No. 4 (97) (2017): Problems of biology and medicine

In work studied character of the influence of the cryopreserved nucleated cells of cord blood on the skin
morphology was investigated on the different stages of skin cultivation in vitro and character of the influence stem cells of cord blood on morphofunctinal condition of a derma in conditions of an experimental hypothy-roidism in vivo. The application of cord blood stem cells is perspectives as therapeutic treatment of derma

The combination of rheumatoid arthritis and nonalcoholic steatohepatitis can have adverse prognostic significance for the patients’ quality of life of. Identify relationships between the rheumatoid arthritis course, treatment methods and liver morpho-functional state, skeletal system, lipid metabolism, intensity of lipid perox-idation under a combination of rheumatoid arthritis and nonalcoholic steatohepatitis. All patients were exam-ined with including of morphological study of the liver, skeletal system, blood lipid spectrum, syndrome peroxi-dation and endotoxemia. Correlation interaction between quantitative variables were calculated using the Pearson coefficient. Correlation analysis of the calculation coefficient Spearman's rank correlation was used to assess the relationship between signs

The liver not only absorbs glucose from the blood and deposits it in the form of glycogen, but also syn-thesizes glucose from non-carbohydrate sources of proteins and fats. maintains a constant level of sugar in the blood. Currently, there are more than 150 million people with diabetes mellitus (DM2) in the world, according to WHO. The metabolic disorder in DM2 leads to a disruption in the function of the hepatobiliary system (HBS), whose pathology with DM2 is least studied

Haemophilus influenzae type b is one of the common causes of generalized infection (bacteremia) in
children, half of them developed purulent meningitis, quite often (15-20%), pneumonia, and rarely other focal
lesions. In countries where the vaccination campaign against Hib-infection, there is a decrease in morbidity
and frequency carrier Hib. Vaccination, in these countries, has led to a decrease in carrier frequency in a population of healthy children up to 0.5-1.0%. However, vaccination coverage of infants, vaccine efficacy ACP-Hib, preservation of antibody titer in the infection and their comparison with the reduction of morbidity during the vaccination have not been investigated. Figuring allow them to improve preventive measures in organized and unorganized babies on Hib-infection and to assess their cost-effectiveness. All of the above was the object of study

Anamnestic analysis of the causes of keloid scars in the region showed that the main cause of keloids is a post-acne keloid scars that occur in adulthood

For today an important achievement should be considered the possibility of constant monitoring of the level of drugs in the blood plasma of patients with epilepsy. 156 children with various forms of seizures were examined; in all patients antiepileptic therapy was assessed depending on the EEG and the patient’s age, thereby obtaining control over attacks and correcting the cognitive defect in time

There were 93 girls aged 14-17 years with iron deficiency anemia. Neuropsychological research A number of methods for highlighting essential features, the method of memorizing by AR Lurin, the study of attention on Schulte tables, mental performance according to V. Kogan. All this made it possible to identify violations in 82.8% of girls with iron deficiency anemia

The developed and implemented model of the electronic cabinet of a healthy child made it possible to in-crease the availability and effectiveness of the preventive work of the pediatric service at the regional level

The 27 preterm and 23 full-term newborns with cerebral ischemia was examined. The clinical charac-teristics of the cerebral ischemia depends on the gestational age. The I st degree of the cerebral ischemia caused with neural-reflex excitability syndrome, the IId degree - with hypertensive-hydrocephalic and the IIId degree of the cerebral ischemia - with oppressive syndrome. The convulsive syndrome is equally found at the Ist and IId degrees of the cerebral ischemia

During the period 2010-2015 were observed 42 patients with odontogenic cysts of the jaws. From them, extended defects of the jaws have been observed in 32 patients. For suffusion of osseous cavity with platelets rich plasma of the blood were used to these patients. In the first 12 hours of postoperative period the infiltra-tion margins of the wound were expressed in 2 patients. Elimination of postoperative wealing were observed for 6-7 days. In a month and following periods of observation there wasn’t any complaints by patients, the mu-cous membrane of surgical operation was in pale pink color, without wealing. In the 6th month were observed full restoration of defects in rentgenological checkup. The usage of osteoplastic materials in right way will con-tributes for restoration of large bone defects with organotypical bone formation, corresponding the anatomy of the area, in optimal period, which makes short the period of post operational rehabilitation period of the pa-tients and will contributes early functional exertion of the organs

