No. 4 (104) (2018): Problems of biology and medicine

Material was the liver of mature rabbits (n=36),that , after common morphological treatment was ana-lyzed under light N 4800 M(x100immersion )and electron microscope JEM-100S. Results: the conducted stud-ies indicate the existense of the porto-venous gradient, in the periportal part, the differentiated cells undergo division as the cells move towards the central vein, their differentiation. Summary: in the liver there is a por-tovenous gradient, in its periportal part it multiplies by mitosis, and in the intermediate and perivenous are as it under goes apoptic death or extrusion

VSU "RPMZ named Akad. V. Vakhidov street" together with NYSAFP Academy of Sciences of Uzbeki-stan developed a new aerial and hemostatic implant "Gabriel" which has passed preclinical testing. The article presents the results of clinical studies of the developed implant. Studies have shown that the use of a biological implant "Geprotsel" has reduced the need for additional single stitching lung tissue to ensure adequate Aero-and hemostasis from 38.2% to 11.4% and multiple strengthening seams from 29.4% to 5.7% (χ2=7,706; Df=2; P=0.021). The introduction of the domestic biological implant into lung surgery allowed to reduce the period to achieve Aero-and hemostasis from 32.8±2.5 to 12.5±1.2 minutes (P<0.001), the total duration of the operation from 135.6±6.1 to 107.2±4.7 minutes (P<0.001), as well as to reduce the duration of pleural drainage from 3.38±0.31 to 2.09±0.06 (P<0.001) and the entire period of hospitalization from 12.1±0.4 to 10.7±0.2 days (P<0.01)

A case of successful myomectomy large intramuscular ischemia myoma over, was node in fist pregnant women in the period of 9 weeks. For decreasing the stage of blood losing before enucleating of myoma staging was using homelier bandaging uterine vessels on the side of tumor localization. A complication isn’t present now, pregnant is progressing and now the term of pregnant period going good of 14 weeks.

The descriptive-evaluative method of epidemiological research was used in the course of the research, a retrospective analysis of 12869 case histories of children, who were hospitalized in the period from 2015 to 2017 years due to recurrence of obstructive bronchitis was carried out. We obtained data on the frequency of occurrence of children with recurrent obstructive bronchitis. By periods of the year, the incidence of recur-rence of the disease in children is in the form of a “wave-like” curve, the severity of which largely depends on climatic conditions. Recurrence of obstructive bronchitis is more common in children at the aged 6 months to 2 years, and the peak rise in incidence occurs between the 2nd and 8th month of life. Basically 1 episode of bron-chial obstruction was observed.

The analysis of the results of surgical correction of anisometropia in 8 patients with strabismus. 4 pa-tients had myopia and hyperopia in 4 patients in the squinting eye. All patients were performed surgery to re-move the lens and IOL installation. The refraction after surgery was from emmetropii to myopia in 1 diopter. Strabismus disappeared in 6 patients. Visual acuity in the operated eye improved in all patients

According to world statistics in recent years, it has been noticed a tendency to increase quantily of pa-tients who need surgical treatment in which difficulties appear because of occurrence of clinically apparent accompanying extragenital diseases, which cause a high risk on anesthesia and occurrence of severe postoper-ative complications. The study was conducted in 108 women with concomitant diseases with suspected intrau-terine pathology aged 53 to 71 years. The study assessed the features of clinical manifestations of gynecologi-cal diseases in the elderly and senile age, and the optimal tactics for managing patients with this type of pa-thology was developed.

