No. 3 (96) (2017): Problems of biology and medicine

Morphological properties of 93 chopped-up skin wounds were studied. It is established that the wounds, depending on their location, have various forms. Wounds located along the Langer line have a linear, and an oblong form across the Langer lines. In addition, a different shape of the shoe section is found, depending on the localization and the immersion force

Purpose. The study of cellular and humoral immunity in premature infants. Material and methods. 90 premature babies born on the gestational age of 28-37 weeks. Methods of research are immunological, statisti-cal. Results. The state of the immune system in premature infants depends directly on the gestational age. The shorter the gestation period, the more pronounced manifestations of the decrease in the links of the immune status. Conclusion. Deficiency of immunoglobulin A is due to the immaturity of the undernourished child, but also the direct effect of its action on the sub-gastric gland

There are analysed results of surgical treatment of 115 patients with purulent-nekcrotic defeats of bot-tom finitenesses on the background of diabetes mellitus with signs of critical ischemia of bottom finitenesses. The comparative analysis of results of complex treatment has shown, application of Perphtoranum accelerates terms of clarification of wounds from infection for 4-5 days and creates pathological-genetical favorable condi-tions for reduction of quantity of progressing of purulent-necrotic processes of the bottom finitenesses that in its turn leads to reduction of number of the compelled high amputations from 36 % to 12 % and lethality from 15,78 % to 5,17 %, thus average duration of treatment is reduced from 19,5±3,5 days up to 12.5±1.5 days

The work was carried out examination and treatment of 30 patients with systemic lupus erythematosus (SLE). All patients underwent synchronous intensive therapy (SIT), which included a three-fold plasmapheresis (PF) with removal of 40-60 ml of plasma per kg of patient weight at intervals of 4-5 days. After each PF intra-venously over 45 minutes was administered 1.0 MP, and after the second - more added 1.0 cyclophosphamide. The dose of oral prednisolone should not exceed 40 mg / day. In the second phase was introduced on a monthly basis only 1.0 cyclophosphamide. Significantly decreased the frequency of erythema in the form of "butterfly", stomatitis, cheilitis enantemy and lupus, edema syndrome. Completely regressed pulmonary process, fever, lymphadenopathy, stabilized body weight, less defined polyserositis, arthritis

The achieved results confirm a high pain-relieving efficacy of percutaneous vertebroplasty. A choice of vertebroplasy technique depends on a nature of pathology and peculiarities of vertebral anatomy. Application of cement based on calcium phosphate, bioceramic and bonemorphogenetic proteins improves the long-term outcomes of percutaneous vertebroplasty

The studies included reported data and medical history of children who received treatment in the chil-dren's department of the Samarkand regional TB clinic. The results indicate that morbidity in Taylak exceeds the regional indices by at least 2 times. Almost half of all patients were in the age 7-10 years. Contact with tu-berculosis patients is the most significant risk factors in the development of primary TB infection. High morbid-ity of children from the family contact. About half of affected children suffered from catarrhal diseases, which also can be attributed to the long and often ill children at risk for the development of active forms of primary
tuberculosis.

Results of researches of 40 patients with NFDL are presented in article. It is shown that NFDL occurs as decrease in development by hepatocytes of primary holevy acid, and increase in its fecal excretion. Inclusion of a lignin enterosorbent in complex therapy of patients with NFDL normalizes a range primary and secondary AKh, restores the broken indicators of enterogepatical recirculation of AKh and an intestinal microbiocenosis

On today’s day in various clinics of the world apply various methods of operative treatment at traumas duodenun guts. However to сир a time is not present accurate indications to a certain method of diagnostics and operative treatment of traumas duodenun a gut that speaks about an urgency of this problem. In article the diagnostic test offered by authors for revealing of traumas duodenun is resulted and are described tactics of operative intervention

