No. 4(91) (2016): Problems of biology and medicine

It is known that women of childbearing period, unlike men, have a low risk of cardiovascular events [20]. However, after the onset of menopause, the likelihood of developing CVD, including coronary artery disease, increases significantly [4, 13, 18], comparing and sometimes exceeding that in men in the future.

Phytotherapy with herb of harmala was carried out in 19 patients aged 8 to 15 years with chronic gen-eralized catarrhal gingivitis. The preparation was applied daily for 20 minutes in a 1% of hydrous solution for applications. 89.5% of examined patients were diagnosed chronic generalized catarrhal gingivitis in periodon-tal index (PI), equal to 1.8. Over 1/3 examined patients were diagnosed mild and severe form of the disease. It is found that in the absence of inflammation the value of elektrobiopotentsials is an average of 1.3 mV, in gin-givitisitis it increases in 2 times. Judging by the reliable reduction of PI and GI and the improvement of perio-dontal microcirculation 1% of hydrous extract of the herb of harmala has a marked anti-inflammatory effect and can be used in the treatment of gingivitis.

There were chosen 60 people with light and moderate gingivitis and halitosis, and 13 people with no so-matic diseases from 96 examined people. We carried out not only traditional methods of treatment, profession-al cleaning with ultrasonic scaler and applied to patients swilling with “Fresco” and to clean with “Dentagum Fito”. Using antihalitosis agents of hygiene in patients with general chronic catarrhal gingivitis reduces hali-tosis heaviness degree

Formation of industrial zones, as a part of which is acted the most harmful oil refineries and chemical production, leading to massive air pollution with toxic emissions are often complex and multi-component composition. In this paper we presented the hygiene requirements which must be require in the design, construction and reconstruction of refineries and chemical industry as part of an industrial complex

It was carried out complex analysis of the discharge of purulent wounds and bacteriological methods of GLC. It was found that small number of strains were presented by asporogenous anaerobic bacteria (34.6%), which prevailed over the facultative-anaerobic, aerobic forms and fungi (22.7%) during bacteriological exami-nation. In normergic type of inflammatory reaction microbial associations were often presented by 4-6 species of microorganisms (61.3%),in hypergic type to 6-8 species (90.3%), in hyperergic type of 3-4 species. When GLC method of investigation in the test samples prevailed: Enterococcus, Lactobacillus, Streptococcus, Clos-tridium, Actinomyces,Corynebacterium, Bacteroides, Nocardiopsis, Nocardia, Propionibacterium jensenii, Streptococcus thermophilus, St. salivarius, St. mutans, other species of microorganisms occurred in smaller numbers. GLC method is more informative and on expressiveness exceeds microbiological method.

The aim was to study the relationship between the morphological parameters of vertebral column and indexes of girl’ healthy on their physical development at preschool age that are residing in the Bukhara city. It was found a direct relation between the morphological parameters of the vertebra and indexes of physical de-velopment of healthy girls. It was identified the length’ parameters of the vertebral column and parameters of vertebra’ parts that can be recommended as indicators of the normal physical development for girl. These stud-ied indexes can be also recommending for early determination of vertebra’abnormalities of healthy posture of girl at pre-school age

It was carried out a comprehensive survey of 98 patients with chronic non-specific pain in the lower back. It is shown that the combined use of anti-inflammatory drugs together with B vitamins can reduce the dose of NSAIDs to reduce the time and the reduction of pain.

Has been made check up of 1432 newborn children. The positive sign of Marx-Ortolani is established in 5,1%, weakness (looseness) of a hip joint - in 2,9%, limited abduction – in 17,8%. a X-ray analysis of a hip joint carried out in 1142 children and have been established a normal find hy in 63,1% from them. Displaziya is found in 18,3%, under dislocation - in 7,3%, dislocation 10,6%. The radiological picture of a hip joint not always corresponds to an initial clinical find hys. The number of cases late patologik relatively are a lot of.