The article presents a case of surgical treatment of the consequences of damage of the axillary artery on the left arm of a 3 year old child 2 months after the wound of the left axillary region. The patient, after a comprehensive examination, without technical difficulties, was performed subclavian - brachial autovenous shunting, neurolysis of the brachial plexus and median nerve of the left upper limb. In the early postoperative period, the pulsation on the left forearm arteries is clear. On the control ultrasound dopplerography of the vessels of the left upper extremity, the main anti-hail flow was noted

The effect of LED (blue and infrared spectra) exposure on the sternal wounds has been studied using touch smears for determining the ratio of normal and pathological forms of erythrocytes at the edges of wound and Laser Doppler Flowmetry. It has been established that LED reduces the inflammatory response, normaliz-es the shape of red blood cells and improves skin microcirculation in the wound, and all of these factors con-tribute to accelerated process of healing of injury

According to the CT scan, the victims with CCI can reliably detect the localization and location of foci of brain contusions, intracranial hemorrhages, depressed fractures of the skull bones, as well as linear fractures with sufficient divergence of their edges, and bruising, combined with massive hemorrhages in the soft tissues of the head. The data obtained are confirmed by the results of the section in patients with fatal CCI

We researched the influence of the “Cavergal” on the functional activity of neutrophils during neutro-penia caused by acute blood loss. A positive and protective effect of a “cavergal” on surface receptors (CD16, CD45, CD95) and phagocytic activity of neutrophils was found.

The article gives an example from practice with the analysis of materials of commission forensic medical examination. It was revealed that the main pathology was not recognized, and the treatment, which was due to subjective reasons, was appropriately treated incorrectly

Despite the achievement of modern surgery in nowadays, there is no special delivery device for laparo-scopic surgery in the minimally invasive surgery. This kind of device must meet the following characteristics: the ability to dispense a certain amount of powder in the target zone, safety and efficiency at the high pressure in the abdominal cavity. A new delivery device for the use of hemostatic powder Heprocel in minimally invasive surgery was developed by the developers of SI “RSSPMCS named after acad. V.Vakhidov”. The effectiveness of the delivery device was evaluated experimentally on 8 mongrel dogs weighing up to 7.5 kg. The developed de-livery device ensures an uniform distribution of the hemostatic implant Heprocel over the wound surface of the liver. The proposed device is an effective delivery system capable of transport a dosed amount of hemostatic powder to the target bleeding area during manipulations in laparoscopic surgery

The 96 male rats were randomly divided into two groups. The standard nutrition and drinking water with 0.75% EG as an inducer of stone formation were free for all rats. The first group received an extract from DG; the second group (control) received a placebo. The strong diuretic effect of the extract was found - by 69.1%. A significant change in inhibitors and promoters of urolithiasis was observed: an increase in urine pH and citrate excretion, a decrease in calciuria and oxaluria. The decrease in the activity of lithogenesis was confirmed by a decrease in the AP [CaOx] index by 70.86% from the baseline. The results confirm that diuretic plant has demonstrated the ability of herbal preparations, in addition to the diuretic effect, to influence on factors of uri-nary lithogenesis. The high diuretic effect in combination with ability of DG to normalise the balance of pro-moters and inhibitors, allows us to offer it for the management of patients with urolithiasis

Experiments were performed under the conditions of a subacute experiment on 28 white male rats weigh-ing 160-180 g, divided into 4 groups. The first group was the control. The following three doses were adminis-tered to the animals of the three following animals daily for 30 days: the 2nd group - 1/50 of LD 50 (200.0 mg / kg), the 3rd - 1/250 of LD 50 (40.0 mg / kg), the 4th, 1/2500 of LD 50 (4.0 mg / kg). The content of trace elements was determined on an atomic adsorption spectrophotometer using standard techniques. As a result of the ex-periment, it was found that the dynamics of changes in the concentration of potassium, sodium and calcium ions in the tissues of experimental animals was multidirectional and depended on the amount of sodium stea-rate in the body of animals. The substance in a dose of 1/50 from LD 50 (200.0 mg / kg) adversely affected the mineral metabolism in the body of experimental rats, as evidenced by a significant increase in calcium against the background of decreasing the amount of potassium and sodium in the kidney and brain tissue, as well as a decrease in calcium and growth of potassium and sodium in the liver tissue. These changes develop as a result of the influence of surfactants and are one of the causes and reflection of dismetabolic phenomena characteris-tic of the cells of the body under the toxic effects of xenobiotics.