According to the data collected by us Gilbert's syndrome is combined with functional diseases of a biliar tract, mainly with dyscinesya of a gall bladder. The last researches showed that this hereditary syndrome is risk factor of development of diseases of a gall bladder, including a biliar sladje, cholelithiasis

In the surgical department of the 1-city hospital of Samarkand city clinic for the period 2008-2016, 2563 patients were operated on the CLS, of which 1194 (46.6%) LHE was produced, 347 (13.5%) patients operated from laparotomy access. In the presence of contraindications to LHE, 1022 (39.9%) patients underwent chole-cystectomy from the mini-access. In MLHE lesions of extrahepatic bile ducts were noted in 2 (0.08%) patients. With LCE for the same period, 6 (0.23%) patients had a lesion of extrahepatic bile ducts. Thanks to the im-proved method of cholecystectomy from minilaparotomy access, Zakharov N.I. The number of complications decreased from 2.2% with the standard MLHE by M.I. Prudkov, up to 0,6% in the implementation of MLEFA on an improved method

NUP type B was studied in 80 patients with chronic heart failure in patients with arterial hypertension. Of them, in 32 (40%) patients with arterial hypertension with obvious clinical signs of CHRONIC HEART FAILURE, the number of NUP was higher than the normal values. The remaining 48 patients (60%), which arterial hypertension with CHRONIC HEART FAILURE clinical and instrumental signs of moderate group of 37 patients (77.1%) of blood plasma BNP amount of the normal parameters identified low (less than 200 pg / ml). 11 (22.9%) of the amount of the BNP 220+ 10.1 pg / ml (normal parameters identified above). That is, patients of this group still have the development of CHRONIC HEART FAILURE, despite the fact that patients do not have clinical and instrumental signs

We examined 128 patients with the age from 18 to 35 years. 20 individuals without preexisting lower respiratory tract diseases were chosen for comparison as a seperate group. They were clinically and endoscop-ically dignosed with a foreign body of the respiratory tract and underwent bronchoscopy with bronchoalveolar lavage for bacteriological analysis. 108 patients were diagnosed with recurrent bronchitis (ICD-10 J.40). These patients were further divided into 3 groups. We also performed the additional bacteriologic analysis of feces in order to determine the relationship between changes in the bronchial microbiocenosis under the influ-ence of the antibiotic therapy in comparison with the changes in the intestinal biocenosis. 80% of patients from the group III (no lactobacilli bacteria and bifidobacteria), who received antibiotics, demonstrated chages in bronchial microbiocenosis, which were statistically different (р
0,05) from the parameters of the microbioce-nosis in the group I (control), where antibiotics were administered in 47,5%. In the patients from the group II, where antibiotic therapy was used in 72,2% of patients, either lacto- or bifidobacteria were found. However these changes were not significantly different (p0,06) from the parameters of the group I, which may indicate the incompleteness of negative changes in the bronchial microbiocenosis. Based on the acquired data we found lactobacilli bacteria and bifidobacteria in bronchoalveolar lavage in 100% of examined individuals, who had no prior lower respiratory tract diseases

The paper analyzed the treatment of 18 patients with ruptured-vision of the C2 vertebra. Men -15 (83,3%) women 3(16,7%). Age of patients varied from 18 to 47 years, an average of 31 years. The mechanism of injury was dominated by road traffic accidents -12 (66,6%) of cases, at least - drop – 4 (22.2%), and snor-kelling in shallow water–2 (11.2 %). In the neurological status was dominated by a syndrome of cervicalgia, limitation of motion of the cervical spine, paresis in the limbs. Application of Halo apparatus makes it possible to eliminate the displacement of bone fragments, to restore anatomical relationships in the craniovertebral re-gion with simultaneous fixation of the cervical vertebrae and allows you to start the RAS element the revitaliza-tion and rehabilitation of victims. The installation of the show-on all patients when there is significant bony deformity. If the reduction is achieved by the regression offset, the further treatment is carried out in a Halo machine. Indications for occipitospondilodesis are the inability to eliminate deformation using a Halo-
apparatus and the absence of significant deformation at the level of С2 vertebra