The peculiarities of anti-apoptotic mechanisms in the nerve and glial cells of the temporal lobe cortex are studied by the changes of location of Bcl-2 + -cells and concentration and content of Bcl-2protein in them in rats with diabetes mellitus in the dynamics of ischemic-reperfusion injury of the brain. Anti-apoptotic potential was found to be intensified in the early port-ischemic period in the nerve and mostly in glial cells of the tem-poral lobe cortex at the expense of increased amount of Bcl-2 + -cells and concentration of Bcl-2 protein in them. In the late post-ischemic period the activity of anti-apoptotic processe in the nerve cells remains elevated, and in the glial cells it is reduced a bit by means of decreased density of Bcl-2 protein. Three-month strepto-zotocin-induced diabetes does not affect on the expression of Bcl-2 protein in the nerve and glial cells of the cerebral temporal lobe cortex. 20 minute ischemia with 1 hour reperfusion was found to intensify anti-apoptotic potential in the nerve and glial cells of the cerebral temporal lobe cortex in animals with diabetes mellitus at the expense of both increased amount of Bcl-2 + -cells and concentration of Bcl-2 protein in them.On the 12 th day of ischemic-reperfusion period in rats with carbohydrate metabolic disorders the intensity of anti-apoptotic mechanisms in the nerve cells remains high, and in the glial ones – on the level of the control group of animals.

Neurohistological methods found polyvalent receptors in the wall of various designs biliary systems. The concentration of receptor structures of the highest in the end of the common bile duct, including vials of fater papilla. In this area the receptors overlap each other and form the receptor field. The basic amount of receptor sites associated with spinal 7-8 thoracic segments of the spinal cord.

Due to the rapid development of nanotechnology in the last decade, it is now an urgent need to under-stand the toxicological properties of nanoparticles ingested together with chemicals. The aim of this study was to investigate the ability of fullerenes C60 and chemical toxicant toluene to cause changes in the state of hu-moral immune system and cytokine profile. A significant increase in the concentration of immunoglobulin G, circulating immune complexes, pro-inflammatory cytokines TNF-α, IL-1β, IL-6 as well as a decrease in anti-inflammatory IL-4 and IL-10 in the serum of rats which were injected intraperitoneally with toluene were found. Changes in humoral immunity and imbalance between pro- and anti-inflammatory cytokines were signif-icantly more pronounced in animals treated with toluene together with fullerenes. It has been concluded that
that carbon nanoparticles fullerenes C60 potentiate toxic effects of chemical toxicant toluene on the humoral immunity and cytokine profile.

The mucous wall of the ampule of Vater papilla person forms the high-rise plicae in proximal-distal di-rection. The free end of distal plicae closes beside orifice of the ampule, forming special device. It is precluding retrograde arrival of the contents of the gut in ampule. Introduction endoscopic probe in retrograde direction can bring about to traumatize this complex or unscrew these plicae. Possible that some complications retro-grade endoscopic manipulate are connected with this effect

The aim of study was to assess importance of bacteria crops from the inner organs of laboratory animals during the experimental small and large intenstines mouse obstruction. It was found that due to small intestines obstruction there were the crops of the gram-negative bacils, gram- positive kokks and anaerobs. The ability of translocation of anaerobes was very low. It is found that translacation ability of microorganisms was not de-pended on time of obturation. A significant difference in “crop rate” between Staphylococcus spp and and En-terococcus spp. in the large intestines obstruction in dependence of small intestine obstruction suggested to use as the main microbiological criteria.

Cushing’s syndrome (CS) is a severe neuroendocrine disorder caused by chronic hyperproduction of adrenocorticotrophic hormone (ACTH) by a tumor in the pituitary. There are four forms of the syndrome, to name ACTH-dependent, ACTH-independent, corticoliberin ectopated and yatrogenic one. The article presents data of CS register in the Fergana region. Analysis of the data demonstrated low rate of both CS diagnosing (0.4 per 100,100 of population) and mortality (0.02 per 100,000 of population).

In the structure of malignant neoplasms in women in Uzbekistan, cervical cancer ranks second after breast cancer (BC), while its share is 12.49%. Standardized incidence rate
CC in the republic in 2015 amounted to 5.5 per 100 thousand of the world population. The highest incidence of cervical cancer is characteristic at the age of 45-64 years, at the age of 0-19 years it practically does not occur (0.066%), the peak incidence occurs at 45-64 years, more than 28% of women fall ill before 44 years of age, while the average age falls on women 53 years old. Considering the statistical indicators of the incidence of cervical cancer, which tend to increase, the problem of studying this pathology from the point of view of oncoepidemiology, and also, the mechanisms of carcinogenesis is relevant and in demand. HPV is one of the determining factors contributing to the development of cervical cancer. Every year, 470 thousand new cases of cervical cancer are registered in the world, which is 14.2% of all malignant neoplasms in women, more than half of which ends in death. HPV is one of the studied and most common infections that predetermine the development of this pathology - papillomavirus, which is diagnosed in more than 3 million people. cases [1, 2, 3].