Thermal burn is a severe form of injury, causing structural and functional disorders in numerous body systems. Because of the complexity of the process and the involvement of several body systems, it is impossible
to analyze this state by in vitro experiments. Over the past two decades, a number of experimental burn models
have been developed. The review examines the healing of wounds in animals with burn injury, the advantages
and disadvantages of these models for rational use. The paper considers three main types of animals used for
modeling burn wounds.

The aim of the study was to evaluate the results of polysomnography in patients with diseases of the up-per respiratory tract on the background of ronchopathy. We studied 50 patients with ENT diseases who were in
the ENT department of the 3rd clinic of the Tashkent Medical Academy in 2015-2017. These patients were di-vided into 2 groups. The first group consisted of 30 patients who had a mild degree of ronchopathy. The second group consisted of 20 patients with a moderately severe degree of ronchopathy. All patients underwent a com-prehensive examination, including polysomnography. The study showed that polysomnography is an effective diagnostic method that allows the distribution of bolt levels by degrees of ronchopathy, snoring intensity, ef-fects on other organs, is also an indication for timely treatment of diseases of the upper respiratory tract for the prevention of obstructive sleep apnea.

The macroscopic structure of the lymphoid structures of the small intestine of rats of 8 months of age was studied in the norm. It is established that the number of GLN, the number of nodules in them, the size of GLN increases from the initial section of the small intestine to the terminal one. The shape of the GLN to move from the initial part to the end part of the small intestine changes from rounded to oval. On average, 2.8% of the small intestine is covered with GLN

According to the conducted studies in children, clinical symptoms were characterized by increased reac-tivity of the organism to trauma, generalization of the processes of excitation and inhibition, violent vegetative reactions, inclinations to hyperergic reactions. When performing a forensic medical examination, comparing the timing of a health disorder with the severity of damage in children, the duration of treatment is used as one of the criteria for the qualification of injuries

According to WHO, the birth rate of children with congenital cleft palate in the world averages 0.5-1.5 per 1000 newborns. Despite the mandatory set of measures taken at an early age, adult patients with congenital cleft palate have severe morphological and functional disorders that grossly impair aesthetics, phonetics, chewing and swallowing functions [8]. Congenital cleft palate is a common multifactorial malformation and occupies a leading place among all congenital malformations of a person. According to experts, congenital pathology of the maxillofacial region ranks 3rd-5th among all congenital malformations in humans and, on average, one child is born with a cleft palate for 600-1000 newborns [5].

As is known, the main long-term complications in patients with liver cirrhosis (LC) after portosystemic shunting (PSS) are gastrointestinal bleeding (GI) and acute liver failure (ARF) [2, 3, 8]. The development of these complications
the late postoperative period and their severity largely depend on the activity of the patient's adaptogenesis systems to the effects of various endogenous and exogenous factors, as well as the biological responses of the body. However, in a number of cases, these relationships are considered outside of their etio-pathogenetic connection and interdependence, which often predetermines unsatisfactory results you in this group of patients [4, 11]. The increase in the number of different options for surgical intervention in liver diseases, the expansion of indications for organ transplantation, has significantly affected the survival of patients and opens up new opportunities for radical treatment. On the other hand, fundamentally new approaches to rehabilitation programs are required grams, which should be aimed not only at increasing survival, but also at improving the quality of life of patients with diffuse liver diseases [1, 5, 6, 13]. The article presents the main directions and standards of real
of patients with liver cirrhosis after PSSh on the basis of already recognized standards of treatment tactics, the experience of the leading hepatological schools of the world and the own material of the State Institution “RSSPMTSH named after A.I. acad. V. Vakhidov.