The work is based on the analysis of the results of examination and treatment of 538658 patients (1,077,316 joints) for the period from 2006 to 2016. Children from the first month of life to 1 year were ob-served in the polyclinic department of pediatric orthopedics. The patients were divided into 3 age groups, tak-ing into account the timing of the diagnosis and taking them into account. Thus, the analysis of long-term re-sults after the closed repositioning of congenital dislocation of the hip in one year and 5 years in three age groups showed that in 89% of cases, good clinical and radiologic indices in children in the group from 1 to 3 months were observed

In order to increase the effectiveness of the ultrasound method in diagnosing acute appendicitis, identify-ing the forms of acute process, taking into account the combined use of B-mode and the color Doppler mapping regimens, 20 boys and 34 girls aged 1 to 18 years with a clinical picture, suspicious on acute appendicitis

During pregnancy, jaundice syndrome can develop as a complication of pregnancy, as well as in infectious and other pathological conditions. Timely establishment of the correct diagnosis in the development of jaundice in pregnant women is extremely important, since the management of pregnant women with viral hepatitis and women with jaundice due to pregnancy pathologies has significant differences. The development of jaundice in pregnancy can lead to such pathological conditions as indomitable vomiting of pregnant women, cholestatic hepatosis of pregnant women. The most important and difficult is the differential diagnosis of acute fatty hepatosis of pregnant women. Acute fatty liver of pregnancy is a rare
occurring pathology of pregnancy: one case of acute fatty hepatosis of pregnant women occurs in 10,000-13,000 births. Consequently, in most maternity hospitals with the number of births of 3000-5000 per year, doctors theoretically have the opportunity to observe such a pathology of pregnant women once every three to four years [1,2]. As a rule, patients with AFGB are admitted to the infectious diseases hospital with suspicion of viral hepatitis, so the differential diagnosis is first of all, it is carried out with acute viral hepatitis (AVH) of various etiologies.

The established capability of nanoparticles to enhance the transport of chemicals and drugs into cells and through the barriers of the body makes the possibility of potentiating the toxic effects of chemical contami-nants when introducing into the body together with nanoparticles an urgent matter. In neutrophils of blood by means of cytophluorimetric method, the formation of active forms of oxygen was determined using dichloroflu-orescein diacetate, the intensity of apoptosis and necrosis – by the level of cells labeled with annexin V and propidium iodide, and also the number of cells with reduced mitochondrial transmembrane potential was eval-uated. Maximal changes in all indices were verified in the group of animals administered with SiO 2 nanoparti-cles and lead acetate. In this case, the active forms of oxygen output and the level of apoptotic and necrotic al-tered blood neutrophils of animals and the number of cells with decreased mitochondrial transmembrane po-tential increased significantly in the animals administered with nanoparticles and lead acetate compared to the animals administered with the toxicant only. The conclusion has been drawn that silicone dioxide nanoparticles enhance the capability of lead acetate to increase the production of intracellular active forms of oxygen, the level of apoptotic and necrotic altered blood neutrophils, and the number of cells with decreased mitochondrial transmembrane potential

Surgical treatment of congenital dislocation of the hip in the late period, especially in older children and adolescents, with high standing of the femoral head and secondary changes of elements of the hip joint, and also the muscles surrounding it is a difficult and not solved the problem. Objective: Based on the study results exist, methods of surgical interventions aimed at restoring the supporting ability of the limb in congenital dis-location of the hip in older children and adolescents, the most effective options work out operational interven-tions in this group of patients depending on the severity of hip dislocation and implement them in practical medicine. Material and Methods: The study is based on a survey and study of the results of surgical treatment of 70 patients’ older children and adolescents with unilateral congenital hip dislocation. To study the results of treatment have been used clinical, radiological and statistical methods. Results: The results of treatment were followed in the period from 1 to 6 years. Positive results were re-ceived in 82% of patients

Neurohistological methods of investigation have been used to study the intramural nervous apparatus of the common bile duct wall. An abundance of nerve elements in the wall of the common bile duct is established. Nerve nodes, nerve cells and receptors are found. The main number of receptors is concentrated in the terminal section of the common bile duct, that is, at the site of opening the ampule of the faters papilla in the gut