Chronic heart failure (CHF) is the final stage of many cardiovascular diseases, characterized by morphological and functional disorders of the heart in response to damaging overloads and neuroendocrine influences. The observed increase in the number of patients with CHF in economically developed countries is associated primarily with an increase in the age of patients, as well as a significant improvement in care for patients with ischemia mimic heart disease and treatment of comorbid diseases. The prevalence of clinically pronounced CHF in the general population is at least 1.8-2.0%. In persons over 65 years of age, the frequency of CHF increases to 7-11%. However, CHF is the most common cause hospitalization of patients of this age, and the economic costs of its treatment increase many times [15].

Dental and maxillofacial anomalies occupy one of the first places among the diseases of the maxillofacial region and are characterized by significant morphological, functional and aesthetic disorders already in the early stages of bite formation. Most often there is a combination of sagittal and vertical anomalies of occlusion. Examination of the organs of the oral cavity plays a major role in identifying dental pathology, making a diagnosis, choosing a method of treatment and represents is an important part of the general examination of the body [2].

The problem of abdominal delivery is one of the topical scientific areas, since to date, caesarean section remains one of the main operations in modern obstetrics, helping the mother and child [24, 26]. Of particular relevance is the problem of choosing the optimal method of anesthesia in relation to women in labor with overweight and obesity, who constitute a group of increased risk for the development of life-threatening complications. An anesthesiologist working with parturient women and concomitant obesity may face the following problems:

According to the WHO, pneumococcal infection, the most common bacterial infection in humans, annually leads to the death of 1.6 million people, including from 0.7 to 1 million children, which is 40% of the death rate of children in the first 5 years life [1,2,9,11,12,14].

The most dangerous for a person are conditions in which serious disturbances occur in his body that he does not feel. In this case, treatment is not prescribed on time, which may increase the risk of death or serious complications. One of these conditions is painless myocardial ischemia. This means that the person does not feel pain, but the ECG shows signs of myocardial ischemia. For the first time, reports on this condition were provided by R. Wood in 1957, when among 100 patients examined by him in 26 patients, he found that changes in the electrocardiogram (ECG) were not accompanied by anginal pain. In the future, this phenomenon was called painless, or "silent" myocardial ischemia.

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology, characterized by hyperproduction of non-organ-specific autoantibodies to various components of cell poison with the development of immune-inflammatory damage to tissues and internal organs [1].

Burns are one of the most common types of injuries that can occur at home or at work, and are not only a medical but also a socio-economic problem.

In modern traumatology and orthopedics, great importance is attached to the pathology of large joints, in particular, the hip joint. In recent years, a significant increase in the indicators of damage to the osteoarticular system has been determined from 10.9 up to 16.9 per 100 thousand of the adult population. The proportion of diseases and injuries of the hip joint is 8.1%. According to WHO forecasts, the number of patients with this pathology will grow, which is associated with an increase in the average life expectancy of the population. An analysis of the literature showed that the traditional X-ray examination has not lost its significance at the present time. According to X-ray data, more than 80.0% of pathological changes in bones and joints are established, and in almost 70.0% of cases a correct interpretation is possible obtained data [7,12,14].

The issues of prevention of oncological diseases are becoming increasingly important every year. A new direction of chemopreventive therapy has been formed in oncology. Chemopreventive therapy involves the negative impact or blocking of any of the stages of carcinogenesis. Carcinogenesis is characterized It is caused by genetic changes that lead to disruption of the regulatory chains that control proliferation (growth), apoptosis, and cell differentiation. Prostate cancer (PCa) progresses slowly and is most often diagnosed in older men. Delaying the onset of the disease by several years will reduce the incidence, making PCa an ideal strategic target for chemoprevention.