Teething is a physiological step-by-step process characterized by the appearance of milk teeth, then permanent teeth in children. Tooth eruption is its axial movement from a non-functional position in the jaw bone tissue to functional occlusion. The dynamics of this process depends on the degree of formation of the root, periodontium and is closely related to the development and growth of the craniofacial complex [1, 20].

Damage to the knee joint is a serious problem in clinical medicine, as it is a fairly common cause of disability and disability [4, 8, 21]. The knee joint is involved in the pathological process in a variety of diseases - deforming osteoarthritis, rheumatoid arthritis, seronegative spondyloarthritis, microcrystalline arthropathies, chondromatosis, injuries. Injuries of the knee joint occupy one of the first places among all cases of pathology of the musculoskeletal system, and from 43% to 80% of cases are injuries of its ligamentous apparatus [4, 5, 8]. Due to the peculiarities of the anatomical structure of the knee joint, its soft tissue structures are damaged more often than the bone components. Ligamentous apparatus injuries occupy the first place and account for up to 50% of injuries of the knee joint, up to 24% of injuries of the lower limb. Chronic injuries of cartilage, menisci, and cruciate ligaments, which are recorded with a frequency of up to 79%, are the cause of the development of degenerative-dystrophic changes in the knee joint [2]. Degenerative-inflammatory diseases of the joints are a common cause of persistent disability in the population of various age groups. Osteoarthritis is the most common joint disease, occurring in 10-20% of the adult population.

Premature rupture of membranes (PROM) is one of the most important problems in obstetric practice. According to some authors, childbirth complicated by PROM during full-term pregnancy is ut from 8.2% to 19.6%, and in case of premature birth (up to 37 weeks of gestation) - from 5 to 35%. Also, different authors note that up to 20-32% of PPROM tends to re-develop in subsequent births [1, 8, 21, 27]. According to the American College of Obstetricians and Gynecologists, rupture of membranes during pregnancy up to 37 weeks complicates 2-4% of pregnancies with one fetus and 7-20% with multiple pregnancies [17, 23]. Misdiagnosis of preterm rupture of the membranes of pregnant women can lead to unreasonable actions (for example, hospitalization or early delivery), and late diagnosis entails a slow reaction of obstetricians and an increase in infectious and inflammatory complications. We must not forget that the management of pregnancies complicated by PROM is very expensive [10].

Cirrhosis of the liver (LC), according to the definition of the World Health Organization (WHO), is a diffuse process characterized by fibrosis and transformation of the normal structure of the liver with the formation of nodes. As a pathological process, cirrhosis is the final stage of a number of chronic liver diseases and today is one of the most difficult social and medical problems, which, unfortunately, in most countries is represented only by conservative therapy or palliative surgery. interventions [1,2,3]. Representing the final histological variant of the transformation of the hepatic parenchyma, a different spectrum of liver diseases can progress to the development of cirrhosis from several weeks to several decades. Often, its first clinical manifestations may appear only when 80-90% of the liver parenchyma is damaged and killed [4]. Disappointing statistics are provided by WHO, according to which 10% of the world's population has chronic liver disease, which is more than 500 million people, with more than 20 million people worldwide suffering from cirrhosis and/or liver cancer. Every year more than two million people die from liver failure [5]. According to WHO forecasts, in the coming decades, the number of patients suffering from cirrhosis will increase more and more by more than 60%, which is due to the wide spread of hepatotropic intoxications and viral lesions of the organ.

The presence in 30-40% [1,5,9,12,35,37,42] of patients of combined surgical and gynecological diseases puts before surgeons and gynecologists a solution to the problem of simultaneous correction of such a pathology, i.e. conducting simultaneous operations [6,7,11,21,25,29,36, 38, 40]. The production of minimally invasive and simultaneous operations emphasizes their undoubted advantages over several consecutive surgical interventions, both in therapeutic and economic aspects, both for the state and for patients in general. [2, 6,8,10,13,14,16,18,19,20,22,23]

The digestive system occupies an important place in the relationship of the organism with the external environment. The mucous membrane of the digestive organs is affected by a wide variety of substances that make up food, and it becomes clear that it is not by chance that the mucous membrane and submucosa have their own lymphoid formations, which are organs of immunogenesis [19,20] .