The intoxication of rats with tobacco smoke triggers the activation of free radical processes, in particu-lar lipoperoxidation, which is confirmed by an increase in the content of TBA-active products in the blood se-rum, liver, lungs and myocardium of rats after injury. The use of sodium nitrite as an additional toxicant deep-ens the activity of lipid peroxidation processes, to which older animals are more sensitive. It was noted that in the conditions of poisoning of rats with both toxicants, the activity of succinate dehydrogenase and cytochrome oxidase in the liver, lungs and myocardium is suppressed, which indicates a decrease in the activity of energy supply processes. The most pronounced decrease in the activity of these enzymes was observed in immature animals 72 hours after sodium nitrite entered the body against a background of 30-day intoxication with tobac-co smoke.

The results of toxicometric studies, which allowed to determine the toxicity parameters (LD 16 , LD 50 , LD 84 , LD 99 ) and hazard (absolute toxicity, acute toxic effect zone, tilt function, total and integral toxicity index) of germanium, magnesium and tartaric acid coordination compound (OKAGERM–4) for warm-blooded, in-cluding for humans. The data obtained make it possible to classify the compound as a group of low-toxic sub-stances (class IV) under conditions of intraperitoneal administration, which is the experimental basis for fur-ther, more in-depth studies of OKAGERM–4 as a therapeutic and prophylactic agent for correcting hypoxic syndrome

It was investigated in the dynamics the development of necrotic and proliferate processes in the adrena-line-calcium models of heart injury in rats. It is accompanied by oxidative, carbonyl, nitrooxidative stress, in-creased oxidative modification of proteins and changes in antioxidant defense. Maximal increase of oxidative modification of protein products observed after 3 days, the nitrite anion – after 3 and 14 days, diene, triene conjugate and Schiff-base – after 7 days, TBA-active products – after 14 days. Antioxidant protection of the heart muscle increases significantly in the development of adrenaline and calcium models of heart damage and its individual links peak at different periods of research: activity of catalase – after 3 days, ceruloplasmin con-centration and peroxidase activity of blood – after 14 days, superoxide dismutase activity – after 21 days. The values of the glutathione system in all periods of the study are decreased

In modern obstetrics, the issues of prevention and treatment of bleeding in obstetric practice are especially relevant. As noted by M.A. Omarov (2016), by the way this problem is solved, one can safely judge the qualifications of medical professionals.
Qing personnel and organization of emergency care in a particular obstetric institution. Obstetric bleeding is one of the leading causes of maternal mortality, accounting for 20-25% in its pure form, as a
the leading cause is 42%, and as a background cause, up to 78% [8].

Throughout the whole era of the development of surgery, an important motto was: "Big surgeon - big cut." This principle was indeed justified until some time. However, this approach to the implementation of the surgical approach was accompanied by a significant number of complications in the postoperative period associated with the intersection of powerful muscle layers, large main vessels and nerves. With the development of innovative medical technologies, the appearance of new instruments in the arsenal of surgeons, a more thorough preoperative examination of patients, the need to perform large incisions gradually disappeared. The most rapid development of medical technologies occurred in the 70-80s of the last century. A significant turning point in endoscopic surgery occurred in the late 80s, when a new operation was introduced into clinical practice - laparoscopic cholecystectomy (LC) (E. Muhe, 1985; Ph. Mouret, 1987). Currently, along with traditional cholecystectomy (TCE), LCE and minilaparotomic cholecystectomy (MCE) are widely used in clinical practice. The study of immediate and long-term results of treatment, which followed the introduction of new technologies into wide surgical practice, showed that the course of the postoperative period is largely associated not so much with the volume of surgical action directly in the abdominal cavity, but with the localization and size of the surgical wound [1 -3]. The end result of all options for cholecystectomy is the removal of the gallbladder, thus, the comparison of traumatic ™ minimally invasive and traditional interventions is essentially a comparison of the surgical approach and, to a lesser extent, certain technical features (for example, carboxyperitoneum, electrocoagulation, etc. ).

