney partial functions investigation of: glomerulus filtration, ammonia, acidity, osmotic quality of urine, daily metabo-lites screening (oxalates, urates, urine acid). In patients with pneumonia on dismetabolic nephroparthy back-ground were revealed significant alterations of kidney partial functions, structural and functional condition of erythrocytes membrane, increasing of peroxides lipid oxidation processes. For the purpose of correction children with pneumonia and renal pathology it was prescribed following treatment

  M Ahmedova, N Rasulova, X Abdullaev

  37-40

  135   37

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  Clinical and neyrophysiological analysis violation of cerebral circulation in women The article listed results analyzes EEG in 80 women, violation of cerebral circulation in state peace and emotional stress. The study of electroencephalographic parameters of cerebral blood flow in women, held in different groups at rest and emotional stress and evaluated by five type classification of Gyrmunskiy. Electroencephalographic types of research state cflmness and emotional stress among age groups have pati-ens with VCC (violation of cerebral circulation), lated patients in the second group the (average age), that there has been a high leved of anxiety in comparison with other age groups

  D Ahmedova, X Kulmirzaeva, N Yusupova, A Jurabekova

  32-36

  186   18

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  Influence of anaemia on biochemical indexes at chronic illness of buds for children To evaluate the effect of anemia on the course of chronic kidney disease in children, identifying the re-lationship between the level of hemoglobin, endocrine and renal excretory function. All the children are di-vided into two groups according to the level of hemoglobin at the time of admission: group 1 - the children with hemoglobin <110 g / L, 2 group - children with hemoglobin levels £ 110 g / l. All children common blood and urine tests were conducted, as well as fecal helminth eggs. In order to identify the impact of ane-mia on the anemia rate of progression, we selected a group of 65 people, who for the time of our study GFR was determined by 2-fold or more. Of these, 27 children at least once recorded anemia, and the remaining 38 children hemoglobin level corresponds to the age norm. Renal anemia is more common in children with a current active pathological process in the kidneys, leading to deformation chashechno- pelvis system, re-vealed the results of excretory urography. Renal anemia is associated mostly with clinical and laboratory changes typical of CKD and reduce its dependence on renal excretory function appears only in the later stag-es of the disease

  D Aslanova, B Yuldashev, F Abdurasulov, N Holova, N Akhmedzhanova

  29-31

  127   27

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  Efficiency of laparoscopic adheolisis in acute adhesive colon obstruction During the last century till today adhesive disease is one of the difficult problems of abdominal sur-gery and its developing in 2-15% of postoperative patients. The aim of this research is improvement of the results of surgical treatment of patients with acute adhesive intestinal obstruction by using laparoscopic ad-hesiolysis. Ultrasound examination should be performed to the patients who were operated before with lapa-rotomic access which may to find adhesive process. Ultrasound examination dates adhesive process to op-portunity suppose availability adhesive and determine volume of operation. Laparoscopic adhesiolysis re-duced the risk of developing recurrence of adhesive process of abdominal cavity and it’s mini invasive method which helps fast rehabilitation patients with acute adhesive intestinal obstruction

  Z Aslonov, S Baimakov, S Mamaradzhabov, Sh Boltaev, X Rasulov

  24-28

  102   29

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  The approaches of the improved complex neurosurgical treatment in patients with chronic subdural hematomas and hygromas The article presents the results of surgical treatment of 167 patients with post-traumatic chronic subdural hematomas and hygromas operated in Neurosurgery Department of the Clinic of Samarkand Medical Institute in the period 2003-2014. Identified early restoration of clinical and neurological deficits of patients after treatment with endolumbal ozone and nootrop insufflation in the postoperative period

  M Aliyev, A Mamadaliev, S Mamadaliev

  19-23

  49   23

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  Opportunities and prospects endosurgery closed injuries of the abdomen during severe concomitant injury in children This article describes the clinical features and treatment strategy grounded in combined injury with closed abdominal injury in children with the use of new technology. Thanks to minimally invasive interven-tions can be avoided endosurgical conservative expectant management of patients with active surgical tactics regardless of the duration of the disease, reducing the risk of postoperative complications

  X Akilov, F Primov

  15-18

  78   33

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