Breast cancer (BC) is a frequently diagnosed oncological disease, which accounts for 23% of all initially detected cancer cases [19]. Hereditary forms of breast cancer are often associated with a high risk of developing primary multiplicity.
malignant tumors. These neoplasms are characterized by an aggressive course, difficulty in predicting the outcome of the disease, and high mortality.

Over the past decades, scientists around the world have done a lot of work to study the etiopathogenesis, prevalence, intensity of the course of chronic recurrent aphthous stomatitis (CRAS), and various methods of treating this disease have been proposed [12, 17].

Introduction. According to various authors, the frequency of detection of uterine fibroids among the modern female population ranges from 20 to 77% [5, 6, 8]. At the same time, there is a noticeable increase in the incidence among women of reproductive age [1, 2, 8]. Considering that in modern conditions women often realize their reproductive function after 30 years, the issues of management of uterine fibroids in patients of reproductive age have grown into an independent topical problem. Fragmentation of works, contradictions, lack of protocol schemes for treatment and rehabilitation, creates a lot of questions about the management of this category of women. A number of researchers see a solution to this problem in the introduction of clinical protocols, which should become the basis for the formation of the medical State Standard [8].

Burn shock is the first stage of burn disease and develops when the surface of the body is affected by an area of 10-15% with superficial and 5-10% with deep burns [6,11,14].

Early fetal echocardiography, performed between 12 and 16 weeks of gestational age, is technically pos-sible using the heart ultrasound protocol and can identify a wide range of significant heart abnormalities. In addition, it allows to evaluate the progression of the disease and, given the beginning of the widespread use of intrauterine interventions, can provide an earlier and effective fetoscopy

As a result of a study of 129 patients with epilepsy, a high frequency (73.6%) of associated psychopatho-logical disorders of anxiety and depressive nature was detected, with their prevalence in women (66.1%). Dis-tinctive clinical features of epilepsy associated with anxiety and depressive disorders are pharmacoresistance, the prevalence of simple partial ideatorial and emotional-affective seizures and the presence of affective disor-ders of the anxiety-depressive circle in history before the onset of the disease (79.8%)

Were studied the state of the initial autonomic tone in children perennial allergic rhinitis. Among 42 patients (68,9 per cent) were persistent, and 19 (31,1 per cent) – intermittent form CT. According to the analysis of clinical signs IWT in 28 (54.9 per cent) of children identified CT status, the prevalence of parasympathicotonia (vagotonia), 28(54,9per cent) - eatonii (balanced state of the ANS alone) – 9 (17,6%) of sympathicotonia. In General, CT is not dependent on clinical course, characterized by increased tension of the parasympathetic mechanisms of the ANS. the results indicate about the relationship between IWT and clinical course CT. You can assume the existence of a similar connection with the treatment CT

The aim was to study the functional state of the kidneys with overweight and obesity. It was established that the average parameters of the GFR of the examined changed along with the growth of the BMI for all types of GFR. If, when calculating according to the MDRD and CKD-EPI formulas, significant differences between the groups were obtained, then, when calculating using the Cockcroft Gault formula, no significant differences were observed. Calculations of GFR using MDRD and CKD-EPI formulas revealed 1.5 times more patients requiring special nephrological examination, treatment correction, and dynamic observation. The calculation of GFR using the MDRD and CKD-EPI formulas is preferable to the calculation using the Cockcroft-Gault metod.