Vitamin D deficiency and its impact on the human body. Modern data on the effect of vitamin D deficiency on the human body are attracting more and more attention from researchers. The significance of this vitamin and its metabolites lies not only in its participation in the formation of the skeletal system, but also in other metabolic processes.

The effectiveness of ART programs in terms of pregnancy rate per embryo transfer is on average 35-40% in leading domestic and foreign clinics (RAHR - 2006, EBNEB - 2004). Assisted reproductive technologies (ART) include: - carrying an embryo by a female volunteer (“surrogate” motherhood) for the subsequent transfer of the child (children) to genetic parents; - donation of oocytes and embryos; - ixi; - cryoconservation of oocytes and embryos; - preimplantation diagnosis of hereditary diseases; - reduction of embryos in multiple pregnancies; - actually IVF and PE.

One of the main tasks of modern gynecology is the study of various aspects of the pathogenesis of benign proliferative processes of the endometrium. Improving the complex of diagnostic and therapeutic measures is possible on the basis of new knowledge about the mechanisms of development of the considered pathology. Against the backdrop of intensive scientific research over the past four decades, there has been a noticeable lag in the diagnosis and treatment of these diseases [1].

The rights of authors, inventors and innovators are protected by law [5,13,14,20]. One of the objects of legal protection is the discovery - the establishment of previously unknown objectively existing patterns, properties and phenomena of the material world, introducing fundamental changes in the level of knowledge. The state registration and legal protection provided for by the “Regulations” do not apply to discoveries of mineral deposits, as well as to geographical, archaeological, paleontological, i.e., discoveries that have the character of expeditionary finds. State registration is also not subject to discoveries in the field of social sciences [9,10]. The object of legal protection is an invention - a new technical solution of a problem with significant differences in any area of ​​the national economy, social and cultural construction or defense of the country, which gives a positive effect [10,11,17]. Rationalization proposal - a technical solution , which is new and useful for the enterprise, organization or institution to which it is submitted, and provides for a change in the design of products, production technology and applied equipment or a change in the composition of materials [19]

The decisive role for the emergence of MALT ("mucosa-associated lymphoid tissue" - lymphoid tissue associated with the mucous membranes) of gastric lymphoma is the role of stimulation of anthigen of local im-munity in the presence of Helicobacter pylori infection. For retrospective study, 83 patients with MALT diag-nosis of gastric lymphoma were taken in the treatment of the Republican Cancer Research Center and Tashkent City Oncology Dispensary. The diagnosis of all patients was confirmed histologically

Concerning a fracture of a neck of a femur 65 patients in particular have been operated total endopros-thesis replacement of a joint is carried out. Under our observation there were 65 patients who have executed primary endoprosthesis replacement of a coxofemoral joint concerning femur neck fractures. Among treated 28 - 60 years (43%) are more senior. The most elderly patient was 84 years old. – 22 (33.8%), 80 years – 2 pa-tients – 3% are also more senior than patients from 40 to 50 years. Feature of the early postoperative period was the fact that the patients operated after 3 days from the moment of receipt, much more difficult also are longer the patients operated within the first 3 days adapted to walking on crutches and to service of, than. Good results are received at 86% of the operated patients. The endoprosthesis replacement of a coxofemoral joint executed in early terms (it is optimum within the first week after a change), allows to make active victims, to reduce quantity of postoperative complications, a lethality and to adapt patients to independent and active life for rather long period.