An integral part of the pathogenesis of diabetes mellitus type 2 is the metabolic syndrome, which is also a perspective target for therapeutic correction. The modern direction is the usage of nanotechnology. Using nanoparticles can optimize the effectiveness of therapy, minimize side effects and improve compliance. Based
on the model of the experimental metabolic syndrome induced by the high-fructose diet, the influence of the combined medicinal product on the basis of Goat’s Rue and its liposomal form was studied. The results indicate that the effectiveness of Galevit exceeds the one of the pharmaceutical agent based on Goat’s Rue in the usual form and is not inferior to the reference preparation Arfa Kombi, which is confirmed by a significant reconstruction of the indices. The obtained data provide evidence of the prospects of further pharmacological research of the liposomal form of the new combined drug, Galevit, with subsequent implementation into clinical practice.

Experimental investigate of upgrade methods of suture of large intestine anastomosis is carried out. Ex-perimental investigate was fulfilled on the 28 mongrels. Application of improved methods of suture of large intestine anastomosis has improved results of treatment acute obstruction of sigmoid colon

The experiment model of polytrauma of animals 3, 6, 24-month old was conducted according to the method of A.A. Hudyma. The research was conducted after 1, 3, 24 hours and for 14 days after modulation of polytrauma. The activity of processes of lipid peroxidation was judged by the content of TBK-active products. Activity of superoxide dismutase, catalase and the content of ceruloplasmin was determined by biochemical methods. Statistic processing of material was carried out by parametric methods. The analysis of the relation-ship between the two features in the presence of a normal distribution was estimated by the results of the corre-lation analysis by Pearson. We have established the relationship between lipid peroxidation and AOS in three-month young rats in the early stages after the polytraumatic modeling. At 1, 3 and 24 hours after the polytrau-matic modeling, lipid peroxidation indexes increased and enzymes of AOS were activated. In late terms after the modeling of polytrauma (14 days) in animals of 3 months old AOS protection was absent by the established
direct strong correlation between the activity of SOD of the liver and blood CP (r= 0,73, р0,05). In 6 and 24-month old rats, after 1, 3, and 24 hours after polytraumaticsmodeling, there were found inverse statistically significant correlation connections between MDA level and AOS indicators. In the late stages of the modeling of polytrauma of animals of 6 and 24 months old there was a depletion of enzymatic link of AOS on the back-ground of high content of MDA. The increase of intensification of lipid peroxidation processes leads to a de-crease in the adaptation resources of AOS in animals of different age groups with polytrauma and vice versa, increase in exhaustion of the AOS potential leads to activation of lipid peroxidation which induces peroxidation
processes in polytrauma. It predicts the progressing of misbalance in antioxidant system in injured animals in
different terms of polytrauma.

When prescribing NSAIDs and antiplatelet agents, the doctor must constantly weigh the risk and benefit of treatment. It should be remembered that any NSAIDs, ASA, clopidogrel and other antiplatelet agents in-crease the risk of erosive and ulcerative gastrointestinal lesions, as well as the likelihood of ulcerative bleeding and perforations

Relevance. In recent decades, in many countries of the world, there has been a trend towards an increase in the number of patients with chronic diffuse liver diseases (CDLD), especially among people of young working age. CDPD is characterized by a severe course, poor prognosis, and is one of the main causes of disability in patients in developed countries [1,2]. According to WHO, cirrhosis of the liver (LC) ranks eighth among the causes of death. Therefore, the study of the features of epidemiology, clinic, diagnosis, treatment of these diseases is one of the urgent problems of modern hepatology.

