No. 1 (2025) Journal of Multidisciplinary Sciences and Innovations

Cancer remains one of the leading causes of morbidity and mortality worldwide, necessitating the search for effective preventive and therapeutic strategies. Recent research has highlighted the significant role of dietary bioactive compounds in cancer prevention and treatment. Broccoli (Brassica oleracea), a member of the cruciferous vegetable family, has been extensively studied for its potent anticancer properties, primarily attributed to its high content of phytochemicals such as sulforaphane (SFN) and indole-3-carbinol (I3C).

Sulforaphane, an isothiocyanate derived from glucoraphanin, exhibits multiple anticancer mechanisms, including the induction of apoptosis, inhibition of cell proliferation, and modulation of oxidative stress and inflammation. It has also been shown to inhibit histone deacetylase (HDAC) activity, leading to epigenetic regulation of tumor-suppressor genes. Additionally, sulforaphane activates the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, enhancing detoxification and cellular defense mechanisms against oxidative damage [1].

Indole-3-carbinol, a derivative of glucobrassicin, exerts its anticancer effects by modulating estrogen metabolism, reducing pro-inflammatory cytokine production, and interfering with key signaling pathways involved in tumor progression. Upon ingestion, I3C undergoes conversion to 3,3′-diindolylmethane (DIM), which has been found to downregulate NF-κB and COX-2 expression, reducing chronic inflammation associated with cancer progression [2].

The synergistic action of SFN and I3C has been demonstrated in various preclinical studies, showing enhanced inhibition of tumor cell growth and increased apoptosis rates when used in combination. Research suggests that these compounds may be particularly effective in preventing hormone-dependent cancers, such as breast and prostate cancer, while also showing promising results against colorectal, lung, and pancreatic cancers.

Despite their promising therapeutic potential, challenges remain regarding the bioavailability and stability of these compounds, necessitating further research into optimized delivery methods and clinical applications [3]. This review aims to provide a comprehensive analysis of the molecular mechanisms by which sulforaphane and indole-3-carbinol exert their anticancer effects, the findings from experimental and clinical studies, and the future potential of these compounds in cancer prevention and treatment.

Hepatitis B virus (HBV) infection remains a global health burden, affecting approximately 296 million people worldwide and contributing to liver cirrhosis and hepatocellular carcinoma (HCC). Although antiviral medications such as entecavir and tenofovir are effective, they do not eliminate the virus completely and may cause drug resistance and toxicity. This has led to growing interest in natural medicinal remedies for Hepatitis B treatment and liver protection [1].

This review explores the most effective plant-based and natural therapies used in traditional and modern medicine for HBV management, including herbal extracts, flavonoids, polysaccharides, and bioactive compounds [2]. Key mechanisms include antiviral activity, liver regeneration, immune modulation, and hepatoprotection. Scientific studies on natural compounds such as silymarin (milk thistle), curcumin (turmeric), glycyrrhizin (licorice), and Phyllanthus amarus are analyzed, alongside their potential role as complementary therapies in chronic HBV treatment [3].

 In this article, the author tried to clarify the psychological features of feeling the gap in boxers by studying the scientific and theoretical literature of international scientists using a new methodology. The author measures nine types of intermediate distances in boxers (Opponent: moving away, approaching, turning right, turning left, Me: approaching, moving away, turning right, turning left, stepping) international class masters of sports, masters of sports, candidates for master of sports, first, second and conducted research on three hundred boxers with a third sports degree. He tried to clarify the psychological and pedagogical elements of boxers' sense of distance using a device that allows accurate measurement and development of distance. In his experimental studies, he tried to determine the formative years of the boxers' qualifications and their development of the intermediate distance in the fight from an empirical point of view. At the same time, based on the results of his scientific research, he gave suggestions and recommendations to boxers and trainers on how to form an intermediate distance in a short time.

Auctions are a very popular form of trade in many countries today, particularly in Europe, America, China, Japan, and Arab countries. In them, an object is put up for public sale and a kind of competition is organized among buyers to buy this object, and whoever pays the most money wins the sale.

This article mainly discusses the 4 formats that are currently common in the world. (English, Dutch, sealed first price, vickry) auction sales, their positive and negative aspects are covered.

The article presents an evolution and the origins of translation studies, and discusses a range of theories, techniques, and theoretical frameworks that influenced its development. Despite being a relatively new discipline, translation studies have seen significant changes. The need for this profession in the modern, globalized world has brought the early theories of translation under examination because they had to take into account much more than just word equality in order to meet the demands of the complex and dynamic field of translation.

This article examines the artistic interpretation of the image of birds in the work of the modern Karakalpak poet S. Ibragimov and its artistic function in expressing lyrical experience. The poet reflects on the peculiarities of the creation of the image of birds in his work.

Neurocirculatory asthenia (NCA) is a functional disorder affecting adolescents, characterized by autonomic nervous system imbalances, cardiovascular symptoms, and psychological distress, significantly impacting their quality of life. This article examines the regional characteristics of primary and secondary prevention strategies aimed at improving the well-being of adolescents with NCA. The study emphasizes the role of early diagnosis, lifestyle modifications, psychological support, and regional healthcare approaches in managing this condition.