Using of express method of thick drop the proportion of the normal and pathological forms of erythro-cytes were studied. It was shown that in arterial hypertension the part of pathological forms of erythrocytes increases and the part of normal erythrocytes decreases. It is more obviously in second and third degrees of the arterial hypertension

Among the observed patients, the predominant route of HIV infection was injection. The Epstein – Barr virus, Toxoplasma and Mycobacterium tuberculosis were the most frequent pathogens affecting the CNS in HIV-positive patients. The disease developed mainly in young people, regardless of gender. Infectious lesions of the CNS in HIV-positive patients develop gradually and manifest themselves clinically against the back-ground of deep immunodeficiency

The medicinal therapy for urolithiasis should be long-term. The significant side effects of synthetic drugs often requires discontinuation of treatment. Therefore, of the preference is given to herbal medicines. The diu-retic and saluretic abilities of infusions from 15 medicinal plants of the flora of Uzbekistan were studied during treatment of 449 pts with calcium urolithiasis. Infusions has different diuretic power, as well as effects on urine pH and saluresis. The revealed properties of the preparations made it possible to develop criteria for their ad-ministration taking into account the state of diuresis, urine pH, balance of promoters and calcium stone for-mation inhibitors. The selective treatment contributes provide the high therapeutic efficacy and economic bene-fits.

In patients with Parkinson’s disease, anxiety disorders investigated at early and late stages. For this, we used the following scales: To measure the severity of the movement the XEN-YARA scale, to check the final stage of motion defection “UPDRS” (Unified Parkinson`s Disease Rating Scale).As a result, in patients with Parkinson’s disease, anemia and movement disorders develop more often in the late stage of illness than in the earthy stage of the disease

Gastroduodenal bleeding complicates the course of the burn disease and in some cases may increase the
likelihood of death in patients with severe thermal trauma. The analysis of 105 victims with severe thermal
trauma (the area of deep burn 20-40%), who were on treatment from 2010 to 2017, in whom the course of the
burn disease was complicated by the development of gastroduodenal bleeding. Studies have shown that the
pathogenetically substantiated method of choice for the development of massive bleeding in burned patients is
endoscopic arrest on the background of complex haemostatic, replacement and angioprotective therapy

The article analyzes the results of treatment of 34 patients with deep thermal lesions of the upper and lower extremities, aged 15 to 65 years. Among the observed patients with deep burns limb amputations were
performed in 28 patients on 32 extremities. The indications, the technique of operations, the introduction of the
postoperative period, which allows to significantly improve the results of treatment, maximally preserve the
function of the affected limbs, will increase the healing possibilities of combobustology for saving the life of
doomed patients with uncompensated loss of skin

While the problem of arterial hypertension in recent years has become one of the most important in med-icine, and in particular in obstetrics, the issues of pathogenesis, clinical manifestations, complications of preg-nancy and childbirth, possible adverse effects on the fetus, as well as the treatment of arterial hypotension, at-tract significantly less attention of clinicians.

The object of the study were 120 children from 3 to 18 years old, patients with chronic viral hepatitis. General clinical, biochemical, specific laboratory, instrumental, radiation: complex echographic studies, MSCT, MRI, SI of the liver, spleen, biliary tract were used, histological criteria of liver damage, as well as sta-tistical research methods were studied. The use of a set of methods of instrumental methods, along with clinical laboratory and, according to indications, histological studies in chronic viral hepatitis in children, makes it possible to formulate a definitive and reliable diagnosis in the early stages of the disease and carry out ade-quate therapy, prevent complications and transition to a more severe degree of activity or cirrhosis the liver

The defeat of the kidney as the target organ of hypertensive disease in 40% of patients begins to form early - within 5 years from the debut of the disease. The early stage of hypertensive nephropathy is a dynamic process that has clinical and functional markers at each stage, so microalbuminuria, increased intrarenal vas-cular resistance, and changes in the total filtration function of the kidneys are the earliest

Based on the results obtained, patients with peptic ulcer disease should be referred to the risk group for the development of anxiety-depressive disorders, which it is advisable to consult a psychoneurologist during treatment. With comorbidity of peptic ulcer and anxiety-depressive disorders, in addition to eradication thera-py, psychopharmacological therapy is appropriate for patients