Uzbekistan belongs to the regions endemic for severe and dangerous human helminthiasis echinococcosis [1,3]. The problem is particularly acute due to the significant socio-economic damage caused by echinococcosis to the national economy of the country, amounting to millions of soums per year. All this dictates the need to organize and conduct a wide front of complex medical, veterinary and communal measures to combat and prevent the incidence of echinococcosis among the high-risk group (shepherds, shepherds, cattlemen, calves, milkmaids, hunters, animal workers). farms, purveyors, children under 14, etc.) and inadmissibility of distribution among agricultural and wild herbivores, omnivores and carnivores. This is all the more relevant due to the fact that in a number of places not only the population, but also the medical, veterinary and municipal services do not sufficiently realize the problem of echinococcosis [2,4]

Use color Doppler ultrasound 88 patients with varicocele I, II and III degree, aged 16 to 35 years. Of these, 22 patients diagnosed with subclinical varicoceles. All patients with subclinical varicoceles was not a pathological enlargement grozdevidnoe plexus. For the diagnosis of subclinical varicoceles were determined the following parameters Doppler ultrasound: 1) the maximum diameter of the veins more than 3 mm; 2) the presence of more than 4 plexus of varicose veins; 3) change in blood velocity Valsalva maneuver from 2 cm / sec to 10 cm / sec and determining retrograde blood flow (reflux). In all groups of patients score with subclini-cal varicoceles were recruited mainly due to changes in blood flow rate under a load. While in a clinical vari-cocele score was recruited by the maximum diameter of the venous plexus and the amount of varicose veins.
This gives grounds to pave that grozdevidnoe plexus is only the tip of the iceberg, which does not give any idea of the true size of its violation of hemodynamics. Color Doppler ultrasound parameters make it possible to ac-curately diagnose subclinical varicocele, degree of pathological process and determination of the type of he-modynamic disturbances.

The paper presents the experience and results of early rehabilitation after subclavian-pulmonary artery anastomosis and tetralogy of Fallot repairs performed in RSCS named after acad. V.Vakhidov over a period of 40 years. The efficiency of regulated anastomosis application after Blalock-Taussig shunting was proved and the intensive care tactic in early postoperative period was optimized.

The article reveals consequences of diabetic neuropathy, its classification, describes methods for disease screening required for diagnosis. The use of screening methods is rapid (10,5 minutes), convenient and precise way to diagnose diabetic neuropathy in patients with diabetes. Precise and early diagnosis prevents the potential risk of disease progression and contributes to the timely treatment

High temperature hot days are one of the main reasons for serious coronary heart disease (CHD), diabe-tes, respiratory diseases and other accidents resulting in hospitalization. In coal-mining "Angren coal mine" having a depth of 150 meters were studied among 32 workers who have been working for over 12 years. Under conditions of limited air traffic flow in mines and heating the earth's surface, rising daytime temperatures (over 40 0 С) working zone air. Considering that the long average duration of hot days in Uzbekistan there is more than 100 days, works on a coal mining in conditions of high temperature, has a negative action on the health of workers, which is accompanied by a number of physiological changes in the body: activation sympathoadrenal system (increased heart rate, minute blowout of blood, a possible increase in arterial pressure), increased lev-els of sodium contributes to increased blood osmolarity that causes a strong of thirst and others

The work includes the clinical comparative analysis of ectopic pregnancy’s mortality cases caused by hemorrhagic shock and near miss. Current results contain morphological changes in the adenohypophysis which depend on the amount of hemorrhage and determine the direction of rehabilitation measures in a group of patients who experienced hemorrhage shock

A study of 85 children with epilepsy or without at cerebral palsy background to study the level of pro-inflammatory (TNF-α and IFN-γ) cytokines in the serum and cerebrospinal fluid. It was revealed that the pe-ripheral blood serum of children with cerebral palsy TNF-α level by almost 3 times higher than control group values, and IFN-γ level is 1.3 times lower than control values. In children with cerebral palsy with epilepsy on a background level of TNF-α is 1.5 times higher than the control group values, and 1.7 times lower than that of children with cerebral palsy without epilepsy, and the level of IFN-γ in the presence of epilepsy is 1.7 times lower control values. In the cerebrospinal fluid of children with cerebral palsy and epilepsy level of TNF-α was significantly higher than in children without epilepsy

The pilot areas (Muinak, Kungrad, Shumanay, Chimbay and Beruni) Nukus, the indicators of the objects evaluated environment, open water and tap water. Analysis of the research showed that in the assessment of environmental impact, in particular the water factors on the health of the population of Kazakhstan, one of the leading nozoform is a disease of kidney and ureter stones (KPiM). Determine the validity of the average direct correlation between indicators KPiM and chemical contamination of tap water. The incidence RK KPiM in northern and central zone associated with contaminated tap water in South zone - the water of open reservoirs

The authors identified a laboratory - neurosonographic regularities of the formation of various structur-al damage of the central nervous system, allowing to create a system of differential diagnosis of CNS lesions with intracranial hemorrhage and hypoxic - ischemic encephalopathy. For the first time the regularities of adaptive-compensatory reactions function of several organs in children in the first two months of life, depend-ing on the structural damage to the central nervous system were revealed.