Laboratory diagnostic methods are of particular importance in scientific research and medical practice in conducting comparative diagnostics and facilitating the diagnosis.
At the same time, the most convenient and widely used method is the study of biological fluids, in particular, the composition, functional state of various organs and systems, hormonal changes, integration of anabolism and catabolism norms. However, modern analytical methods do not provide integration of data evaluation in biological fluids, since they determine only the quantitative composition without analyzing the interdependence of the quality of individual metabolites through large amounts of substances in biological fluids.

The term "colostomy" currently refers to an artificial anus, surgically imposed on one of the sections of the colon for permanent or temporary removal of feces from the distal intestine. The term is used to distinguish an artificial anus formed for therapeutic purposes from a colonic fistula resulting from a disease (appendicular or other peritonitis, intussusception, etc.) or colon injury. In recent years, the number of diseases of the large intestine, requiring the imposition of an unnatural anus, not only did not decrease, but also increased by 2-8% according to different authors [1,5,16].

In every family, the birth of a child is a happy event, especially for the mother herself. However, the birth of a premature baby changes completely or partially the emotional state of both parents and others. At the birth of a premature baby, with the corresponding consequences, any woman experiences anxiety, worries about the health of her child. Very often, such mothers develop depression [4].

The idea that there is some kind of relationship between the various signs of living beings originated in ancient times (Hippocrates 460-377 BC). However, the first major generalization in this area belongs to J. Kovier, who in 1806 first proposed the term "correlation", and in 1815 put forward two principles - coordination and correlation.

In patients with rheumatic diseases, complications in the gastrointestinal tract are more common than in the general population - in 10-40% of patients treated with high (anti-inflammatory) doses of NSAIDs and having appropriate factors risk. At the same time, severe complications can develop in 25% of cases: peptic ulcers, bleeding, intestinal inflammation [1-4]. The extremely widespread use of NSAIDs, including low-dose aspirin (for the prevention of thrombotic complications), especially in elderly and senile people, who have a particularly high risk of gastrointestinal complications, necessitates the development of methods for the prevention and treatment of NSAIDs. - gastropathy.

The problem of interaction between man and his environment is especially acute in regions with a dry hot climate, which include Uzbekistan. Solar radiation is
the totality of solar matter and energy entering the Earth. Energy propagates in the form of electromagnetic waves at a speed of 300 thousand kilometers per second, passes through the atmosphere and reaches the Earth in 8 minutes. earthly the surface is under the influence of both direct and scattered by the earth's atmosphere, the sun's rays. It is the scattering of blue-blue rays in the atmosphere that explains the blueness of the sky on a clear day. Yellow-orange color The finite disk is due to the fact that the waves corresponding to it pass almost without dispersion. The electromagnetic spectrum of solar radiation consists of infrared (50%), visible (41%) and ultraviolet (9%) parts. Because they quanta have different energies, they have a variety of effects on a person. The hygienic significance of solar radiation is also extremely high. Its regulation is carried out in accordance with SNiP, which for solar radiation are compiled taking into account light
climatic features of various geographical zones and are taken into account in the design and construction of various facilities

In Uzbekistan, including in the Samarkand region, in accordance with the Decree of the First President of the Republic dated November 10, 1998 No. 2107 "On the State Healthcare Reform Program", the Republican Center for Emergency Medical Care, its regional departments, as well as emergency medical care, have been established and there are ambulance and air ambulance services, including ambulance teams. Comprehensive measures are being taken to equip emergency medical facilities with high-tech medical equipment and specialized vehicles.

The work assesses behavioral disorders in children with different tics. 181 children from 7 to 12 years old were examined. The most frequent hyperkinesias were blinking and lifting of the eyebrows, neurotic-like tics were 54.7%, in children, headache was diagnosed in 8.5%, stammering was 23.2%, in 48% signs of atten-tion deficit hyperactivity disorder, especially with Tourette's syndrome. The level of anxiety was greater in children with transient tics.