In order to avoid undeveloped pregnancy, and intrauterine fetal death, as well as early detection of fetal malformations, there is a need for screening in the first trimester of pregnancy. Inclusion of the first trimester in the screening program in a timely manner will create risk groups for the birth of children with malfor-mations of the fetus, timely resolve the issue of further introduction of pregnancy, thereby reducing obstetric complications, and also reduce maternal and infant mortality

The article considers the state of epileptic seizures and diagnostic indices of patients with epilepsy of ob-servation in 25 patients. The frequency of development of the disease was determined by various epileptic sei-zures. It was also based on the results of an EEG study of patients with a very important diagnosis of epilepsy. Most often, clinical manifestations of attacks were absans and focal motor attacks. The article describes the main pathological changes in the bioelectrical activity of the brain

The analysis of the frequency of fresh injuries and the formation of cicatricial strictures of the main bile ducts in gallstone surgery is given. The probability of damage to the bile duct in surgery for gallstone disease was 0.38%, the incidence of post-traumatic cicatricial stricture - 0.37%. A significant difference in the fre-quency of these complications was determined depending on the type of operations and inflammation in the gallbladder, as well as on the urgency of the operation

Today, the diagnosis of polycystic ovary syndrome is based on the provisions of the Rotterdam Conven-tion (2003) and includes, above all, the diagnosis of hyperandrogenism and oligo / anovulation, which do not allow for the implementation of reproductive function. Other manifestations of PCOS associated with insulin
resistance and dyslipidemia continue to be widely discussed in the literature. And since the frequency of infer-tility in women with hyperandrogenism and anovulation reaches 90%, the issues of treatment of such patients are highly relevant and require a comprehensive solution. This article focuses on the treatment of anovulation through the introduction of ovulation inducers. Research in the field of reproductive gynecology was the basis for the synthesis and clinical use of drugs that stimulate ovulation, and thus, make it possible to realize the gen-ital function

Work is based on the analysis of a condition of inhibitor of metalproteinase-1 at 185 patients with various formations of skin. From them bazalnokletochny cancer of skin has been revealed at 39 patients, planocellular cancer of skin – at 39 people, good-quality education is skin (fibroma) – at 48 patients (group of comparison 1). In addition, researches at the 34th rather healthy the donor volunteer have been conducted (group of comparison 2). Most of patients were male and 50 years are more senior. The greatest number of educations – 25% has been noted on the lower extremities. Concerning educations on a face have asked for medical care of 15% of patients. It should be noted that at the vast majority of patients of this group malignancies have been revealed. As a result of the conducted research it has been established that in pathogenesis of development of any tumoral process of skin increase in TIMP-1 lies. Expeditious treatment at fibroma of skin leads to decrease in TIMP-1, since third postoperative day. Performance of surgical treatment at basal and cellular cancer of skin leads to partial decrease in TIMP-1 since fifth postoperative days. At planocellular cancer of skin occurs, increase in TIMP-1 since first postoperative days, decrease by tenth postoperative days. At the same time performance of expeditious treatment doesn't lead to decrease in TIMP-1 in the remote postoperative period.

The article highlights the actual problem of diagnostics and treatment of cardiogenic shock. A number of measures of a therapeutic and diagnostic nature are given

Complex examination and treatment of 158 patients with staghorn and multiple kidney stones was car-ried out. The use of endoscopic treatment algorithm in patients with staghorn and multiple nephrolithiasis al-lowed to increase the stone free rate up to 90.0%. Inclusion of developed algorithm of endoscopic treatment of patients with staghorn and multiple kidney stones in the complex of therapeutic measures allows to increase the effectiveness of treatment of patients with nephrolithiasis