A retrospective analysis of 912 cases of children with histories of BOS in age from 1 to 3 years for the period from 2012 to 2015. BOS has developed against the background of an acute obstructive bronchitis was diagnosed in 494 (54.2%) children group 1. In the comparison group, the diagnosis of acute bronchitis without the phenomena of bronchial obstruction was diagnosed in 418 (45.8%) group 2.There were an evaluated fac-tors of the risk in development BOS of the children

Questioning for 378 women from 50 to 80 years of age who are in menopause and live in Bukhara re-gion. The prevalence of osteoporosis among surveyed postmenopausal women living in Bukhara region com-prised 24.1%, osteopenia - 33.6%.With increase of age there the number of women with normal BMD signifi-
cantly declines (from 50.5% at age of 50-59 to 5,0% - at ≥70).Dairy products were regularly consumed by less than half of the women (43.7%) and 46.3% were physically active during at least 30 minutes daily. Early men-opause was significantly more common among women with osteoporosis (39.6%), than in women with nBMD
(20.6%). Irregular consumption of dairy products, low physical activity and the duration of menopause were the risk factors in the studied group of women

The studies conducted in 150 patients operated on for toxic goiter, before surgery and one year after thy-roidectomy. The severity of heart failure (HF) in patients with toxic goiter we studied in terms of six-minute walk test. Before surgery, 48 patients with thyrotoxicosis of average weight at 13, it regarded as HFI and 35 - both HFIIA. One year after the operation structure HF changed: in 5 patients it was not determined, in 21 cas-es was HFI and 22 patients - HFIIA. Among the 102 patients with severe hyperthyroidism, before surgery in 78 cases of HF was defined as HFIIA and 24 - HFIIB. After the operation, 19 cases were diagnosed HFI, 69 -HFIIA and 24 it has not changed.
In assessing the long-term results as the tests used change indicators severity of heart failure and cardi-ac arrhythmias, and divided them by the developed gradation, a good, satisfactory, unsatisfactory and ineffec-tive treatment. Good and satisfactory results in patients with thyrotoxicosis of average weight obtained in 47 (98.0%) patients and in patients with severe thyrotoxicosis - in 45 (44.1%). It concluded that long-term results of surgical treatment of patients with toxic goiter are directly dependent on the severity of hyperthyroidism, heart failure and heart rhythm disorders

To develop a method of modified set bronchophonography and set a diagnostic criteria of bronchial obstruction syndrome in young children. The study involved 60 patients with acute bronchiolitis and 60 healthy infants. We have developed the method of modified bronchophonography consisting of the registra-tion system of the respiratory noises and the personal computer. The analysis of respiratory noise was conduct-ed using the special software. Method of modified bronchophonography is important in the diagnosis of bron-chial obstruction syndrome in infants because of its objectivity, simplicity and accessibility of use in pediatric practice. New informative diagnostic criteria of bronchial obstruction syndrome in children has been estab-lished - E:I index, bronchial obstruction is diagnosed at E:I index≥1,20, bronchial obstruction is absent if E:I index≤1,19

Analysis of cytokine content depending on the amount organs involved in the pathological process -Authority 2, 3-4 body 4 more bodies cytokine TNFα level in sepsis increases regardless of the number of affect-ed organs, and its values are comparable with results in local infection, whereas anti-inflammatory cytokine IL-1Ra differences between groups of organ dysfunction: significantly increases as organ involvement in the pathological process. The ratio of IL-1Ra / TNFα with a 2-organ damage is not distinguishable from this figure at local infection, whereas the further involvement of authorities in the pathological process, rapidly increases

Summary of the first years of child in many aspect sare critical for language development, cognitive and social emotional skills, which leads to the paramount importance of early diagnosed hearing loss with problem which hearing. Factors such as, the age at which the of fense occured in the auditory the function, period de-tection of the degree hearing loss and time lines on meropryty to re-story auditory function.