Scrotal skin tumors are found quite often and easily diagnosed, that can not be said for tumors of the scrotum tissues themselves. Lipoma - benign tumor that develops from adipose tissue. Intrascrotal primary li-pomas, originating from fat cells of the subcutaneous tissues of the scrotal walls themselves, are very rare and vary in size. In this article, we describe the clinical case of a patient with intrascrotal lipoma

Under observation were 49 men with benign prostatic hyperplasia who underwent treatment with an α 1 -
adrenoblocker-tamsulosin. The analysis of the results of the evaluation of the quality of life index in groups of patients with prostatic hyperplasia who received tamsulosin medication demonstrated a significant decrease
(improvement) in the mean value of the quality of life index in the treatment of patients. In most patients, the
severity of adverse reactions with tamsulosin was insignificant and did not interfere with the daily activity of
the patient

Data of retrospective analysis of 190 histories of patients with a burned howling disease given. Patients were diveded into 4 groups, depending on the severity of the burn disease. And during the shock period blood pressure slightly increased in the erectile phase and decreased in the torpid. And prognostically unfavorable cases already in the carly periods revealed persistent hypotension. Pain in the heart tachycardia, hyponetsion were noted in patients with moderate severity of the burn disease. With a mild degree of disease moderate tachycardia was observed and a sligh increase in maximum blood pressuare was observed. In patients with burns of I-II degree occupying less than 10 % of the surfaces of the body, the burn disease did not clinically appear

The modern development of methods of ultrasonic diagnostics assumes survey of all surface trunk venous
course, an assessment of different options of a structure of veins, their valvate device throughout and allows to
reveal local damage of veins directly. Conclusions. At the isolated varicosity classical and low-invasive meth-
ods of treatment are used, each of which has the advantages and shortcomings. The basic principles of a sav-
ings flebektomiya consist in use of tactics and methods of treatment which allow to keep BPV trunk for the shunting operations in cardiovascular surgery. The isolated varicosity is followed by local defeat of superficial venous system. In the concept of savings surgery treatment doesn't demand performance of a flebektomiya of trunks of BPV or MPV. For the safennykh and the perforantnykh of inflows method of the choice is vysoko-tochny crossing of a varicose vein in the mouth with the subsequent sklerozirovaniye or surgical removal

Increasing training loads and the intensity of competitive activities require athletes to tremendous strain of physical and moral strength. One of the most important components of ensuring a high level of functional status of athletes of children and adolescents is a balanced adequate nutrition

The article retrospectively analyzed the incidence of kidney cancer in the Samarkand region in the peri-od from 2006 to 2017, and the status of diagnostics and treatment. In the structure of cancer pathology in Sa-markand region kidney cancer constitutes 2.7% and takes 12th place. We may observe increase in the inci-dence of kidney cancer over the last 7 years up to 1.8 times and a low detection of process in early stages. This study is based on the diagnostics and treatment results of 415 patients with kidney cancer. Diagnostic status until 2015 in the area did not meet the requirements of the standard. Over the past 3 years in connection with the introduction of the technique needle biopsy, percutaneous nephrostomy and appearance of ability to apply MSCT, dramatically increased the efficiency of diagnosis, and that influenced the treatment results. Radical nephrectomy performed 162 (39,0%) patients, palliative 63 (15,2%) patients. Chemo - and immunotherapy 53 (12,8%), immunotherapy 62 (14.9 %) and more modern targeted therapy 12 (2,9%) patients, 58 (14,0%) pa-tients underwent symptomatic therapy and in 5 (1,2 %) patients treatment was not conducted

The purpose of this study was to evaluate the associative relationships of biochemical indices of the in-flammatory process with the virus C genotypes in patients with chronic hepatitis in representatives of the Uzbek population. The subject of the study were patients with HCV-infection and cirrhosis of the liver, as well as healthy donors, in which DNA samples were obtained. Specific features of the clinical course and association of the genotype of virus C with biochemical indices for different severity of the course of CVHC were deter-mined

The study included 177 patients aged 14 to 65 years who entered the state of burn shock of varying de-grees. The frequency of the development of digestive and absorption disorders depends on the severity of the thermal injury. Treatment of patients with the syndrome of intestinal insufficiency helps to reduce complica-tions and mortality in patients with heavy burns