Among them were 38 women (46.3%) and 44 men (53.7%). The age of patients was 60 to 75 years, the duration of arterial hypertension (AH) was 10 to 23 years. Preoperative preparation of patients with concomi-tant GB, as well as subsequent hemodynamic monitoring is described. The results of the study suggest that ad-equate antihypertensive therapy in combination with sedation and neuroleptanalgesia in the wards of waiting allows achieving stabilization of the clinical state of patients, clearly correlating with improvement of hemody-namic parameters

An assessment of the effectiveness of surgical treatment of 175 patients with fresh injuries of the main bile ducts obtained during various cholecystectomy methods revealed intraoperatively (51) and in the early postoperative period (124) is presented. The proposed algorithms for selecting the method of surgical treat-ment of patients with fresh injuries of the main bile ducts allowed to reduce the overall frequency of postopera-tive complications in the early and late periods from 56.3% to 23.6% and mortality from 10.7% to 4.2%.

The presented article is devoted to the actual problem, that is surgical treatment of esophageal cancer as well as discussion of the modern classification of this pathology, the evaluation of role and perspectives of the newest technologies in esophageal cancer treatment. The analysis of indications, volume of surgical proce-dures and minimally invasive manipulations according to the location and extent of the process in the treatment of esophageal cancer were conducted.

The goal was to study the main symptoms of urogenital candidiasis depending on gender, place of resi-dence of patients. Installed that the main causes of urogenital candidiasis were endocrinopathy, long-term an-tibiotics and cytotoxic drugs, hypovitaminosis. Specific clinical symptoms of urogenital candidiasis are most often detected in women than in men, without reference to age and place of residence

During the study of peculiarities of lipid metabolism in mother- placenta-fetus system at hypotrophy it
was determined that at growth retaliation of intrauterine fetus development the considerable changes take place, especially in NTFA (non terrified fatty acids), triglycerides,3-lipoproteides and phospholipids. By that
the one directed character of changes in blood serum of the pregnant and their newborns, were determined at
retardation of intrauterine fetus development there was value reduction of NTFA-triglycerides, reflecting the
activity of lipolitic processes, being displayed with hyperlipidemia.

This paper presents the characteristics of comorbidity with anorectal malformations in girls. The study included 210 patients aged from 1 day to 15 years, with different forms of ARМwas observed in the clinic of hospital pediatric surgery TashPMI in 2004 - 2017. At 116 - 55.2% of patients identified Associated anomalies of other organs.

32 patients with chronic heart failure of II B and III stage underwent intravenous drip of isosorbide dini-
tratis (isoket) on a conventional method. All patients were recorded external respiration rates before and after
infusion Intravenous injection of the isoket within 10-15 minutes led to an improvement in the clinical condition
of the patients. This was manifested by a decrease in dyspnea, cyanosis, swelling of the cervical veins, etc. Un-
der the influence of infusion, pulmonary volumes significantly increased - vital and forced vital capacity of the
lungs. With a significantly reduced dyspnea, the minute volume of respiration decreased reliably, the volume of
forced expiration in the first second increased gradually. The parameters of maximum ventilation and the Ty-
phon index were not significantly changed.

The article provides operational methods for treating patients with splinter fractured fractures of the dis-tal end of the humerus in 79 patients. Patients were divided into three groups, depending on the method of sur-gical treatment. The results of treatment of operative methods of all three groups are studied and the conclu-sion is made. As a result of the proposed method of treatment of authors, the effectiveness of treatment with reconstructive plates was proved

Multiple organ failure complicates the course of the burn disease and increases the likelihood of death in patients with severe thermal trauma. The analysis of 210 victims (mean age 25.5±5.4 years) with deep burns of more than 25% of the body surface and a burn shock of I-II-III degree (deep burn area of 20-40% bw) from 2010 to 2017 years. The structure of polyorganic insufficiency, frequency (cardiovascular, respiratory, renal, hepatic insufficiency, dysfunction of the central nervous system, gastrointestinal tract) and methods of its cor-rection are studied.