The article presents analyses of the state of the competitive environment in the medical services market of the Republic of Karakalpakstan.

This article discusses the formation of artistic-aesthetic competence of future visual arts teachers and the use of effective technologies in pedagogical conditions.

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This article is dedicated to an in-depth study and analysis of the works of Alexander Fainberg, a renowned Russian poet, translator, and author of numerous poetry collections. As a poet well-versed not only in Russian and European poetry but also in Uzbek poetry, Alexander Fainberg synthesized and reflected these influences in his creative work. He skillfully translated the verses of Navoi’s ghazals, Erkin Vakhidov, Amon Matjon, and many other outstanding Uzbek poets. This article explores how he expressed his love for the Uzbek people through his literary works.

This article talks about clinical linguistics and its role in the study of language disorders, the brain mechanisms of speech activity and those changes in speech processes that occur with local brain lesions.

The competence also develops social skills such as group work, collective discussion and effective exchange of ideas among students. Visual aids play an important role in this process, as they help motivate students, enliven learning activities and clearly express ideas.Visual aids serve as an important methodological tool in the development of communicative competences, and research in this area makes a significant contribution to improving the quality of education.

This article explores national wrestling as a comprehensive activity aimed at preserving, protecting, and advancing the culture and values of one’s nation. It emphasizes the importance of promoting national wrestling among women, particularly in the contemporary world, where women play a vital role as key builders of society. The discussion includes strategies for shaping and developing national wrestling while addressing the opportunities and challenges faced by women in this endeavor.

this article analyzes scientific theoretical literature dedicated to the importance of national values in the educational process in the teaching of psychological sciences. The need to carry out transformational processes in an acceptable and evolutionary way is also expressed in educational work by introducing the most sara aspects of national values into today's educational system.

Alcoholic polyneuropathy (AP) is a neurological disease characterized by impaired functions of multiple peripheral nerves due to the toxic effects of alcohol and its metabolites on nerve fibers and subsequent metabolic disorders in them.

Changes in the activity of hepatic cell (hepatocyte) enzyme systems are at a stage of development or not fully studied. Among the recent findings is the fact that possible qualitative changes in the catalytic activity of enzymes occur when exposed to hepatotropic toxins.

The system of higher education is designed to develop critical thinking, to orient students towards mastering creative ways of solving life problems, self-development and self-education.

There are no clear paths to critical thinking. However, there is a specific set of learning environments that can be used to develop critical thinkers.

This study explores the classification of words into grammatical categories in English and Uzbek, emphasizing the challenges of categorization due to contextual variations. While traditional linguistic approaches divide words into independent and auxiliary parts of speech, modern linguistics continues to debate the number and classification principles. Various scholars, including G. Sweet, B. Ilyish, and E. M. Gordon, have proposed different models based on lexical, morphological, and syntactic features. The analysis highlights the interplay of meaning, form, and function in grammatical classification, demonstrating that words may shift categories depending on context. Comparative studies reveal that both English and Uzbek share grammatical universals while exhibiting unique structural differences. The findings contribute to the ongoing discourse on linguistic categorization and grammatical analysis.

Gangrenous pulpitis is a severe dental condition requiring careful management in pregnant women to ensure maternal and fetal safety. This paper explores diagnostic methods, root canal therapy, conservative treatments, and safe pharmacological interventions. The importance of minimizing stress, using pregnancy-safe medications, and employing alternative techniques such as laser therapy is highlighted. A multidisciplinary approach integrating preventive care and psychological support is essential for optimal outcomes, ensuring effective infection control while safeguarding both maternal and fetal health.

in this article , we will now look at the specifics of organizing inclusive education in primary education, specific benefits or disadvantages , changes in schools and children's training, and again several experiments on organizing inclusive training in a number of our schools in the Republic, you can get acquainted with this information.

 Under laboratory conditions, seed germination and grass strength is much higher. Sowing seeds affect the temperature of water and air. At low temperatures, seeds slowly absorb water, causing the seeds to fall from the cornea and slow down the growth process. The seeds are sown at the beginning of the process, and their wheat flourishes, occasionally sprouting grass. However, sowing seeds early will lead to relatively high yields. This is explained in such a way that every plant that grows from seeds that grows in the early stages is particularly productive, resulting in a volume of space in the field. Sowing grain at night results in poor performance. This is mainly due to adverse weather conditions.

The article describes the main causes of headaches in children and adolescents. It covers the issues of treating headaches in childhood, in particular the importance of non-steroidal anti-inflammatory drugs. The central place in this is occupied by ibuprofen.

This article analyzes the didactic features of such an important process as the acquisition of a communicative style, which plays an important role in the social and spiritual activities of educators. As is known, the communicative style is a system of methods and ways of using professional and social relations based on the correct and effective transmission of information, as well as its analysis, organization and implementation. To facilitate the process of information exchange, increase efficiency and ensure the transfer of knowledge, learning is of paramount importance as a priority task.

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