The analysis of the prognostic significance of oncoprotein HER2/neu in 54 patients with rectal cancer with T3-4N0-1M0 stages of the disease. It has been shown that patients with relapsed disease, high expression of onkomarkers detected in 11.5% of cases, whereas in patients without relapses - in 3.5% of cases. At the same time, a small number of HER2/neu-positive primary adenocarcinoma of the rectum (15.0%) limits the prognos-tic significance of tumor marker for tumors of this localization. In order to develop effective models for the in-dividual prognosis of the disease, it is necessary to complete the use of various molecular markers that may contribute to a more accurate assessment of the potential of recurrent tumor

In the formation of mental disorders in HIV-infected patients using psychoactive substances (surfactants), undertaken to study the personal characteristics that influence the emergence and course of mental disorders. Studies show that the main factors in the formation of mental disorders in HIV-infected patients who use SAS is the individual personality

This article describes the features of the application of the method of psychodrama therapy for HIV-infected patients using psychoactive substances emerging mental disorders, and to enhance the development of interpersonal skills and adaptation in society. The use of this exposure helps improve mental state and improve the quality of life of patients, drug users with HIV infection.

The results of veloergometric researches carried on the CHD patients in different programs of physical rehabilitation are represented in this article. The indices of physical efficiency and physical activity tolerance of examined patients against a background uniformly interval velotrainings are studied there

The main causes in the late postoperative period of postoperative complications in patients undergoing surgery for spleen injury, are the changes of coagulation hemostasis, blood rheology changes and immune sta-tus

Objective: To assess the parameters of vegetative support of adaptation mechanisms in determining the nature of the inflammatory response in infants with septic diseases. The study investigated the flow of the dis-ease in 276 children between the ages of 2 months. up to 1 year, were in the intensive care unit for septic pa-tients. The results state the fact of violation of the regulatory function of the ANS in sepsis with the development of the majority of patients hypersympathicotonic state. Children with CNS disease in the perinatal period has been a significant increase in tension of adaptive mechanisms, is realized primarily by the sympathetic-adrenal structures VNS and manifested hypersympathicotonia they constitute a risk group, under certain conditions they have severe infectious and inflammatory diseases, including sepsis

The article presents the data to determine the level of 25(OH)D in the serum and its impact on preven-tion in 466 children. It is established that during the traditional prevention of rickets, its efficacy remains low, as evidenced by the high incidence of rickets and low 25(OH)D in the blood serum of 86.1% of children. Whereas, when the modified prophylaxis in 90.7% of children the level of 25(OH)D was normalized. Modified
prophylaxis reduces severe rickets; improve psychomotor development of the child in the first year of life.

Data of clinical examination and treatment of 25 reproductive age women with pulmonary tuberculosis are presented in the article. It is shown that in female patients with pulmonary tuberculosis significant part of genitalia diseases belongs to menstrual cycle violations (MCV). The diagnostic value of ultrasonographic ex-amination in determination of menstrual function violations in this contingent of women is established. Efficacy of Tivortin-aspartate administration in multimodal treatment of menstrual cycle violations under tuberculosis is proved

Endometrial hyperplasia (ET) is the most common disease of the mucous membrane of the uterus and is treated as a non-physiological proliferation of endometrial glandular accom panied by restructuring and, to a lesser extent, the stromal tissue components. One of the most common treatments of EHP without atypia is con-ducting hormone replacement therapy. It is known that the use of COCs for 12 months reduces the risk of en-dometrial cancer by 50%. Under the influence of COCs, endometrium undergoes rapid regression in the prolif-erative phase, premature secretory transformation of the glands appears inside it and deciduous transfor-mation is observed in stroma. In order to determine the effectiveness of low-dose COCs in prolonged regime with endometrial hyperplastic processes the based on the gynecological department of the Samarkand Regional General Hospital №1 was conducted comprehensive clinical and laboratory examination of 30 patients with endometrial hyperplasia in premenopausal. Selection criteria investigation - histological verified diagnosis of endometrial hyperplasia without atypia.

This article shows the evaluation of the implementation of the enhanced protocol of medical and peda-gogical observation of children engaged in sports schools of Uzbekistan. The study involved 120 students of youth sports schools of Tashkent aged 11-17 years engaged in athletics, football and ganbdolom. The study results showed that the carrying out of medical and pedagogical observations of enhanced protocols and cor-responding reorganization of the training process and rationalization of loads have led to improved dynamics of their physical development without deviating from the standards of age, physical fitness and reduce the indi-ces of morbidity.