Indicators of questioning and organoleptic method of inspection on existence of an unpleasant smell in an oral cavity varied and differed from each other. In our researches organoleptic indicators made 86,6%, we connected a difference between these indicators use by patients various deodorizing means for an oral cavity

The results of the study of combined antihypertensive therapy with drugs of valsartan and moxonidine on hemodynamic parameters, lipid and glycemic blood profiles in patients with metabolic syndrome and arterial hypertension are presented. A rational combination of antihypertensive drugs allowed achieving the target lev-el of blood pressure, normalizing the circadian rhythm of blood pressure, metabolic processes, in particular lipid and carbohydrate metabolism

The High percent of the complications survival and low sick dictate need of the improvement medical tacticians at bleedings from varicose extended vein gullets. At present for stop and preventive maintenances of the bleedings from varicose extended вен gullets (VRVP) use the facility an endockopic, medikamentoz, and surgical gemostaz. Our purpose to introduce in practical person endockopic scleroterapy and alloying at bleedings under varicose extended вен gullets. In consequence of which will is reached reduction of the re-lapse of the repeated bleeding and complications, miniinvaziveness method and mortality

This article explores the observation of the clinical results of the 54 patients treated with thoraco-
abdominal surgery and urology departments on the basis of the Samarkand city medical Association in 2011-2016. Of these, 46 patients produced lumbotomies, 2 myofascial and 6 patients in laparoscopic operations. All patients were divided into two groups. The main group of patients with hernioplasty and tummy tuck, patients in the control group produced hernia repair with local tissues. And the group's attention to the comparison of the results of operations for the following parameters: various postoperative complications are rare, the reduction of recurrence in patients with postoperative rehabilitation

The aim of the study was a comparative analysis of the genotypic variants of the TNF-α and CTLA-4 genes in patients with chronic hepatitis C and liver cirrhosis and their effect on the course of the disease. The analysis of the influence of the genotypes of the TNF-α gene on the course of the disease indicates an increased risk of CVD with both moderate and highly active course of the disease in carriers of the combination of geno-types G / A + A / A. The obtained data allow us to conclude that the carriage of the allele "G" and the combina-tion of the A / G + G / G genotypes of the -49GG polymorph of the CTLA-4 gene are associated not only with a decrease in the risk of development of HCVF, but also with a lower intensity of inflammation and fibrosis in the liver and a high probability favorable course of the disease.

EEG analysis was performed in norm and with epilepsy in different age groups. As a results of the ob-servation of 168 patients with epilepsy, a prounced immaturity of the broun is determined in the group of chil-dren, which gives the risk of high epileptic activity. Epilepsy in the older age group should be considered as “invasive”, if there is an attack on the EEG, there is no change.

EEG analysis was performed in norm and with epilepsy in different age groups. As a results of the ob-servation of 168 patients with epilepsy, a prounced immaturity of the broun is determined in the group of chil-dren, which gives the risk of high epileptic activity. Epilepsy in the older age group should be considered as “invasive”, if there is an attack on the EEG, there is no change

The studies were conducted in 102 hospitalized patients from 2009 to 2014 in the offices of multiple trauma, neurosurgery, and neyroreanimations Andijan branch of the Republican scientific center for emergen-cy medical assistance with a preliminary diagnosis of "brain injury". The aim of this study is a clinical study and development of algorithms for treatment of patients with concomitant traumatic brain injury to regional hospitals.