Treatment of children with fractures of bones of a forearm is an urgent and complex problem. The analy-sis of treatment of the closed fractures of bones of a forearm at 118 patients is made. The patient has applied conservative treatment (a one-stage manual repozition and an immobilization with plaster steak) and expedi-tious treatment (an open repozition, an intramedullary osteosynthesis and an immobilization with plaster steak) methods. Renewal of working capacity has happened in 71,4% of cases. It has become possible thanks to a combination of terms of treatment to the rehabilitation period, and also use improved a method of expeditious treatment. The correct comparison of bone fracture, their reliable fixing, early adequate functional loading is the main principles of treatment of fractures of forearm. Studying results of clinical application of a way a one-stage manual repozition and an intramedullary osteosynthesis of fractures of bones of a forearm at children is given in article. Studied and improved ways treatment provides increase in rigidity of fixing of bone fragments, prevents deformation, promotes to successful result.

Materials and methods: 158 male patients with DM type 2 men Uzbek population have been surveyed. Results: Analysis of the research showed that the allele C gene TGFβ1 occurs much less frequently than allele G in both healthy individuals (3,2%), and in patients with type 2 DM of (8,2%). CC genotype frequency of equally high and (93,5%) in healthy patients and DM (84,8; p=0,31%). No significant differences in genotype frequency of CG in healthy subjects and 6,5% of patients with type 2 DM (13,9%). Homozygous GG genotype in healthy men was not present. Conclusion: Except for lack GG genotype among researched healthy men and patients with type 2 DM of Uzbek population no significant difference was defected neither in allele, nor in rep-resentation of genotypes G915C polymorphism gene TGFβ1

The article considers the spectra of anti- and proinflammatory cytokines in blood serum at the family bronchial asthma, as well as the nature of clinical and pathogenic forms of bronchial asthma, which affect the formation of the disease. The study was conducted in 346 relatives from 49 families with bronchial asthma. It
was determined in the serum of IL-6 and γ-interferon that the "Vector-Best" test was used. A study was made of the number of IL-6 and γ-interferon in the blood serum in patients with familial bronchial asthma, depending on the pathogenetic forms, stages, length of service and the degree of disease control. It was found that an in-
crease in the number of IL-6 in the blood serum, a decrease in interferon-γ depending on the stage, allergic forms, an increase in the length of the disease and in patients with uncontrolled asthma are a differential diag-nostic marker.

We analyzed long-term results of patency of the fallopian tubes according to metrosalpingography data in different variants of conducting an ectopic pregnancy. The data showed that in women who underwent con-servative treatment with cytostatic, the patency of the fallopian tubes was significantly better than after surgical treatment. In cases of interrupted ectopic pregnancy for which laparotomy was applied with the removal of the motor tube, infertility of tubal peritoneal genesis developed in 60 % of cases, which coincides with the opinion of many authors

The condition of the ovarian reserve in endometrioid cysts of the ovaries depends to a large extent on the volume and frequency of the surgical intervention. The results of the hormonal study suggest that the most sen-sitive to intraoperative damage and an indicative marker of the ovarian reserve is the antimuller hormone in combination with the determination of the CA-125 content and the concentration of follicle-stimulating hor-mone. The results of the performed surgical intervention in a sparing amount allow us to predict the restoration of fertility after surgical treatment with the maximum preservation of healthy tissue, which allows preserving the reserve of ovaries and the reproductive health of women

The results of complex therapy in 65 pregnant women with placental dysfunction are analyzed. The con-trol group consisted of 30 women with a physiological pregnancy. The main group consisted of 65 pregnant women in the gestation period of 32-36 weeks, in whom placental dysfunction was diagnosed as a result of ul-trasonic screening. The inclusion of levocarnitine and L-arginine in therapy with placental dysfunction can effectively stabilize the functional state of the fetus and prolong the prolongation of pregnancy

The comparative quantitative assessment risk factors of rapid development of alcoholism are scrutinized in the article. 140 alcoholic patients aged 25-65 years have been studied by Clinical-statistic method. Univari-ate depression analysis with the usage of Kraskola-Uolis criteria was used for comparison with medieval clinic significance, age-specific and dynamical parameters. While carrying out the research the author has revealed that early formation of alcoholic dependence is not associated with the age onset of alcohol consumption but mainly risk factors in premorbid. The results of the research showed that the dynamics alcoholism development is important to evaluate the clinical severity, the flow rate and development of optimal tactics of treatment. The presence of premorbid cofactors risk increases the development of alcoholism as quickly as 2,5 times compared to uncomplicated premorbid. In conclusion, the author draws a conclusion that quantitive dynamic develop-ment characteristics of the disease will be fairly objective criteria to predict the clinical versions and types of alcohol flow.

In the Samarkand city medical association in the department of thoraco-abdominal surgery in 2013-2016, 68 patients were hospitalized for postoperative ventral hernia. Of them, alloplasty was performed in 44 patients on the anterior abdominal wall by the "onlay" method, and the remaining 24 patients underwent alloplasty of the anterior Of the abdominal wall by the method of "sublay", about large and giant hernias. Among these alloplastics, the following complications were observed using the "onlay" method: recurrence of hernias, accumulation of subcutaneous seromy. In alloplasty by the method of "s Ublay "these complications were not observed, and the postoperative rehabilitation period was reduced. The obtained results show that, according to the" sublay "method, alloplasty is considered to be the most effective method for large and giant hernias

The study group is 767 patients who had been treated at the Proctology department of SamMI clinic №1 between the period from 2001 to 2016 years among which 36(4,7%) patients had necrotic form of the disease. In 731 (95.3%) aerobic etiology of damage was found. The average age of the patients was 63,1±4,9 years old. Clinical checkup, digital investigation of the rectum and rectoromanoscopy, transabdominal and transrectal ultrasound, CT and bacteriological investigation of wound’s discharges were done in all the patients. All the surgeries were performed urgently. Results of the studies showed that early diagnosis and radical operation with additional antibacterial and detox therapy led to recovery

The purpose of the work to study of the molecular and biological markers in the ovarian and cervix can-cer as choice criteria methods such a extracorporal immunofarmakotherapy (EIFT) among the complex treat-ment. To study level of tumor markers was shown that the greatest predictive importance for treatment efficien-cy such markers as p53, VEGF and Ki-67, and level of tumor proliferative activity. The greatest effect obtained when carrying out an accompanying immunotherapy with EIFT and plasma exchange

Purpose: carry out analysis of the morbidity frequency of epilepsy and its prevalence according to the age and gender in rural districts of Samarkand region. Materials and methods: objects of research has served the territory of four rural districts of Samarkand region, which determined the incidence and prevalence of epi-lepsy. Results: Analysis of the morbidity of epilepsy in this population showed that the annual rate of total mor-bidity was higher than the indices of the previous years, designed on the basis of anamnesis. Conclusions: analysis of the prevalence of epilepsy according to the age showed a gradual increase of infestation of epilepsy in the middle age groups, with a peak in the group of 44-60 years and a gradual reduction from the sixth dec-ade

Study the features of pregnant women with a history-governmental reproductive loss in history enable the development of proposals to improve the medical care of mother and child directed lennye to prevent re-productive losses

The syndrome of enlarged mediastinum is a symptom complex characterized by certain signs of diseases and conditions accompanied by an increase of the mediastinum organs. The most significant nosological units in children are carditis, cardiomyopathy, congenital heart defects, thymomegalia. Rapid determination of the nature of the disease, radiologically characterized by enlarged mediastinum, is important in urgent conditions. Timely determination of such indices as cardiothoracic, cardiothymicotorakal and vaso-cardial according to a survey X-ray diffraction can be considered an accessible method of differential diagno-sis in infants with acute conditions

Treatment of iron-deficiency anemia is carried out according to the etiopathogenetic condition. If possi-ble, the causes of the disease are eliminated by an etiological factor that promotes the development of anemia. Pathogenetic method of cure is the appointment of iron preparations. In this work, characteristic of the medi-cine "Hemolif" is given, which was used in 30 patients who were on cured at the Research Institute of Hema-tology and Blood transfusion with the iron-deficiency anemia diagnosis in heavy degree. The positive effect of the Hemolif action is due to the iron (III) content of the hydroxide of the sucrose complex, stimulates erythro-poiesis and leads to an increase in the hemoglobin level