In the article is illustrated results of the survey 51 children (64 ears) aged 1 to 15 years with acute puru-lent middle otitis. Detected etiologic spectrum of causative agent of acute middle otitis. Among etiological de-crypted acute purulent middle otitis, 24% are caused by streptococcus pneumonia. When determining the sensi-tivity of the causative agent of acute otitis media to antibiotics revealed that S. pneimoniae retains high sensi-tivity to amoxicillin, pefloxacin, cefazolin, cefuroxime and ciprofloxacin. Slightly reduced sensitivity to azithromycin

With the purpose of studying the state of trace elements, a study was conducted in 50 patients with he-mophilia associated with hematomesenchymal dysplasia which there cured in the hemophilia center. It was established that in patients with hematomesenchymal dysplasia, there was an imbalance in the microelement status, which was characterized by reliable Mg² + deficiency - 1.6 times, Ca 2+ - 2.1 times, iron 1.2 times com-pared to the control group. The pronounced deficiency of magnesium and calcium can be explained not only by the low consumption of microelements with food products, but also by their dependence on the level of iron and potassium in the human body.

A crystallographic study of tear fluid was performed in 20 healthy and 24 patients with age-related cata-ract. Crystallization of the tear fluid of patients with age-related cataract occurs in the same way as in healthy individuals, and is characterized by the formation of continuous figures in the form of snowflakes, daisies or fern branches

In 72 patients with metabolic syndrome, an enzyme immunoassay was performed to determine the BNP. Of these, 37 (51.4%) patients who had chronic heart failure on the background of metabolic syndrome had a higher BNP of plasma. And in 35 (48.6%) who did not have clinical and instrumental signs of chronic heart failure on the background of metabolic syndrome, 23 of them had a lower BNP. In the remaining 12 (34.3%) patients, the number of BNP was 220 + 10.5 pg / ml. This means that in this group of patients against the back-ground of MS, there is still development of chronic heart failure. To mean a determination in the blood plasma of the BNP makes it possible to diagnose chronic heart failure in the early stages

The steadily growing prevalence in a combination to high frequency and weight of complications sugar diabetis and that for treatment and prevention of complications is required many efforts has resulted in development of this disease from biological in social. Till a stage there are a lot of factors the management sugar diabetis 2 such as under the standards provides ideal indemnification glycaemia and reduces the charges by treatment.

The data of the clinical course of gingivitis in pregnant women are presented. The algorithm of the com-plex of measures for the prevention of periodontal diseases at the level of a dentist in women at different peri-ods of gestation and in the postpartum period has been developed.

The article presents the results of treatment of patients received targeted therapy with Sunitinib on me-tastasis of renal cancer to the lymph nodes. The total number of patients was 38. Male 21 (55.2%), female 17 (44.7%), ratio 1.2: 1. The average age is 50 ± 2.4 years. The complications associated with the use of angiogenesis blockers and tyrosine kinase inhibitors have been analyzed. The main undesirable side effects against the background of Sunitinib therapy, from the side of the blood indices: neutropenia, hypophosphatemia, lymphopenia, anemia, thrombocytopenia, increasing of the serum creatinine and total cholesterol. The results of treatment allow us to recommend the use of sunitinib for the treatment of patients with me-tastases in the lymph nodes of renal cancer, emphasizing the need for timely prevention of complications of this treatment

In this study, in neurosurgical and neurological departments, clinical and neurological features of ischemic stroke in children were studied. 50 children underwent a neurologic examination, an MRI scan and a pediatric PSOM stroke scale. Along with focal symptoms (hemiparesis), general cerebral symptoms were noted, in 23.4% convulsive syndrome. The depth of paresis was higher in school-age children, the dynamics of recovery was slow

Plasmapheresis sessions were performed among 45 patients in JSC “RSCS named after academician V. Vakhidov”. The results revealed that the positive reaction of the pathological process was observed in all pa-tients, regardless of the used method. However, different session number was required to achieve a significant reduction or normalization of the investigated parameters. The session number of standard method ranged from 4 to 5, the same results were observed after 2-3 sessions of modified method. The conducting of plasma-pheresis according to developed method revealed the prominent advantage over the standard method. In all cases, regardless of the reasons for detoxification procedures, we managed to reduce the number of sessions, i.e. to improve the detoxification quality. Thus, developed plasmapheresis method combines detoxification mechanisms of efferent therapy (plasmapheresis) and and indirect electrochemical oxidation of blood (electro-activated solution exposure, i.e. neutral anolyte) which made it possible to increase the effectiveness of the per-formed treatment.