Results of surgical treatment of 13 patients with scrotum gangrene (Furnie’s disease) admitted to the proctology department of the 1st SamMI Clinic are observed in the article. The early diagnostics and active management are used for radical surgical treatment of the purulent necrotic focus in combination with ne-crectomy in step-by-step maneuver. Complex system of the local treatment of the wound, purposeful and multi-ple component correction of systemic and metabolic disorders of the homeostasis are the real way to improve treatment results

Applying antihistamine in complex therapy exudative otitis media with an allergic rhinitis antilecotreins and topic intranasalglucocorticosteroids has show them to b reliable clinic effect which degenerated in the de-velopment of hearing decreasing symptoms and improving life style. Under our supervision there were 67 chil-dren with exudative otitis media by age from 3 to 18 year , 39 from them wereboys, and 28 were girl. Using in complex therapy with exudative otitis media with an allergic rhinitis intranasal glucocorticosteroid showing highly clinic effect, which shows reliable mucociliar transport function mucous membrane

Summary: In recent years the possibility of isolating groups of free radical pathologies. High sensivity of test reflecting the metabolic reaction of the membrane level in chronic sinusitis that’s explains the composition of cell membranes and obtain more information for assessing the severity of pathologic process. There were showing and treating 48children at age from 5 to 15 with an exacerbation of various forms chronic sinusitis. Applying of drug aktovegen shows not only therapeutics effect but proof his antioxidant effect which show how relapse are down after applying therapy it make possibility for recommendation necessary in complex therapy

The study includes data from clinical and neurological examinations of 31 patients (18 women, 13 men), whose average age was 30 years with tumors localized in 18 (58,0%) patients in left, 13 (42,0%) patients in the right hemisphere of the cerebellum. For tumors of the hemispheres of the cerebellum characteristic was the presence of general cerebral and focal symptoms. Among the cerebral symptoms were observed headache (77,4%), vomiting (67,7%) and dizziness (35,4 %), of focal disorders - dysfunction of the cranial nerves (80,0%), dominated oculomotory disorders (37,2%), indicating the progression of the compression of brain-stem.

Now the basic principles of surgical treatment of spinal fractures are the most quickly and effective recovery of anatomic relationship, rigid bracing of the damaged segment and early activation of the victim. 34 patients with the fractures which aren't complicated compression complete burst the lower thoracic and lumbar of vertebrae were investigated. 11 patients have a preoperative reposition of the compressed vertebra with anatomic height and corrections of a posttraumatic kyphosis of a spine column with use of the device "Pardayev-Urinbayev" (patent RF №2033775), the subsequent use by transpedicular system bracing for stabilization of vertebrae. Thus, the preoperative reposition with the Pardayev-Urinbayev device reduces duration of operation and use of TPF, reduces hemorrhages and increases showiness of operation

The study involved 95 teenagers with epileptic paroxysms. The study included 48 children (22 boys and 26 girls) aged between 12 and 17 years with various forms of epilepsy. All of the patients underwent clinical and instrumental methods of electroencephalography, magnetic resonance imaging and examined hormones in the blood. Survey assessment showed that epileptiform EEG changes on MRI brain structural changes identi-fied in the majority of cases. Results of the study of hormones in the blood indicate a complex interaction be-tween the endocrine and nervous systems in epilepsy in adolescents

58 patients with acute coronary syndrome with asymptomatic hyperuricemia were examined. The results of the study showed that ACS is accompanied by an increase in the level of uric acid in the blood, which tends to decrease during the recovery of circulation in the ischemic myocardium, which characterizes the significant activation of the enzyme xanthine oxidase, which generates active forms of oxygen